Trade facilitation in Asia and the Pacific is entering a new phase of digital transformation driven by artificial intelligence (AI) and machine learning (ML). Building on earlier advances such as electronic data interchange, single window systems, and cross-border paperless trade, AI is enabling more adaptive, data-driven approaches to managing trade processes. Recent developments in Generative AI (GenAI) have further expanded opportunities to automate document-intensive tasks and improve decision-making across trade value chains. Using the Buy–Ship–Pay framework, this report examines how AI is being applied across commercial, border, and financial processes. AI supports trade documentation, compliance preparation, risk assessment, document verification, nonintrusive inspection, and trade finance operations. Evidence from case studies shows that AI can improve efficiency, accuracy, and compliance while strengthening risk management. However, successful deployment depends on high-quality data, human oversight, and integration across agencies and digital systems. Findings from the ESCAP–ADB Survey on Artificial Intelligence in Trade Facilitation show that AI adoption remains at an early stage, with utilization below 15% across the region and significant variation across subregions. The survey also reveals a gap between data readiness and actual AI deployment, suggesting that many economies have yet to translate digital foundations into operational AI applications. The most significant barriers to adoption are shortages of AI-related skills and high infrastructure costs, followed by institutional fragmentation, data challenges, and regulatory uncertainty. To address these constraints, the report proposes three mutually reinforcing priorities: strengthening human capacity and institutional readiness, building integrated data and digital infrastructure, and enhancing governance and regulatory frameworks. Together, these measures can help economies scale AI-enabled trade facilitation and realize its potential to support more efficient, resilient, and inclusive trade.