Is Hantavirus Deadly? — Fatality Rate
- Hantavirus Pulmonary Syndrome (HPS) has a mortality rate of about up to 50%.
- Hemorrhagic Fever with Renal Syndrome (HFRS) has a mortality rate ranging from 1% to 15% depending on the specific virus strain.
Real-time hantavirus case map aggregating data from WHO, CDC, PAHO and Argentina BEN. Tracking the MV Hondius cruise ship cluster and global endemic surveillance.
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3 deceased · 8 confirmed · 12 Andes cases YTD · Argentine Patagonia · 194 news signals · Click any marker for source details
Hantaviruses are a family of viruses spread mainly by rodents and can cause diverse disease syndromes in people worldwide. Infections with any hantavirus can produce hantavirus disease in people.
The current risk of hantavirus to the general public is extremely low. The MV Hondius cluster is geographically contained. No cases have been reported in the US as a result of this outbreak.
Hantavirus vs Flu — early stage comparison
| Hantavirus | Flu |
|---|---|
| Fatigue | Fatigue |
| Fever | Fever |
| Muscle aches | Muscle aches |
| Shortness of breath | Cough / sore throat |
| No runny nose | Runny nose common |
Seek medical care immediately if you have been in contact with an infected person and develop fever or breathing difficulty.
Hantaviruses are a family of viruses spread mainly by rodents and can cause diverse disease syndromes in people worldwide. Infections with any hantavirus can produce hantavirus disease in people.
Hantaviruses are a family of viruses spread mainly by rodents and can cause diverse disease syndromes in people worldwide. Infections with any hantavirus can produce hantavirus disease in people.
Hantavirus is transmitted through inhalation of aerosolized particles from infected rodent urine, droppings, or saliva — not through casual airborne contact between people. The virus becomes airborne when dried rodent excreta is disturbed, such as during cleaning. It is not spread through coughing or sneezing between humans.
Most hantavirus strains, including Sin Nombre virus (North America), do not spread between people. Andes virus is the documented exception: close contact with an infected person can result in transmission, as seen in the MV Hondius 2026 cluster. Standard infection-control precautions (masks, hand hygiene, isolation) are recommended for confirmed cases.
Hantavirus is found worldwide. In the Americas, Sin Nombre virus is prevalent across the western United States, while Andes virus is endemic to Patagonia (Argentina and Chile). In Europe and Asia, Seoul and Puumala viruses circulate broadly. Cases are most common in rural areas with high rodent populations.
Hantavirus Pulmonary Syndrome (HPS), caused by strains like Sin Nombre and Andes virus, has a case-fatality rate of 20–40%, and can reach up to 50%. Hemorrhagic Fever with Renal Syndrome (HFRS), caused by strains like Seoul and Hantaan virus, has a lower fatality rate of 1–15% in Asia and Europe, depending on the specific strain.
There is no FDA-approved vaccine for hantavirus in the United States or most Western countries. Some vaccines have been developed and used in China and South Korea for HFRS strains. Research into broader hantavirus vaccines is ongoing. Prevention currently relies on rodent control and avoiding exposure to rodent excreta.
In late April 2026, a cluster of Andes virus (hantavirus) cases was identified among passengers and crew of the MV Hondius, a cruise ship operating in the South Atlantic near Patagonia. The outbreak is significant because Andes virus is the only hantavirus known to spread person-to-person. WHO has issued multiple Disease Outbreak News reports tracking the cluster.
Unlike COVID-19, hantavirus is not a human respiratory virus that spreads through the air between people. It requires direct contact with or inhalation of aerosolized rodent excreta. Hantavirus does not cause large-scale human-to-human transmission chains (with the rare exception of Andes virus), so its outbreak potential is generally localized rather than pandemic.
For most people, the risk of hantavirus infection remains low. The MV Hondius cluster is a notable event due to Andes virus's rare person-to-person transmission, but it is geographically contained. The greatest risk is for people in rural areas with rodent exposure. Follow standard prevention: avoid contact with rodents, seal entry points in buildings, and use proper protective equipment when cleaning potentially contaminated areas.