Conflict in the pangenome
PFLU4242-pQBR plasmid interactions - an exemplary model of pangenome conflict
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Key reference: Plasmid fitness costs are caused by specific genetic conflicts enabling resolution by compensatory mutation (Hall et al, 2021)
Key reference: Plasmid fitness costs are caused by specific genetic conflicts enabling resolution by compensatory mutation (Hall et al, 2021)
Plasmids play an important role in bacterial genome evolution by transferring genes between lineages. Fitness costs associated with plasmid carriage are expected to be a barrier to gene exchange, but the causes of plasmid fitness costs are poorly understood. Single compensatory mutations are often s …
Key reference: Extremely fast amelioration of plasmid fitness costs by multiple functionally diverse pathways (Hall et al, 2020)
Key reference: Extremely fast amelioration of plasmid fitness costs by multiple functionally diverse pathways (Hall et al, 2020)
The acquisition of plasmids is often accompanied by fitness costs such that compensatory evolution is required to allow plasmid survival, but it is unclear whether compensatory evolution can be extensive or rapid enough to maintain plasmids when they are very costly. The mercury-resistance plasmid p …
Reference: clinker & clustermap.js: Automatic generation of gene cluster comparison figures (Gilchrist, C.L.M., Chooi, Y.-H., 2020)
Reference: clinker & clustermap.js: Automatic generation of gene cluster comparison figures (Gilchrist, C.L.M., Chooi, Y.-H., 2020)
Reference: Phylogenomics and sequence-structure-function relationships in the GmrSD family of Type IV restriction enzymes (Machnicka et al, 2015)
Reference: Phylogenomics and sequence-structure-function relationships in the GmrSD family of Type IV restriction enzymes (Machnicka et al, 2015)
Reference: PRANK (Löytynoja Lab, University of Helsinki)
Reference: PRANK (Löytynoja Lab, University of Helsinki)
Reference: raxmlGUI 2.0: A graphical interface and toolkit for phylogenetic analyses using RAxML (Edler et al, 2020)
Reference: raxmlGUI 2.0: A graphical interface and toolkit for phylogenetic analyses using RAxML (Edler et al, 2020)
PFLU4242 brought to life by artist Annelisë Pilkington
PFLU4242 brought to life by artist Annelisë Pilkington
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