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Baran Lab Papers
Baran Lab Papers
First Author: Pyrolytic Carbon
First Author: Pyrolytic Carbon
Synthetic organic electrochemistry is recognized as one of the most sustainable forms of redox chemistry that can enable a wide variety of useful transformations. In this study, readily prepared pyrolytic carbon electrodes are explored in several powerful ...
EChem & Flow Resources
EChem Flow Reactor Overview
EChem Flow Reactor Overview
A Survival Guide for the “Electro-curious”
A Survival Guide for the “Electro-curious”
Electroorganic Chemistry: Choice of Electrodes
Electroorganic Chemistry: Choice of Electrodes
Flow Essentials
Flow Essentials
Echem or Photochem? How to decide
Echem or Photochem? How to decide
Involved Projects
Proteomic Ligandability Maps of Phosphorus(V) Stereoprobes Identify Covalent TLCD1 Inhibitors
Proteomic Ligandability Maps of Phosphorus(V) Stereoprobes Identify Covalent TLCD1 Inhibitors
Simple, Enantiocontrolled Azetidine Library Synthesis via Strain Release Functionalization of 1-AzaBCBs
Simple, Enantiocontrolled Azetidine Library Synthesis via Strain Release Functionalization of 1-AzaBCBs
Simplifying Access to Targeted Protein Degraders via Ni-Electrocatalytic Cross-Coupling
Simplifying Access to Targeted Protein Degraders via Ni-Electrocatalytic Cross-Coupling
C–C linked glutarimide-containing structures with direct utility in the preparation of cereblon-based degraders (PROTACs, CELMoDs) can be assessed in a single step from inexpensive, commercial -bromoglutaramide through a unique Brønsted-acid assisted Ni-...
Ni-Electrocatalytic Decarboxylative Arylation to Access Quaternary Centers
Ni-Electrocatalytic Decarboxylative Arylation to Access Quaternary Centers
Overcoming Limitations in Decarboxylative Arylation via Ag–Ni Electrocatalysis
Overcoming Limitations in Decarboxylative Arylation via Ag–Ni Electrocatalysis
A useful protocol for achieving decarboxylative cross-coupling (DCC) of redox-active esters (RAE, isolated or generated in situ) and halo(hetero)arenes is reported. This pragmatically focused study employs a unique Ag–Ni electrocatalytic platform to overcome numerous limitations that have plagued this strategically powerful transformation. In its optimized form, coupling partners can be combined in a surprisingly simple way: open to the air, using technical-grade solvents, an inexpensive ligand and Ni source, and substoichiometric AgNO3, proceeding at room temperature with a simple commercial potentiostat. Most importantly, all of the results are placed into context by benchmarking with state-of-the-art methods. Applications are presented that simplify synthesis and rapidly enable access to challenging chemical space. Finally, adaptation to multiple scale regimes, ranging from parallel milligram-based synthesis to decagram recirculating flow is presented.
Decarboxylative Cross-Coupling: A Radical Tool in Medicinal Chemistry
Decarboxylative Cross-Coupling: A Radical Tool in Medicinal Chemistry
Carboxylic acids, the most versatile and ubiquitous diversity input used in medicinal chemistry for canonical polar bond constructions such as amide synthesis, can now be employed in a fundamentally different category of reaction to make C–C bonds by harnessing the power of radicals. This outlook serves as a user-guide to aid practitioners in both the design of syntheses that leverage the simplifying power of this disconnection and the precise tactics that can be employed to enable them. Taken together, this emerging area holds the potential to rapidly accelerate access to chemical space of value to modern medicinal chemistry.
Scalable, Chemoselective Nickel Electrocatalytic Sulfinylation of Aryl Halides with SO2
Scalable, Chemoselective Nickel Electrocatalytic Sulfinylation of Aryl Halides with SO2
Electroreductive Synthesis of Nickel(0) Complexes
Electroreductive Synthesis of Nickel(0) Complexes
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