Eduard Porta
Junior Group Leader, working on spatial biology, cancer genomics and AI
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Spatial papers and preprints
Spatial biomarkers of response to neoadjuvant therapy in muscle-invasive bladder cancer: the DUTRENEO trial
Spatial biomarkers of response to neoadjuvant therapy in muscle-invasive bladder cancer: the DUTRENEO trial
medRxiv - the preprint server for biology, operated by openRxiv, a nonprofit organization dedicated to advancing scientific communication
The spatial landscape of cancer hallmarks reveals patterns of tumor ecological dynamics and drug sensitivity
The spatial landscape of cancer hallmarks reveals patterns of tumor ecological dynamics and drug sensitivity
A Practical Guide to Spatial Transcriptomics: Lessons from over 1000 Samples
A Practical Guide to Spatial Transcriptomics: Lessons from over 1000 Samples
Benchmarking of spatial transcriptomics platforms across six cancer types
Benchmarking of spatial transcriptomics platforms across six cancer types
CPTAC and TCGA
Precision proteogenomics reveals pan-cancer impact of germline variants
Precision proteogenomics reveals pan-cancer impact of germline variants
Comprehensive Characterization of Cancer Driver Genes and Mutations
Comprehensive Characterization of Cancer Driver Genes and Mutations
Pan-cancer proteogenomics connects oncogenic drivers to functional states
Pan-cancer proteogenomics connects oncogenic drivers to functional states
A multi-omics analysis-based resource across ten cancer types from more than 1,000 patients provides pan-cancer insights into shared oncogenic driver mechanisms and pathways.
The Immune Landscape of Cancer
The Immune Landscape of Cancer
Thorsson et al. present immunogenomics analyses of more than 10,000 tumors, identifying six immune subtypes that encompass multiple cancer types and are hypothesized to define immune response patterns impacting prognosis. This work provides a resource for understanding tumor-immune interactions, with implications for identifying ways to advance research on immunotherapy.
Perspective on Oncogenic Processes at the End of the Beginning of Cancer Genomics
Perspective on Oncogenic Processes at the End of the Beginning of Cancer Genomics
A synthesized view on oncogenic processes based on PanCancer Atlas analyses highlights the complex impact of genome alterations on the signaling and multi-omic profiles of human cancers as well as their influence on tumor microenvironment.
Integrative multi-omic cancer profiling reveals DNA methylation patterns associated with therapeutic vulnerability and cell-of-origin
Integrative multi-omic cancer profiling reveals DNA methylation patterns associated with therapeutic vulnerability and cell-of-origin
Liang et al. catalog pan-cancer DNA methylation with concordant transcriptional and translational changes, revealing lineage-specific epigenetic driver FGFR2 hypomethylation in uterine corpus endometrial carcinoma, and STAT5 hypermethylation as an immunosuppression switch in squamous tumors. They also identify methylation-driven subtypes associated with cell-of-origin, tumor heterogeneity, tumor phenotype, and links to therapeutic potential.
Multi-scale signaling and tumor evolution in high-grade gliomas
Multi-scale signaling and tumor evolution in high-grade gliomas
Liu et al. integrate 14 proteogenomic, glycoproteomic, and metabolomic platforms on 228 high-grade gliomas composed of glioblastomas and grade 4 IDH-mutant astrocytomas, including tumors at recurrence. This study identifies multi-scale regulatory interactions governing tumor development and evolution, reveals heterogeneous upstream alterations converging on common downstream events, and suggests a central role for PTPN11 signaling across high-grade gliomas.
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