Is there an advantage to creating a database in python vs. Excel?

I apologize if this is a stupid question.

If I want to make a database of patient information and various factors, are there any advantages to doing this in python instead of in excel and then exporting the data to python?

Can I use python to easily make a data entry tool?

Are there GUIs that allow for easily importing data from .xslx like with Rstudio in R?