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Overheard on Reddit, u/Itsyademonboi:
Sorry, Nazis are from Germany under Adolf Hitler, what we have here is Sparkling Fascists.
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For those of you in the parts of the US for whom an ice storm is predicted and who have no idea of what that is except that it means it will be cold:

1) If you have an ice scraper to clean the ice off your car, have it inside with you, not in the car. Because at a sufficient level of ice coating, leaving your ice scraper in the car is like leaving your car keys in the car.

1a) Honestly, at a certain level of ice coating, it's more like having one's car coated in concrete, and you shouldn't waste your energy and body warmth whaling futilely at it. One of the failure modes is you succeed in getting the ice off but take the windshield with it.

2) You probably associate winter storms and coldness with grey-overcast skies and darkness. But once it is done coming down, often the arctic winds that drove the storm will blow the clouds away, the skies clear and the sun will come up. I cannot begin to describe how bright it gets when the sun is shining and the whole world is made of glass. If you packed your sunglasses away for the winter, go get them out. If you store them in your glove compartment of your car, again, maybe go get them and have them inside with you so you can see what you're doing when you are trying to get the ice off the car.

3) All that said, maybe just don't be worrying about leaving home. A fundamental clue is that an ice storm is not done when the storm is done raging. For as long as there's a thick glaze of ice on everything, the crisis is not over. Your life experience has given you an intuition of physics that says ice forms where water pools and is therefore mostly something flat. But in an ice storm, you get ice coating absolutely everything including sloped and vertical surfaces. YouTube is willing to show you endless videos of people attempting and failing to walk up quite gentle slopes covered with ice and cars slowly and majestically sliding down hills. Driving and walking can be unbelievably dangerous after an ice storm. Try to ride it out by sheltering in place and don't try to go out in it if you can at all avoid it. Remember, it's not about how good a driver you are, it's about how good a driver everybody else on the road isn't.

4) Snow and ice falling off buildings can kill you. Yes, I know snow looks fluffy, but it is made of water and can compact to be quite solid and if it attains free fall it can build up quite a bit of momentum. Icicles are basically spears. If you endeavor to try to knock snow or ice off from a roof or other high structure, be real careful how you position yourself relative to it.

5) Now and until this is over is absolutely not the time to do anything that entails any unnecessary risk. Any activity that is at all discretionary that has even a remote likelihood of occasioning an ER trip is to be avoided. Boredom, I know, makes people find their own fun. Resist the urge.
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Hey, Americans! Do you live around or south of the Mason-Dixon line? If so, your weather report for later this week is shaping up to be a bit exciting. Looks like Actual Winter will be visiting places that historically have been poorly prepared for this sort of thing, i.e. TX, the South, and the mid-Atlantic.

(Also eventually the NE, but a forecast of a few feet of snow is threatening us with a good time.)

H/t to the RyanHallYall YT channel. He's a well-reputed amateur, but his report is congruent with what I'm seeing in conventional weather reports:


https://youtube.com/shorts/nh4JEVGWfFU

Good luck and remember running a charcoal grill in your living room is a dumb way to die.
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I found this intriguing. YouTuber KnittingCultLady, who is an Air Force veteran and author about two books on military culture from the standpoint of cults(!), put out this rather frustrated video clarifying how members of the military respond to illegal orders. The tl;dr is they will follow orders of ambiguous legality, and refuse to follow orders of obvious illegality, and what is obviously illegal may not be what civilians think.

2026 Jan 18: KnittingCultLady on YT: Some Examples of Recent Malicious Compliance from the Military, ALSO Listen Carefully To My Words:


She doesn't put it this way, but it sounds from what she says that what makes something obviously illegal is that it resulted in a courtmartial or other nigh-universal condemnation when tried previously. Orders that are for doing things that are war crimes by the letter of the law but which did not result in prosecution or other negative consequences for the perpetrators when done in the past do not trigger the sense that they are illegal, e.g. if it was okay for Bush to seize Noriega, then clearly it must be legal for Trump to seize Maduro.
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(h/t [personal profile] hudebnik)

Two things: this is a thing that has happened, I have a read on what it is that nobody else seems to have come up with.

1) The thing that happened:

2026 Jan 16: NYTimes: "Thousands of Chinese Fishing Boats Quietly Form Vast Sea Barriers" by Chris Buckley, Agnes Chang and Amy Chang Chien

The most interesting thing here is the visualization animations, so if that link doesn't work for you:

2026 Jan 17: TaiwanPlus News [TaiwanPlusNews on YT]: "NYT: China Tests Civilian Fishing Boats in Maritime Military Operations"


2) Take:

“The sight of that many vessels operating in concert is staggering,” said Mark Douglas, an analyst at Starboard, a company with offices in New Zealand and the United States. Mr. Douglas said that he and his colleagues had “never seen a formation of this size and discipline before.”

“The level of coordination to get that many vessels into a formation like this is significant,” he said.
Yeah, so, about that:



It turns out that the world leader in developing systems for coordinating large numbers of semi-autonomous vehicles is China.

The way a drone show works is that the design of the show and the intended positions and trajectories of all the individual drones is calculated and stored on the coordinating computer, from which they are transmitted to the drones during the show. However, drones in the air can be knocked off course by turbulence, so they also have onboard collision avoidance and position resumption algorithms.

The drone show company in question, Shenzhen DAMODA Intelligent Control Technology Co., Ltd. brags they can control 10,000 drones from a single laptop.

There were only 2,000 ships. Well within what their system could handle.

So what this could be is a test of such a coordination technology deployed to civilian boats.

Perhaps on each of those ships was either a sail-by-wire system that puts them under remote/autonomous control, or a receiver/interface that relayed instructions to the human pilots from a drone-controller that both received orders from command-and-control and managed the specifics of positioning through the same sort of collision-avoidance and repositioning algorithm as light-show drones.

Also, I suspect the way DAMODA manages to control so many devices from a single laptop – I was not able to quickly get a bead on this, and it would be unsurprising if they were less than forthcoming about their secret sauce – is that they have been figuring out ways to offload more and more of the steering logic onto the drones themselves. There comes a point, I suppose, where the logic for collision avoidance and repositioning crosses over into what used to be called (back in the 1980s and 1990s) flocking algorithms. Perhaps this was a test of a flocking algorithm based system for boats.

In any event, this might not be an example of a lot of people doing a thing. This might be an example of a thing being done to a lot of people. I mean, it almost certainly is the latter in that the government of China's modus operandi is to "voluntell" its citizens, and one of the concerning things here is the apparent use of civilians for military maneuvers. I'm saying this might be a test of a system that doesn't rely on acquiescence to government authority.
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This was it. This was the week that America admitted America is going fascist – which is to say has gone fascist, i.e. has had its government seized by fascists with broad fascist support for imposing fascism which it is now doing with zeal, i.e. has an acute case of fulminant fascism.

I've been watching this bear down on us for a half a century, so it's slightly dizzying to finally have everybody else come into alignment. One of the basic exigencies of my life has been moving through the world being reasonably certain of a bunch of things that I knew the vast majority of my fellows thought were insane to believe. Over the last ten years, more and more people have been noticing, "what are we doing in this handbasket and where is it going?" but – as evidenced by the behavior of the DNC over the last year – it's taken the secret police gunning Americans down in the streets (since I started writing this: and throwing flashbang grenades at or into (reports vary) passing cars carrying little kids) for the greater liberal mass to come around.

Obviously, it would have been nicer for the realization It Could Happen Here to have not required It Happening Here to be the conclusive rebuttal of their pathological skepticism. But one of my favorite sayings is, "There's three kinds. The one that learns by reading. The few who learn by observation. The rest of them have to pee on the electric fence for themselves," (Will Rogers) and this is why. Clearly America needed to piss on the electric fence for itself. I try to be philosophical about it.

I just felt, if only for myself and posterity, I should note this long-in-coming nation-wide realization has finally been attained.

I'm not getting too carried away, though. It's hard to be too jubilant when the problem that brought us here is still very much with us, by which I don't mean the fascism itself, I mean the terrible mentality on "my" "side" that causes that pathological skepticism and other catastrophic thinking faults that brought us to this pass and lead to the fascists getting away, quite literally, with murder.
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This is blackly hilarious and absolutely worth a read.

Leftist journalist Laura Jedeed showed up at an ICE recruiting events to do scope it out and write about what she found. What happened next is... eye widening.

2026 Jan 13: Slate: "You’ve Heard About Who ICE Is Recruiting. The Truth Is Far Worse. I’m the Proof." [Paywall defeater] by Laura Jedeed:
At first glance, my résumé has enough to tantalize a recruiter for America’s Gestapo-in-waiting: I enlisted in the Army straight out of high school and deployed to Afghanistan twice with the 82nd Airborne Division. After I got out, I spent a few years doing civilian analyst work. With a carefully arranged, skills-based résumé—one which omitted my current occupation—I figured I could maybe get through an initial interview.

The catch, however, is that there’s only one “Laura Jedeed” with an internet presence, and it takes about five seconds of Googling to figure out how I feel about ICE, the Trump administration, and the country’s general right-wing project. My social media pops up immediately, usually with a preview of my latest posts condemning Trump’s unconstitutional, authoritarian power grab. Scroll down and you’ll find articles with titles like “What I Saw in LA Wasn’t an Insurrection; It Was a Police Riot” and “Inside Mike Johnson’s Ties to a Far-Right Movement to Gut the Constitution.” Keep going for long enough and you might even find my dossier on AntifaWatch, a right-wing website that lists alleged members of the supposed domestic terror organization. I am, to put it mildly, a less-than-ideal recruit.

In short, I figured—at least back then—that my military background would be enough to get me in the door for a good look around ICE’s application process, and then even the most cursory background check would get me shown that same door with great haste.

[...]

I completely missed the email when it came. I’d kept an eye on my inbox for the next few days, but I’d grown lax when nothing came through. But then, on Sept. 3, it popped up.

“Please note that this is a TENTATIVE offer only, therefore do not end your current employment,” the email instructed me. It then listed a series of steps I’d need to quickly take. I had 48 hours to log onto USAJobs and fill out my Declaration for Federal Employment, then five additional days to return the forms attached to the email. Among these forms: driver’s license information, an affidavit that I’ve never received a domestic violence conviction, and consent for a background check. And it said: “If you are declining the position, it is not necessary to complete the action items listed below.”

As I mentioned, I’d missed the email, so I did exactly none of these things.

And that might have been where this all ended—an unread message sinking to the bottom of my inbox—if not for an email LabCorp sent three weeks later. “Thank you for confirming that you wish to continue with the hiring process,” it read. (To be clear, I had confirmed no such thing.) “Please complete your required pre-employment drug test.”

The timing was unfortunate. Cannabis is legal in the state of New York, and I had partaken six days before my scheduled test. Then again, I hadn’t smoked much; perhaps with hydration I could get to the next stage. Worst-case scenario, I’d waste a small piece of ICE’s gargantuan budget. I traveled to my local LabCorp, peed in a cup, and waited for a call telling me I’d failed.

Nine days later, impatience got the best of me. For the first time, I logged into USAJobs and checked my application to see if my drug test had come through. What I actually saw was so implausible, so impossible, that at first I did not understand what I was looking at.

Somehow, despite never submitting any of the paperwork they sent me—not the background check or identification info, not the domestic violence affidavit, none of it—ICE had apparently offered me a job.

According to the application portal, my pre-employment activities remained pending. And yet, it also showed that I had accepted a final job offer and that my onboarding status was “EOD”—Entered On Duty, the start of an enlistment period. I moused over the exclamation mark next to “Onboarding” and a helpful pop-up appeared. “Your EOD has occurred. Welcome to ICE!”

I clicked through to my application tracking page. They’d sent my final offer on Sept. 30, it said, and I had allegedly accepted. “Welcome to Ice. … Your duty location is New York, New York. Your EOD was on Tuesday, September 30th, 2025.”

By all appearances, I was a deportation officer. Without a single signature on agency paperwork, ICE had officially hired me.
Click through to read the whole thing.
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2026 Jan 14: NYT: "Renfrew Christie Dies at 76; Sabotaged Racist Regime’s Nuclear Program" by Adam Nossiter. "He played a key role in ending apartheid South Africa’s secret weapons program in the 1980s by helping the African National Congress bomb critical facilities."
Image
Renfrew Christie in 1988.

Renfrew Christie, a South African scholar whose undercover work for the African National Congress was critical in hobbling the apartheid government’s secret nuclear weapons program in the 1980s, died on Dec. 21 at his home in Cape Town. He was 76.

The cause of death was pneumonia, his daughter Camilla Christie said.

President Cyril Ramaphosa of South Africa paid tribute to Dr. Christie after his death, saying his “relentless and fearless commitment to our freedom demands our appreciation.”

The A.N.C., in a statement, called Dr. Christie’s role “in disrupting and exposing the apartheid state’s clandestine nuclear weapons program” an “act of profound revolutionary significance.”

From the doctoral dissertation he had written at the University of Oxford on the history of electricity in South Africa, Dr. Christie provided the research needed to blow up the Koeberg Nuclear Power Station; the Arnot coal-fired power station; the Sasol oil-from-coal facilities that produced the heavy water critical to producing nuclear weapons; and other critical sites.

The explosions set back South Africa’s nascent nuclear weapons program by years and cost the government more than $1 billion, Dr. Christie later estimated.

By the time the bombs began going off, planted by his colleagues in uMkhonto we Sizwe, the paramilitary wing of the A.N.C., Dr. Christie was already in prison. He was arrested by South African authorities in October 1979 on charges of “terrorism,” three months after completing his studies at Oxford, and spent the next seven years in prison, some of that time on death row and in solitary confinement.


“While I was in prison, everything I had ever researched was blown up,” he said in a speech in 2023.

Terrorism was a capital offense, and Dr. Christie narrowly escaped hanging. But as he later recounted, he was deliberately placed on the death row closest to the gallows at the Pretoria Maximum Security Prison. For two and half years, he was forced to listen to the hangings of more than 300 prisoners.

“The whole prison would sing for two or three days before the hanging, to ease the terror of the victims,” Dr. Christie recalled at a 2013 conference at the University of the Western Cape on laws regarding torture.

Then he recited the lyrics of an anti-apartheid folk song that reverberated in the penitentiary: “‘Senzeni-na? Senzeni-na? What have we done? What have we done?’ It was the most beautiful music on earth, sung in a vile place.”



“At zero dark hundred,” he continued, “the hanging party would come through the corridors to the gallows, slamming the gates behind them on the road to death. Once they were at the gallows there was a long pause. Then — crack! — the trapdoors would open, and the neck or necks of the condemned would snap. A bit later came the hammering, presumably of nails into the coffins.”

In an interview years later with the BBC, he said the “gruesome” experience affected him for the rest of his life.

Dr. Christie acquired his fierce antipathy to apartheid at a young age, growing up in an impoverished family in Johannesburg.

Many of his family members fought with the Allied forces against the Germans in World War II, and “I learned from them very early that what one does with Nazis is kill them,” he said at a 2023 conference on antinuclear activism in Johannesburg. “I am not a pacifist.”

At 17, he was drafted into the South African Army. A stint of guard duty at the Lenz ammunition dump south of Johannesburg confirmed his suspicions that the government was building nuclear weapons. “From the age of 17, I was hunting the South African bomb,” he said at the conference.

After attending the University of the Witwatersrand, he received a scholarship to Oxford, which enabled him to further his quest. For his doctoral dissertation, he chose to study South Africa’s history of electrification, “so I could get into the electricity supply commission’s library and archives, and work out how much electricity they were using to enrich uranium,” he told the BBC.

From there, it was possible to calculate how many nuclear bombs could be produced. Six such bombs had reportedly been made by the end of apartheid in the early 1990s; the United States had initially aided the regime’s nuclear program. Thanks to the system of forced labor, South Africa “made the cheapest electricity in the world,” Dr. Christie said, which aided the process of uranium enrichment and made the country’s nuclear program a magnet for Western support. (South Africa also benefited from its status as a Cold War ally against the Soviet Union.)

Dr. Christie turned his findings over to the A.N.C. Instead of opting for the safety of England — there was the possibility of a lecturer position at Oxford — he returned home and was arrested by South Africa’s Security Police. He had been betrayed by Craig Williamson, a fellow student at Witwatersrand, who had become a spy for the security services and was later granted amnesty by South Africa’s Truth and Reconciliation Commission.

After 48 hours of torture, Dr. Christie wrote a forced confession — “the best thing I ever wrote,” he later told the BBC, noting that he had made sure the confession included “all my recommendations to the African National Congress” about the best way to sabotage Koeberg and other facilities.

“And, gloriously, the judge read it out in court,” Dr. Christie added. “So my recommendations went from the judge’s mouth” straight to the A.N.C.

Two years later, in December 1982, Koeberg was bombed by white A.N.C. operatives who had gotten jobs at the facility. They followed Dr. Christie’s instructions to the letter.


“Of all the achievements of the armed struggle, the bombing of Koeberg is there,” Dr. Christie said at the 2023 conference, emphasizing its importance. “Frankly, when I got to hearing of it, it made being in prison much, much easier to tolerate.”

Renfrew Leslie Christie was born in Johannesburg on Sept. 11, 1949, the only child of Frederick Christie, an accountant, and Lindsay (Taylor) Christie, who was soon widowed and raised her son alone while working as a secretary.

He attended King Edward VII School in Johannesburg and was conscripted into the army immediately after graduating. After his discharge, he enrolled at Witwatersrand. He was twice arrested after illegally visiting Black students at the University of the North at Turfloop, and was also arrested during a march on a police station where he said the anti-apartheid activist Winnie Mandela was being tortured.

He didn’t finish the course at Witwatersrand, instead earning bachelor’s and master’s degrees from the University of Cape Town in the mid-1970s before studying at Oxford. At Cape Town, he was a leader of the National Union of South African Students, an important anti-apartheid organization.

On June 6, 1980, he was sentenced to 10 years in prison under South Africa’s Terrorism Act, with four other sentences of five years each to run concurrently.

“I spent seven months in solitary,” Dr. Christie said in the 2023 speech. “Don’t let anybody kid you: No one comes out of solitary sane. My nightmares are awful.”

After his years in prison, he was granted amnesty in 1986 as the apartheid regime began to crumble. (It officially ended in 1994, when Nelson Mandela became the country’s first Black president.) He later had a long academic career at the University of the Western Cape, retiring in 2014 as dean of research and senior professor.

In addition to his daughter Camilla, he is survived by his wife, Dr. Menán du Plessis, a linguist and novelist he married in 1990; and another daughter, Aurora.

Asked by the BBC whether he was glad he had spied for the A.N.C., Dr. Christie didn’t hesitate.

“I was working for Nelson Mandela and uMkonto we Sizwe,” he said. “I’m very proud of that. We won. We got a democracy.”

Kirsten Noyes contributed research.



In prison cell and dungeon vile
Our thoughts to them are winging
When friends by shame are undefiled
How can I keep from singing?

– Pete Seeger
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Heads up, locals! Observers report evidence of ICE/DHS activity preparing for an operation in MA, imminently.

2026 Jan 13 5pm: u/rarelighting in r/Boston: Boston quietly prepares for an ICE surge, points at:

2026 Jan 13: Axios: Boston quietly prepares for an ICE surge by Mike Deehan

Discussion at Reddit:
OP:

While listening to the Sam Seder podcast today, someone sent in a report about increased activity at the Burlington ICE facilities. Stay alert folks.


u/Neat-Beautiful-5505 • 4h ago

Another Reddit post showed three 18-wheel trucks hauling several new SUVs each to the Burlington ICE facility.


u/_still_truckin_ • 4h ago

Two dozen white Ford Explorers. They’re the same Interceptor models that real police departments use. You can spot them by the searchlight mounted to the driver side A-pillar and lack of tracks for roof racks. Saw them in the parking lot of the Burlington ICE building.


u/ThePirateKing01 • 4h ago

Shoutout to @BearingWitnessBurlington on YouTube and TikTok

To those who say protesting peacefully doesn’t amount to much, this person has been both protesting and monitoring the facility almost 24/7. Without people like this we wouldn’t have the heads up that we do now



u/minilip30  • 4h ago

“The bottom line: While no operation has been officially confirmed, Boston is not waiting to find out — it is mobilizing now.”

Good!

Remember, ICE needs a warrant to enter any private residence or business. Business that aren’t fascist supporting should have signs that they will not allow ICE entry without a warrant.


u/beanandcod • 4h ago

A judicial warrant, signed by a judge


u/Pnoman98 • 4h ago

A lot of police presence at Alewife& Gov Center


u/cccxxxzzzddd • 4h ago

The Rindge / fresh pond apartments at alewife are home to many immigrants, particularly Ethiopians

This is not good 

Edit: not good that ice is there


u/mysteriousfrittata • 4h ago

Saw a car full of them parked outside of MGH yesterday evening. All wearing DHS fatigues etc. Naturally the assholes were parked in an ambulance parking spot. I called to report a strange vehicle parked there.


u/HolyMoleyGuacamoly • 4h ago

they appear to be staying at that marriott right next door. was by there for a bit and saw a ton of activity in and out of there of single white men in suvs with beards


Happy_Literature9493 • 3h ago

Copied and pasted from Safari reader mode [the Axios article:]

“Boston quietly prepares for an ICE surge Mike Deehan Boston City Hall is privately getting ready for a potential spike in Immigration and Customs Enforcement activity.

Why it matters: Even without a confirmed federal operation, the city is "planning for the unthinkable," according to Mayor Michelle Wu.

Escalating tensions and violence in other cities are deepening anxieties within immigrant communities and worsening the friction between sanctuary communities and federal authorities. The latest: Wu confirmed on WBUR this week that she is discussing enforcement scenarios with Boston Police leadership.

Her goal is to establish clear protocols to ensure local police resources are not co-opted into federal immigration efforts. Wu maintains that Boston police will not leak information to ICE, a stance she views as crucial to maintaining community trust. The big picture: Boston isn't alone in bracing for federal action.

Acting ICE Director Todd Lyons has stated plans for a larger presence in Boston, promising more agents following disputes over sanctuary policies. Past initiatives mobilized large-scale enforcement across Massachusetts. Zoom in: Unverified but persistent reports from residents and activists note a delivery of SUVs to the Burlington ICE Field Office last week.

Advocates interpret the arrival of three car carriers hauling SUVs as a sign that the local ICE branch is staffing up. What we're watching: If federal enforcement accelerates, pressure will mount on public-facing institutions and communities with sanctuary policies.

Courthouses are typically a flashpoint for arrests. City community centers and schools will need to know how to respond if agents appear at their doors. ICE likely won't limit large-scale enforcement to Boston. Municipalities with large immigrant populations like Chelsea, Everett, Lawrence, Revere and Lynn could also be in the crosshairs. Threat level: Activists have staked out the Burlington ICE office for months and will likely be among the first to know of any major rollout.

Expect throngs of Massachusetts residents to demonstrate against ICE if a surge happens here. The bottom line: While no operation has been officially confirmed, Boston is not waiting to find out — it is mobilizing now.”
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"What I 'erd, this nobby, 'iz bird got fingered over a tin o'beans, only shot the poor cow, didn't they? So, like, everybody's tooled up, an'..."

One panel from "V for Vendetta" by Alan Moore & David Lloyd, 1988. Page 193, middle row, middle panel.

V for Vendetta, Alan Moore & David Lloyd, 1988



 
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2026 Jan 6: Görkem Şen (Yaybahar on YT): Yaybahar III Nadiri



The description text:
The essence of gold was rare, he conquered with his virtue, offered his gifts and fell behind the sun...

Dedicated to the soul of my dear friend's father, Nadir Oğuz...
I am surmising that "Nadiri" means "Of Nadir". Yaybahar is the instrument, the artist is its inventor:
The name yaybahar (pronounced /jajba'har/) has Turkish origin. It is a composite of two words: yay means a "string" or a "coiled string" and bahar means the season "spring." According to Gorkem Sen, the name is derived from the idea of a new life or a new beginning. [1]
I assume this is the third one of its kind the artist has made.

Artist's website: https://www.gorkemsen.com/
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Interesting:

2025 Dec 31: DwarkeshPatel YT fea. Sarah Paine: Human Rights Killed Communism - Sarah Paine:



BTW, that's Sarah C. M. Paine, until very recently the William S. Sims University Professor of History and Grand Strategy and the Ernest J. King Professor of Maritime History, both, at the US Naval War College. She's an incredibly interesting speaker. Recommended.

(Dwarkesh Patel is this random dude who mistakenly thinks he's a podcaster and keeps trying to have other guests, but in actuality was put on Earth to bring Paine to the masses. He's got something like 14 hours of her up on his channel.)
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2025 Dec 24: ScienceDaily [press release?]: "Scientists reverse Alzheimer’s in mice and restore memory":
By examining both human Alzheimer's brain tissue and multiple preclinical mouse models, the team identified a key biological failure at the center of the disease. They found that the brain's inability to maintain normal levels of a critical cellular energy molecule called NAD+ plays a major role in driving Alzheimer's. Importantly, maintaining proper NAD+ balance was shown to not only prevent the disease but also reverse it in experimental models.
WARNING WARNING WARNING: Yes, there are OTC supplements for tinkering with your NAD+, but they are apparently/allegedly CARCINOGENIC (cause CANCER) at typical doses. DO NOT run out and do something stupid. Tinkering with your whole-body cellular metabolism has some gnarly failure modes. From this article:
Why This Approach Differs From Supplements

Dr. Pieper cautioned against confusing this strategy with over the counter NAD+-precursors. He noted that such supplements have been shown in animal studies to raise NAD+ to dangerously high levels that promote cancer. The method used in this research relies instead on P7C3-A20, a pharmacologic agent that helps cells maintain healthy NAD+ balance during extreme stress, without pushing levels beyond their normal range.
Continuing from the article:
NAD+ levels naturally decline throughout the body, including the brain, as people age. When NAD+ drops too low, cells lose the ability to carry out essential processes needed for normal function and survival. The researchers discovered that this decline is far more severe in the brains of people with Alzheimer's. The same pattern was seen in mouse models of the disease.

[...]

Amyloid and tau abnormalities are among the earliest and most significant features of Alzheimer's. In both mouse models, these mutations led to widespread brain damage that closely mirrors the human disease. This included breakdown of the blood-brain barrier, damage to nerve fibers, chronic inflammation, reduced formation of new neurons in the hippocampus, weakened communication between brain cells, and extensive oxidative damage. The mice also developed severe memory and cognitive problems similar to those seen in people with Alzheimer's.

[...]

This approach built on the group's earlier work published in Proceeding of the National Academy of Sciences USA, which showed that restoring NAD+ balance led to both structural and functional recovery after severe, long-lasting traumatic brain injury. In the current study, the researchers used a well-characterized pharmacologic compound called P7C3-A20, developed in the Pieper laboratory, to restore NAD+ balance.

The results were striking. Preserving NAD+ balance protected mice from developing Alzheimer's, but even more surprising was what happened when treatment began after the disease was already advanced. In those cases, restoring NAD+ balance allowed the brain to repair the major pathological damage caused by the genetic mutations.

Both mouse models showed complete recovery of cognitive function. This recovery was also reflected in blood tests, which showed normalized levels of phosphorylated tau 217, a recently approved clinical biomarker used to diagnose Alzheimer's in people. These findings provided strong evidence of disease reversal and highlighted a potential biomarker for future human trials.
Note, potential conflict of interest: the head of the lab, Dr Pieper, above, has a serious commercial interest in this proving out:
The technology is currently being commercialized by Glengary Brain Health, a Cleveland-based company co-founded by Dr. Pieper.
The actual research article:

2025 Dec 22: Cell Reports Medicine [peer-reviewed scientific journal]: Pharmacologic reversal of advanced Alzheimer's disease in mice and identification of potential therapeutic nodes in human brain by Kalyani Chaubey et al. (+35 other authors!):
Abstract:

Alzheimer's disease (AD) is traditionally considered irreversible. Here, however, we provide proof of principle for therapeutic reversibility of advanced AD. In advanced disease amyloid-driven 5xFAD mice, treatment with P7C3-A20, which restores nicotinamide adenine dinucleotide (NAD+) homeostasis, reverses tau phosphorylation, blood-brain barrier deterioration, oxidative stress, DNA damage, and neuroinflammation and enhances hippocampal neurogenesis and synaptic plasticity, resulting in full cognitive recovery and reduction of plasma levels of the clinical AD biomarker p-tau217. P7C3-A20 also reverses advanced disease in tau-driven PS19 mice and protects human brain microvascular endothelial cells from oxidative stress. In humans and mice, pathology severity correlates with disruption of brain NAD+ homeostasis, and the brains of nondemented people with Alzheimer's neuropathology exhibit gene expression patterns suggestive of preserved NAD+ homeostasis. Forty-six proteins aberrantly expressed in advanced 5xFAD mouse brain and normalized by P7C3-A20 show similar alterations in human AD brain, revealing targets with potential for optimizing translation to patient care.
Full text here: https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(25)00608-1
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Canonical link: https://siderea.dreamwidth.org/1891517.html


This is part of Understanding Health Insurance





The Three-Stage Model



When you have health insurance, you have a contract (health plan) with the insurance company that says that for the duration (the plan year) of the contract, you will pay them the agreed upon monthly fee every month (the premium), in exchange for them paying for your health care... some.

How much is "some"? Well, that depends.

To understand what it depends on, you have to understand the three-stage model that health plans are organized around.

This three-stage model is never described as such. It is implicit in the standard terms (jargon) of the health insurance industry, and it is never made explicit. There is no industry term (jargon) for the model itself. There are no terms (jargon) for the three stages. But health insurance becomes vastly easier to understand if you think about it in terms of the three-stage model that is hiding in just about every health plan's terms (agreements).

Read more: 12,170 (sic!) riveting words about health insurance in the US] )

This post brought to you by the 221 readers who funded my writing it – thank you all so much! You can see who they are at my Patreon page. If you're not one of them, and would be willing to chip in so I can write more things like this, please do so there.

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So, I, uh, got my RSI/ergonomics debugged!* I then promptly lost two days to bad sleep due to another new mechanical failure of the balky meat mecha and also a medical appointment in re two previous malfunctions. But I seem back in business now. The new keyboard is great.

Patrons, I've got three Siderea Posts out so far this month and it's only the 12th. I have two more Posts I am hoping to get out in the next three days. Also about health insurance. We'll see if it actually happens, but it's not impossible. I have written a lot of words. (I really like my new keyboard.)

Anyways, if you weren't planning on sponsoring five posts (or – who knows? – even more) this month, adjust your pledge limits accordingly.

* It was my bra strap. It was doing something funky to how my shoulder blade moved or something. It is both surprising to me that so little pressure made so much ergonomic difference, and not surprising because previously an even lighter pressure on my kneecap from wearing long underwear made my knee malfunction spectacularly. Apparently this is how my body mechanics just are.
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Canonical link: https://siderea.dreamwidth.org/1890494.html


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Hey Americans (and other people stuck in the American healthcare system)! Shopping for a health plan on your state marketplace? Boy, do I have some information for you that you should have and probably don't. There's been an important legal change affecting your choices that has gotten almost no press.

Effective with plan year 2026 all bronze level and catastrophic plans are statutorily now HDHPs and thus HSA compatible. You may get and self-fund an HSA if you have any bronze or catastrophic plan, as well as any plan of any level designated a HDHP.

2025 Dec 9: IRS.gov: "Treasury, IRS provide guidance on new tax benefits for health savings account participants under the One, Big, Beautiful Bill"
Bronze and Catastrophic Plans Treated as HDHPs: As of Jan. 1, 2026, bronze and catastrophic plans available through an Exchange are considered HSA-compatible, regardless of whether the plans satisfy the general definition of an HDHP. This expands the ability of people enrolled in these plans to contribute to HSAs, which they generally have not been able to do in the past. Notice 2026-05 clarifies that bronze and catastrophic plans do not have to be purchased through an Exchange to qualify for the new relief.

If you are shopping plans right now (or thought you were done), you should probably be aware of this. Especially if you are planning on getting a bronze plan, a catastrophic plan, or any plan with the acronym "HSA" in the name or otherwise designated "HSA compatible".

The Trump administration doing this is tacit admission that all bronze plans have become such bad deals that they're the economic equivalent of what used to be considered a HDHP back when that concept was invented, and so should come with legal permission to protect yourself from them with an HSA.

Effective immediately, you should consider a bronze plan half an insurance plan.

Read more [3,340 words] )

This post brought to you by the 221 readers who funded my writing it – thank you all so much! You can see who they are at my Patreon page. If you're not one of them, and would be willing to chip in so I can write more things like this, please do so there.

Please leave comments on the Comment Catcher comment, instead of the main body of the post – unless you are commenting to get a copy of the post sent to you in email through the notification system, then go ahead and comment on it directly. Thanks!
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Canonical link: https://siderea.dreamwidth.org/1890011.html

This is part of Understanding Health Insurance





Health Insurance is a Contract



What we call health insurance is a contract. When you get health insurance, you (or somebody on your behalf) are agreeing to a contract with a health insurance company – a contract where they agree to do certain things for you in exchange for money. So a health insurance plan is a contract between the insurance company and the customer (you).

For simplicity, I will use the term health plan to mean the actual contract – the specific health insurance product – you get from a health insurance company. (It sounds less weird than saying "an insurance" and is shorter to type than "a health insurance plan".)

One of the things this clarifies is that one health insurance company can have a bunch of different contracts (health plans) to sell. This is the same as how you may have more than one internet company that could sell you an internet connection to your home, and each of those internet companies might have several different package deals they offer with different prices and terms. In exactly that way, there are multiple different health insurance companies, and they each can sell multiple different health plans with different prices and terms.

Read more... [7,130 words] )

This post brought to you by the 220 readers who funded my writing it – thank you all so much! You can see who they are at my Patreon page. If you're not one of them, and would be willing to chip in so I can write more things like this, please do so there.

Please leave comments on the Comment Catcher comment, instead of the main body of the post – unless you are commenting to get a copy of the post sent to you in email through the notification system, then go ahead and comment on it directly. Thanks!

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Telling you things you didn't know you knew & pointing out things that you didn't know that you didn't know since at least 2004.

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