Email woes

Ok. I'm tired of Pine. I need a graphical POP3 client that supports multiple Email accounts is a decent way. I'm looking for something pretty significantly customizable (position of signature, different signatures between accounts and types of email - reply, forward, read read receipt). Email templates, sophisticated address-books, unique to each Email account.Something that handles separate accounts properly - that is to say keep completely different profiles for each account, along with settings, configurations and a whole separate directory structure for mail folders. So far I've tried

K-mail
Evolution
Sylpheed
EC
Mutt

All of these have failed my basic requirements ignominiously. When cursed to work on a Windows machine, I use The Bat! - which is the greatest Email client I've ever tried. Unfortunately, nothing I do seems to let me run it under Linux. It crashes Wine horribly, and even with addition of Kylix libraries, as someone recommended, things still go to hell in a hand-basket.

Any and all suggestions are welcome.