This is what has happened/what I think so far:

The IRL playing cards are awesome. There's a doctor lady I like the look of, so I hope she doesn't turn out to be a bitch. I don't understand the actual in-game card game. I read the rules multiple times and everything and I still don't get it. o_O

There are new gay equivalents of the Black Widow/Ladykiller perks. But I don't have that yet because I made Junko and I wanted to make her the same as in Fallout 3 so I'm going to make brand new characters just to test the different dialogue options and make Ranger Ghost my badass sexy lesbian girlfriend. There are quite a few female characters that I like actually, not many men because all the ones I've seen so far have had dodgy 1970s moustaches. Apart from Boone and he just has a weird big head.

There are different factions and you have a reputation with each in addition to your general karma, so it's more complicated than before. I've already made enemies of the prison-guys and the Legion (stupid roman armour wearing baddies who suck). And I'm friends with the town where you start and the NCR army people. Also, NPCs are mentioning the Brotherhood of Steel and I found a body wearing a scribe kind of robe so I'm hoping they'll be a faction too. But they're enemies of the NCR so if I have to choose between them, I'm probably still going to plump for the Brotherhood just for old time's sake XD

The bodyguard thing is a bit more interesting this time (but I want Fawkes back, he was my BFF ;3;) and you seem to be able to ask about themselves, what they think of the current situation and stuff. But mine won't talk to me anyway. C'mon, Boone. I just want to be your friend D: DON'T SHUT ME OUTTTT

I liked it when I went in Manny Vargas' house, which was unlocked (even though he wasn't in there) so it was OK for me to go in and not a crime. And EVERYTHING in there is 'acceptable' for you to use - there's mattresses on the floor, but he doesn't care if you sleep in his bed. You can get information from his terminal that he tries to make you do a quest for, his computer's not even locked. You can take all his food, use his toilet, whatever you like. BUT DON'T YOU DARE FUCKING SIT ON HIS COUCH. It's marked red, like it's a crime for you to use it?! What? I've slept in your damn BED but I can't sit on your sofa?! XD I dunno. It made me laugh anyway.

My best and favouritest bit so far though is a friendly Molerat called Snuffles. I mended his broken leg and I can ask him "How's it going?" even though he only says "whuff" to everything. Awwwww x3