Optical Photothermal Infrared Spectroscopy & Microscopy

Submicron IR with simultaneous Raman spectroscopy, co-located
Fluorescence and high-speed label free IR imaging

Advancing the frontiers of IR spectroscopy

Photothermal Spectroscopy Corp. is advancing the frontiers of vibrational spectroscopy and chemical imaging with breakthrough Optical Photothermal Infrared (O-PTIR) technology. O-PTIR overcomes key limitations of traditional FTIR including poor spatial resolution, time-consuming sample preparation, and spectral artifacts,

O-PTIR uniquely delivers multimodal capabilities for spectroscopy, imaging, and microscopy, combining sub-micron IR with simultaneous co-located Raman, and Fluorescence microscopy. Our mIRage products integrate these in easy to use, high throughput benchtop instruments.

Traditional IR vs Raman Spectroscopy — and how to carry out both simultaneously

Enable new research, solve key industrial challenges

Using the mIRage product family, scientists can exploit O-PTIR for high-impact research across life science, microplastics, materials science, bio-pharma and beyond.

For industry, mIRage solves critical problems and accelerates data acquisition, including characterising organic contamination, identifying material composition, and pinpointing failure analysis.

Need more information?

Discover how O-PTIR technology can elevate your research or help solve your toughest challenges. Our team are happy to assist and answer your questions.

Explore our products

stRAMos

stRAMos

Photothermal Stimulated Raman Microscope

Sub-300nm Photothermal Stimulated Raman Microscope. Powered by PhotoThermalSRS™

mIRage-HSi

mIRage-HSi

Laser Scanning O-PTIR Microscope

Sub-500nm Laser Scanning O-PTIR Microscope for High-Speed Imaging. With co-located Fluorescence and Raman spectroscopy.

mIRage-LS: sub-500nm O-PTIR with Co-located Fluorescence and simultaneous Raman spectroscopy

mIRage-LS

Highest resolution IR for life science research

The mIRage-LS addresses both life science applications and the broad application set of multiuser facilities where the most advanced vibrational spectroscopy needs are required.

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mIRage

High speed, label free, chemical imaging

A new submicron IR, high-speed widefield chemical imaging mode for measurement of a wide range of labelled and auto fluorescent samples covering cellular, bacterial and tissue applications.

Applications

Multi-modal optical photothermal Infrared spectroscopy is being applied successfully to an increasingly broad range of applications in both academic and industrial labs. Learn more about how O-PTIR can help you advance your research or help solve your critical problems.

Webinars

Meet mIRage-HSi, the next evolution of Optical Photothermal Infrared (O-PTIR) imaging, powered by laser-scanning optics for unmatched speed and productivity. Delivering FTIR transmission/ATR-like spectra at <500 nm spatial resolution, mIRage-HSi enables hyperspectral IR imaging in minutes and single-wavelength images in seconds — all in a non-contact, reflection-mode format with no spectral scattering artifacts.
Seconds, not hours: laser-scanning submicron 
IR imaging is here

News

Upcoming event

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ACS Spring 2026

We’re excited to announce that we will be attending ACS Spring 2026, March 22–26, 2026 in Atlanta, GA, USA! ACS Spring is a premier international meeting where the global chemistry community gathers for thousands of technical presentations, poster sessions, and an expo showcasing the newest scientific tools and technologies.
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“The capability of the mIRage system to provide submicron simultaneous IR+Raman is truly unique and offers significant advantages compared to other technologies. Moreover, Photothermal team have been amazing to work with!”

Tanya Hutter, Ph.D
Assistant Professor The University of Texas at Austin

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“The mIRage obtains valuable information about the structure of multilayered plastic films and ageing of adhesives not available to conventional FTIR and Raman. O-PTIR is valuable for the development of high-quality plastic recyclables”

Madina Shamsuyeva, Ph.D
Leibnez University Hannover, Germany. Institute for Plastics and Recycling Technology

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“Our first user experiment in the field of Alzheimer’s went so well that the researchers are submitting a manuscript to a high impact journal. The OPTIR is a disruptive technology.” 

Ferenc Borondics, Ph.D
Principal Beamline Scientist SOLEIL synchrotron France

Science portal

Science portal

Stay at the forefront of scientific innovation with our Knowledge Portal—a curated collection of technical articles, publication briefs, whitepapers, and webinar insights. Dive into groundbreaking research covering bioimaging, sub-micron IR analysis of microplastics, and single-molecule imaging with SERS/SIERA. Discover how Optical Photothermal Infrared (O-PTIR) spectroscopy is driving new advancements across multiple fields.

Need more information?

Discover how O-PTIR technology can elevate your research or help solve your toughest challenges. Our team are happy to assist and answer your questions.