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I-TASSER D-I-TASSER I-TASSER-MTD C-I-TASSER CR-I-TASSER QUARK C-QUARK D-QUARK DRfold DRfold2 DeepFoldRNA RNArefine LOMETS MUSTER CEthreader SEGMER DeepFold FoldDesign COFACTOR COACH MetaGO TripletGO ATGO IonCom FG-MD ModRefiner REMO DEMO DEMO-EM PPLM DMFold SPRING COTH Threpp PEPPI BSpred ANGLOR EDock BSP-SLIM SAXSTER FUpred ThreaDom ThreaDomEx EvoDesign BindProf BindProfX SSIPe GPCR-I-TASSER MAGELLAN ResQ STRUM DeepTherm DAMpred TCRfinder

TM-score TM-align US-align MM-align RNA-align NW-align LS-align TM-search Ouroboros EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred 3DRobot MR-REX I-TASSER-MR SVMSEQ NeBcon ResPRE TripletRes DeepPotential WDL-RF ATPbind DockRMSD DeepMSA DeepMSA2 rMSA FASPR EM-Refiner GPU-I-TASSER PRING

BioLiP HPmod E. coli UniBioMap GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS ProteinConform POTENTIAL RW/RWplus EvoEF HPSF THE-DB ADDRESS Alpaca-Antibody CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13 CASP14

Yang Zhang's Research Group

We are interested in:
I-TASSER model vs crystal structure of T0604_1, a CASP9 FM target
Understanding the structure and function of proteins and RNAs is fundamental to modern biology and medicine. Our lab develops advanced AI-driven algorithms to predict the three-dimensional structures of proteins and RNAs directly from their primary sequences, and to elucidate their biological functions through an integrated sequence–structure–function framework. We further combine large-scale computational modeling with biochemical and biophysical validation to design novel biomolecules—including proteins, peptides, and RNAs—with enhanced or entirely new functionalities beyond those found in nature. ( >> Read more ... ).

Job opening
  • Postdoctoral Position in AI-driven Biomolecular Structure Prediction: We seek talented and creative postdoctoral candidates interested in developing state-of-the-art computational algorithms for protein and RNA folding and structure prediction ( >> read more ... ).
  • Postdoctoral Position in Protein Design and Drug Discovery: We are seeking postdoctoral candidates interested in protein and peptide design, with wet-lab experience in protein engineering and structural determination ( >> read more ... ).
  • PhD Student Recruitment: We are currently recruiting highly motivated and talented students through multiple NUS PhD programs in Computer Science and Medicine ( >> read more ... ).
Zhang Lab news:

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