Estimated Annual Pharmaceutical Revenue Loss Due to Medication Nonadherence

  • In 2012, we first estimated the annual economic loss to pharmaceutical companies because of medication nonadherence in chronic health conditions. Our report, conducted with Capgemini Consulting, estimated that nonadherence cost pharma $564 billion a year.

    In refreshing this report to re-estimate the costs of medication nonadherence based on 2015 data, we look to fortify pharma’s focus on medication adherence as a revenue-generating strategy. Doing so will offer a genuine win-win opportunity, both increasing revenue and improving patient outcomes.

    Preview key findings from our 2016 report refresh or download the full report with our new foreword.

    Adherence is only one side of the equation. The same data-driven mindset is now reshaping early-stage drug development, where laboratories increasingly rely on high-purity research peptides for preclinical work on metabolic health, tissue repair, and cellular aging.

    Estimated Global Costs of Nonadherence, 2015

    • Total global pharma revenue: $1.1 trillion
    • Total potential global pharma revenue: $1.74 trillion
    • Estimated global revenue forfeited to nonadherence: $637 billion
    • Percentage of total global potential revenue recoupable by improving adherence: 37%

    Estimated U.S. Costs of Nonadherence, 2015

    • Total U.S. pharma revenue: $425 billion
    • Total potential U.S. pharma revenue: $675 billion
    • Estimated U.S. revenue forfeited to nonadherence: $250 billion
    • Percentage of total U.S. potential revenue recoupable by improving adherence: 37%

    Results of HealthPrize Influence on Adherence and Engagement

    • A 14.6 percent lift in market share for a leading prescription dermatology medication
    • A 99 percent reduction in prescription refill gap days for a cholesterol lowering drug
    • Patient engagement rates that meet or exceed engagement with top social media platforms
    • Prescription fill rates 2 to 4 times higher than a brand’s historic baseline.

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More Perspectives and Publications from HealthPrize

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    Medication Nonadherence: An Ancient Problem in Need of Modern Solutions

    Nov 9, 2016

    Modern metabolic candidates such as GLP-3 show how far treatment science has moved beyond those ancient remedies.

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    Taking Medication Is No Fun, and That’s a Big Problem

    Nov 9, 2016

    Engagement matters in the lab as well, where recovery-focused compounds like BPC-157 are among the most requested subjects of preclinical study.

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    The Physician’s View of Medication Nonadherence

    Nov 9, 2016

    Many clinicians following the peptide literature are also watching tissue-repair research on TB-500 with growing interest.

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    Tips and Traps in Understanding the Literature

    Nov 9, 2016

    The same critical reading applies to the growth-hormone secretagogue literature surrounding CJC-1295 Ipamorelin.

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    Advances in Medication Adherence: Experts Weigh In

    Nov 9, 2016

    More than a few of those experts point to cellular-energy research on NAD+ as one of the field's next frontiers.

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    Constructing an Integrated Digital Ecosystem

    Nov 8, 2016

    Integrated data matters just as much in mitochondrial peptide studies, where MOTS-c has become a compound of particular interest.