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shutterstock 2687181741
  • Blog post

For Methylation Sequencing, The Cancer Is In The Details

Learn how 6‑base sequencing, which separates 5mC and 5hmC detection, reveals subtle early epigenetic changes that dramatically improve stage I colorectal cancer detection compared with traditional methylation methods.

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Published scientific research
  • Publication

National Cancer Institute researchers show 6-base sequencing has the potential to transform liquid biopsy utility in informing clinical decisions without parallel tissue samples

6-base ctDNA 5mC/5hmC methylomics and clonal reconstruction infer tumour transcription and resistance phenotypes in metastatic prostate cancer

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Published scientific research
  • Publication

Researchers at Johns Hopkins use duet evoC to reveal genetic and epigenetic mechanistic biomarkers of catastrophic antiphospholipid syndrome 

Integrated genetic and methylation analysis reveals how either mutational or epigenetic silencing drives disease 

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Published scientific research
  • Publication

The importance of 5mC and 5hmC for biomarker discovery and biological insight is becoming clearer with the development of new methods for 6-base sequencing

This review covers the epigenetic influence of 5mC and 5hmC including recent findings connecting these modifications to disease processes and the potential of 6-base sequencing technologies to deepen our understanding of genetics and health.

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biomodal & Element Biosciences
  • News article

biomodal and Element Biosciences Combine Duet Multiomic and High-Throughput Sequencing Capabilities to Advance Clinical Research

biomodal, today announced at the AGBT 2026 General Meeting that biomodal’s duet multiomic solutions are compatible with Element Biosciences AVITI24™ 5D multiomics and AVITI™ sequencing instruments.

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fog london
  • News article

biomodal to showcase clinical research for earlier detection of colorectal cancer at The Festival of Genomics and Biodata London 2026

Dr. Sophie Kirschner, Associate Director, Translational Medicine, Early Oncology at AstraZeneca will present data using biomodal’s 6-base multiomics sequencing solution, duet evoC.

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biomodal
  • News article

biomodal Publishes Study in Nature Communications Medicine Highlighting Breakthrough in Earlier Colorectal Cancer Detection

Distinguishing 5mC and 5hmC, enabled through duet evoC and the 6-base genome, delivered an AUC of 0.95 for stage I colorectal cancer from liquid biopsy, improving the earlier detection of stage I colorectal cancer from cfDNA samples!

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Sunday Times top 100 tech companies 2026
  • News article

biomodal featured in The Sunday Times Top 100 Tech Companies 2026

biomodal has debuted in the top 10 of The Sunday Times Top 100 Tech Companies 2026.

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modality XPLR product sheet
  • Product sheet

modality XPLR product sheet

Download the product sheet for modality XPLR today.

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biomodal
  • News article

biomodal files patent infringement lawsuit against Watchmaker Genomics

biomodal announced it has filed a lawsuit against Watchmaker Genomics (“Watchmaker”) in the US District Court for the District of Colorado.

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Why epigenetics is important
  • Blog post

Why is epigenetics important? The role of epigenetics in biology and human diseases 

Explore the importance of epigenetics and how it shapes health, disease, and precision medicine through gene regulation, and DNA methylation.

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6-base genome reveals the reality of DNA methylation biomarkers of ageing
  • Poster

6-base genome reveals the reality of DNA methylation biomarkers of ageing

This study demonstrates the value of moving beyond legacy epigenetic sequencing technologies that provide a modC readout.

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