Science

In 1930, CV Raman won the Nobel Prize for discovering how light can show a molecule's composition. Now in 2025, a new MIT device is using the same methods to measure blood sugar without touching a drop of blood. Early tests show it can match the accuracy of today’s finger prick tests by shining near-infrared light on the skin - no needles, no implants. It could replace painful glucose monitors for 400 million diabetics. Here’s how👇 ▶ A glucose reading without breaking the skin ↳ A beam shines on the skin and detects glucose from the reflected signal. ↳ It uses Raman spectroscopy - a light-based method that reads the chemical makeup of tissue. ▶ A complex lab machine shrunk into a wearable ↳ Traditional Raman machines are huge and expensive. MIT shrunk it into a cell-phone sized wearable currently being tested. ▶ Proven head-to-head against invasive monitors ↳ In an MIT trial, a volunteer drank two glucose drinks. The device scanned every 5 minutes. Results matched commercial glucose monitors worn in parallel. ↳ The team is now preparing a larger study with diabetes patients at a local hospital. They’re now trying to: - Reduce the device to watch size - Ensure accuracy across different skin tones - Optimise it for day-long wear Diabetes affects over 400 million people worldwide, and finger-prick pain is still a daily reality. So if MIT’s work holds up in larger trials, I think noninvasive glucose monitoring could become one of the biggest breakthroughs in diabetes care since insulin. If this becomes real, do you think it will replace finger-prick tests? #entrepreneurship #healthtech #innovation

Today, I’m thrilled to share what I believe is the biggest breakthrough in microbiome science for a decade. Nature Magazine, the world's most influential scientific journal, has just published a scientific paper by ZOE's scientists, establishing the first reliable, repeatable, global way to measure the health of an individual’s gut microbiome. It represents the culmination of eight years of work at ZOE. Scientists have been trying to solve this puzzle for more than 20 years, right back to when they first discovered how important our gut microbes are for our health. It’s been achieved only because more than 34,000 ZOE members took part in this research. We’ve known for a long time that the microbiome is linked to cholesterol, inflammation, blood sugar control and even how we store fat. But we’ve never had a clear, evidence-based way to measure how healthy a microbiome actually is. This analysis finally delivers it, revealing a global ranking of microbes that works across populations, diets and environments. The insights are remarkable. Among the top 50 “good microbes” linked with better health, 22 were completely unknown to science until today, and most of the others have never been successfully grown in a lab. We also discovered clear links between these good microbes and health outcomes: healthy individuals carry around 3.6 more of these beneficial species, and people at a healthy weight carry about 5.2 more than those living with obesity. We also found a strong connection to diet. People eating healthier diets consistently have microbiomes that score better on this ranking. What we eat shapes our gut health, and now we can measure this relationship with unprecedented clarity. ZOE was created to enable microbiome research at a scale that traditional science has been unable to fund, and use this research to create actionable advice that can transform our gut health. This is a major milestone in that journey. I’m delighted to say that as a result, this breakthrough science is immediately available for the public to investigate their own microbiome through ZOE’s new Gut Health Test in the UK, and this is coming soon in the US. You can now receive not only a reliable measurement of how healthy your microbiome is as you change their diet, but also discover the health of clusters of gut microbes in your gut affecting metabolism, inflammation and more. To all our amazing ZOE members who have participated in our science: you made this possible. You are transforming our understanding of the microbiome. Thank you so much. I hope you feel as proud and excited as I do. I should note that your research is now published in Nature, which is the ultimate scientific accolade, and you can definitely brag about that with your friends! If you think this science could help others understand their health, I’d love for you to share it. You’ll find links to more details from our findings and access to the paper in the comments.

Agrivoltaics – combining land for solar and agriculture – is a genuine win-win. It allows a single piece of land to produce both food and clean energy at the same time. Around the world, farmers are finding that solar infrastructure creates microhabitats that boost resilience, improve yields and reduce water stress. For the agriculture: ✅ Shade from the panels lower ground temperatures and reduces evaporation. In arid areas, this has doubled or even tripled crop yields while cutting irrigation needs by half. ✅ Shade-tolerant crops like lettuce, kale, berries and broccoli thrive under reduced heat stress, especially during extreme weather. ✅ Higher soil moisture also promotes healthier pasture, leading to more nutritious forage for grazing animals. For solar operators: ✅ Sheep naturally keep vegetation under control, reducing mowing and maintenance costs and lowering fire risk. They also prevent plants from shading the panels. ✅ Crops underneath the panels help to cool the modules, improving performance on hot days. And the animals benefit too. A 3-year study of 1,700 sheep at the Wellington Solar Farm in NSW found the sheep produced higher quality wool and more of it. The arrays offer shade in summer, shelter during storms and cooler microclimates throughout the day. Economically it's a strong proposition: - Landowners gain a stable income stream while keeping land productive. - Developers access more viable sites with fewer permitting hurdles. - Communities retain agricultural land and benefit from local investment and tax revenue. And in the US, a significant "solar grazing" industry is emerging, where farmers become vegetation managers. They rent out flocks of sheep to solar farm owners and the sheep trim the vegetation. Agrivoltaics is showing that solar and agriculture don’t have to compete for land. They can thrive together – and create more value in the process. Image credit: Enel Green Power #energy #renewables #energytransition

Today in Cell, we published new research showing how AI can help accelerate cancer discovery. With GigaTIME, we can now simulate spatial proteomics from routine pathology slides, enabling population-scale analysis of tumor microenvironments across dozens of cancer types and hundreds of subtypes.   Developed in partnership with Providence and the University of Washington, our hope is that this work helps scientists move faster from data to insight, revealing new links between genetic mutations, immune activity, and clinical outcomes, and ultimately improving health for people everywhere. https://lnkd.in/dSpPdtzz

MIT just cleared 50% of Alzheimer's plaques using 40 Hz sound waves. No drugs. No surgery. Just precisely engineered frequencies making immune cells devour toxic proteins. Frequency is becoming medicine's most powerful tool. Think about that. While we've spent decades failing with Alzheimer's drugs, MIT researchers discovered something extraordinary: exposing brains to 40 Hz gamma frequencies activates microglia—the brain's cleanup crew—to clear amyloid plaques naturally. Mice regained memory. Human trials are showing promise. This isn't alternative medicine. It's FDA-approved precision. Traditional Brain Treatment: ↳ Invasive surgery with months of recovery ↳ Drugs that barely slow decline ↳ Blood-brain barrier blocking 98% of medications ↳ Essential tremor requiring skull opening The Frequency Revolution: ↳ 60% tremor reduction in one ultrasound session ↳ Same-day discharge, no incisions ↳ Drug delivery increased 5-fold to brain tumors ↳ 90+ clinical trials transforming neurology But here's what stopped me cold: Focused ultrasound doesn't destroy tissue—it tunes it. Opening the blood-brain barrier for exactly 4 hours to deliver chemotherapy. Synchronizing neurons at 40 Hz to trigger natural healing. Making Parkinson's tremors vanish while patients stay awake, go home that afternoon. We're not attacking disease anymore. We're conducting it away. What changes everything: ↳ Brain surgery without cutting ↳ Alzheimer's clearing without drugs ↳ Tumors targeted without systemic poison ↳ Healing through harmony, not harm The Multiplication Effect: 1 frequency device = surgery avoided 10 hospitals equipped = tremor wards emptying 100 conditions targeted = non-invasive becomes standard At scale = medicine's violent era ends Stanford uses ultrasound for depression. Johns Hopkins for addiction. Mayo Clinic for brain tumors. Each discovering that precisely tuned frequencies can reprogram biology better than any drug. We spent centuries cutting and poisoning disease. Now we're tuning it out of existence. Because when 40 Hz can clear plaques that billion-dollar drugs couldn't touch, and ultrasound can perform brain surgery without a scalpel, we're not just advancing medicine. We're using medical precision. Follow me, Dr. Martha Boeckenfeld for breakthroughs where physics becomes pharmacy. ♻️ Share if you want other to learn about new possibilities to fight Alzheimer. Resources: Gamma frequency entrainment attenuates amyloid load and modifies microglia" Authors: Li-Huei Tsai et al. NatureDecember 2016 DOI: 10.1038/nature20587. Gamma frequency sensory stimulation in mild probable Alzheimer’s dementia: Phase 2A pilot study" PLOS Biology, November 30, 2022 Evidence that 40Hz gamma stimulation promotes brain health,” Li-Huei Tsai, PLOS Biology, 2025.

🌍 NASA - National Aeronautics and Space Administration, in collaboration with data from the World Meteorological Organization, merges satellite observations, advanced models, and immense computing power to monitor aerosols in our atmosphere. These tiny, invisible solid or liquid particles — including black carbon (orange/red), sea salt (cyan), dust (magenta), and sulfates (green) — travel vast distances, affecting air quality, human health, climate, and visibility far from their source. 🔹 In South America, black carbon from wildfires burning in the Amazon rainforest drifts across the continent. 🔹 Over the Atlantic, massive plumes of dust from Northern Africa journey westward toward the Americas, influencing ecosystems, weather, and even hurricane formation. This striking visualization, powered by NASA’s Goddard Earth Observing System (GEOS) model and informed by WMO’s authoritative climate data, delivers realistic, high-resolution weather and aerosol insights. These data streams fuel #AI innovation and help provide customized environmental predictions — critical tools for #climateresilience and disaster preparedness #EW4ALL. ➡ A reminder: Every particle tells a story about the planet’s interconnected systems — and our shared responsibility to protect them

We’re planting trees — but losing biodiversity. Global efforts to restore forests are gathering pace, driven by promises of combating climate change, conserving biodiversity, and improving livelihoods. Yet a recent paper published in Nature Reviews Biodiversity warns that the biodiversity gains from these initiatives are often overstated — and sometimes absent altogether. Forest restoration is at the heart of Target 2 of the Kunming-Montreal Global Biodiversity Framework, which aims to place 30% of degraded ecosystems under effective restoration by 2030. But the gap between ambition and outcome is wide. "Biodiversity will remain a vague buzzword rather than an actual outcome" unless projects explicitly prioritize it, the authors caution. Restoration has typically prioritized utilitarian goals such as timber production, carbon sequestration, or erosion control. This bias is reflected in the widespread use of monoculture plantations or low-diversity agroforests. Nearly half of the Bonn Challenge’s forest commitments consist of commercial plantations of exotic species — a trend that risks undermining biodiversity rather than enhancing it. Scientific evidence shows that restoring biodiversity requires more than planting trees. Methods like natural regeneration — allowing forests to recover on their own — can often yield superior biodiversity outcomes, though they face social and economic barriers. By contrast, planting a few fast-growing species may sequester carbon quickly but offers little for threatened plants and animals. Biodiversity recovery is influenced by many factors: the intensity of prior land use, the surrounding landscape, and the species chosen for restoration. Recovery is slow — often measured in decades — and tends to lag for rare and specialist species. Alarmingly, most projects stop monitoring after just a few years, long before ecosystems stabilize. However, the authors say there are reasons for optimism. Biodiversity markets, including emerging biodiversity credit schemes and carbon credits with biodiversity safeguards, could mobilize new financing. Meanwhile, technologies like environmental DNA sampling, bioacoustics, and remote sensing promise to improve monitoring at scale. To turn good intentions into reality, the paper argues, projects must define explicit biodiversity goals, select suitable methods, and commit to long-term monitoring. Social equity must also be central. "Improving biodiversity outcomes of forest restoration… could contribute to mitigating power asymmetries and inequalities," the authors write, citing examples from Madagascar and Brazil. If designed well, forest restoration could help address the twin crises of biodiversity loss and climate change. But without a deliberate shift, billions of dollars risk being spent on projects that plant trees — and little else. 🔬 Brancalion et al (2025): https://lnkd.in/gG6X36WP

Double Materiality 🌎 Beyond compliance with key regulations like CSRD, double materiality assessments are essential for businesses to develop a comprehensive sustainability strategy. This framework helps companies identify how their activities impact society and the environment while also assessing how sustainability-related risks and opportunities affect financial performance. Impact materiality examines how a company’s operations influence people and the planet, covering topics like climate change, biodiversity, and social equity. Financial materiality focuses on how sustainability factors, such as regulatory changes, resource scarcity, or reputational risks, impact business performance and long-term growth. Some issues, like climate change mitigation, resource management, and labor conditions, fall under double materiality, meaning they are significant for both external impact and financial outcomes. By integrating double materiality, companies can align sustainability efforts with business objectives, risk management, and investor expectations, strengthening corporate resilience. This approach ensures that sustainability is not just a compliance exercise but a strategic tool to drive innovation, operational efficiency, and stakeholder trust. It also supports transparent reporting, helping businesses meet increasing demands from investors, regulators, and consumers for credible sustainability disclosures. Sectors like finance, manufacturing, and retail are already leveraging double materiality insights to guide decision-making, investment strategies, and supply chain management. This matrix developed by Vestas in their sustainability report is a great example of how to structure a double materiality assessment, clearly linking environmental and social impacts to financial performance and strategic decision-making. #sustainability #sustainable #business #esg #climatechange #doublemateriality #materiality

🌍 We Can’t Afford to Get Climate Policy Wrong—A Look at the Data Behind What Really Works 🌍 In the race against time to combat climate change, bold promises are everywhere. But here’s the critical question: Are the policies being implemented actually reducing emissions at the scale we need? A groundbreaking study published in Science, cuts through the noise and delivers the insights we desperately need. Evaluating 1,500 climate policies from around the world, the research identifies the 63 most effective ones—policies that have delivered tangible, significant reductions in emissions. What’s striking is that the most successful strategies often involve combinations of policies, rather than single initiatives. Think of it as the ultimate teamwork: when policies like carbon pricing, renewable energy mandates, and efficiency standards are combined thoughtfully, the impact is far greater than any one policy could achieve on its own. It’s a powerful reminder that for climate solutions the whole is indeed greater than the sum of its parts. Moreover, the study’s use of counterfactual emissions pathways is a game changer. By showing what would have happened without these policies, it provides a clear, quantifiable measure of their effectiveness. This is exactly the kind of rigorous evaluation we need to ensure that every policy counts, especially when we’re working against the clock. If we’re serious about meeting the Paris Agreement’s targets, we need to focus on what works—and this research offers a clear roadmap. Let’s champion policies that have proven to make a difference, because we don’t have time to waste on anything less. 🔗 Full study in the comments #ClimateAction #Sustainability #PolicyEffectiveness #ParisAgreement #NetZero #ClimateScience

Text understanding with #LLMs is useful but not enough for scientific understanding and discovery. In chemistry, in addition to text, chemical structure is essential to determine the properties of molecules. We have created the first multimodal text-chemical structure model: MoleculeSTM. It has an aligned latent space of both modalities. This allows the users to provide free-form text instructions to create molecules with arbitrary sets of properties. This enables zero-shot text-guided molecule editing (lead optimization) without the need to fine-tune the model for each new specification. Paper: bit.ly/4736BPH Code: bit.ly/4877YOS The core idea of MoleculeSTM is to align the chemical structure and textual description modalities using contrastive pretraining. The pivotal advantage of such alignment is its capacity to introduce a new paradigm of LLM for drug discovery: by fully utilizing the open vocabulary and compositionality attributes of natural language. To adapt it to a more concrete task, we focus on zero-shot text-guided molecule editing (aka lead optimization). Existing ML-based molecule editing methods suffer from data insufficiency issues. MoleculeSTM circumvents this by formulating molecule editing as a natural language understanding and interpolation problem, which is much easier to solve under the zero-shot setting. Such a novel paradigm is meaningful for addressing more practical drug discovery challenges. We will have more follow-up works along this LLM for the molecule/drug discovery research line. Please stay tuned! Shengchao Liu Chaowei Xiao Weili Nie Zhuoran Qiao Caltech