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Monday Articles 11/5: mRNA Therapeutics And Its Future
Monday Articles 11/5: mRNA Therapeutics And Its Future
Recent advances in mRNA molecular medicine has enabled mRNA-based therapeutics to enter into a new technological revolution of medicine. The success of those programs serves as a vital industrial validation for lipid nanoparticle (LNP) delivery systems.Rapid advancements have enabled the production of many functional complex proteins or peptide sequences in the human body by introducing mRNA as a therapeutic agent or as a vaccine. By delivering specific genetic sequences, we can now order the hu
Monday Articles 4/5: The Role of PCR in COVID-19 Diagnostics: A Molecular and Clinical Perspective
Monday Articles 4/5: The Role of PCR in COVID-19 Diagnostics: A Molecular and Clinical Perspective
AbstractThe COVID-19 pandemic required rapid deployment of accurate diagnostic tools to support disease detection and public health interventions. Polymerase Chain Reaction (PCR), particularly real-time reverse transcription PCR (RT-qPCR), became the gold standard for detecting COVID-19 due to its high sensitivity and specificity in identifying viral RNA (Corman et al., 2020).This article reviews the molecular principles of PCR, its clinical workflow, diagnostic significance, limitations, and it
Monday Articles 27/4: Unraveling the Myth: Does a “Squeaky Clean” Environment Weaken Our Immune System?
Monday Articles 27/4: Unraveling the Myth: Does a “Squeaky Clean” Environment Weaken Our Immune System?
IntroductionSince time-immemorial, the human immune system has been co-evolving alongside a diverse array of microorganisms that are omnipresent in our ancestral environment. Such microbes are tolerated by the immune system and become crucial for training regulatory T cells (Treg), which prevents the immune system from overreacting to harmless antigens. Nevertheless, there has been a surge in allergies especially among children in developed nations over the past few decades. Coincidentally, civi
Monday Articles 20/4: Epigenetics : Possible Cause of Intergenerational Trauma
Monday Articles 20/4: Epigenetics : Possible Cause of Intergenerational Trauma
IntroductionFor years, scientists have been trying to explain variance and inheritance through genetics with laws like Mendelian genetics laws or Law of Independent Assortment but the conundrum is that two identical twins with the exact genetic material can also look different even in traits that have a significant genetic component. For example, one twin might get a heart disease at 55 while the other twin runs marathons in perfect health. Scientists have been connecting these differences with
Wednesday Article (Bonus!): Dietary Nanoplastics: From Everyday Consumption to Cellular Disruption
Wednesday Article (Bonus!): Dietary Nanoplastics: From Everyday Consumption to Cellular Disruption
IntroductionA typical meal is expected to provide nutrients essential for survival—proteins, fats, carbohydrates, and micronutrients. However, in modern environments, it may also contain something far less expected.Imagine this: What if your daily diet already includes plastic— without you ever knowing it? While this may sound exaggerated, current estimates suggest that humans ingest nanoplastics regularly through food and beverages.These particles are not simply passing through the digestive sy
Monday Articles 13/04: Artificial Intelligence in Drug Discovery: Accelerating the Future of Medicine
Monday Articles 13/04: Artificial Intelligence in Drug Discovery: Accelerating the Future of Medicine
IntroductionTraditional drug discovery is infamously slow, expensive, and uncertain to response.Introduction of a new medical concept to the market typically takes more than a decade and costof over US $1 Billion with high attrition rates as failure of drug candidates in late-stage trials(Nature, 2024). Due to these challenges, researchers have adopted a computational toolespecially artificial intelligence (AI) in hopes of transformation the drug discovery paradigm. AIis made up of machine learn
Monday Articles 06/4: Organ On Chip: Putting the Human Body on a Microchip
Monday Articles 06/4: Organ On Chip: Putting the Human Body on a Microchip
IntroductionFor decades, biomedical research has had a repeated problem on clinical tests. If a newly discovered drug successfully cures a disease in an animal model, for example, a mouse, it should have a similar treatment effect, but when it enters human clinical trials, it fails to deliver any effects . How come? The simple explanation is that animals are simply not humans. Despite sharing a similar genome of 85%, Mice possess several characteristics which we don't such as hyper-active metabo
Monday Articles 30/3: The Microbiome: The Invisible WorldLiving Inside You
Monday Articles 30/3: The Microbiome: The Invisible WorldLiving Inside You
IntroductionDid you know that your body is home to trillions of microorganisms that play a crucial role in your health? This complex ecosystem, known as the Human Microbiome, consists of bacteria, viruses, fungi, and other microbes that live in and on your body—especially in your gut. Far from being harmful, many of these microorganisms are essential for maintaining normal bodily functions and overall well-being.What is the Microbiome?The human microbiome refers to the collection of microorganis
Monday Articles 23/3: Cancer Immunotherapy: Turning Your Immune System into a Weapon
Monday Articles 23/3: Cancer Immunotherapy: Turning Your Immune System into a Weapon
IntroductionCancer has long been treated using conventional methods such as chemotherapy, radiation, and surgery. However, a revolutionary approach known as cancer immunotherapy is transforming the way we fight cancer. Instead of directly targeting tumors, immunotherapy empowers the body’s own immune system to recognize and destroy cancer cells more effectively.What is Cancer Immunotherapy?Cancer immunotherapy is a treatment strategy that enhances or modifies the immune system to identify and at
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