The Jaramillo Lab: Engineering biological systems that learn

For decades, engineering biology has resembled traditional computer programming: we rationally design intricate genetic circuits to perform predefined functions. This approach, however, is brittle, difficult to scale, and struggles with the inherent complexity and noise of living cells. Our laboratory is pioneering a paradigm shift.

Inspired by the efficiency, adaptability, and robustness of the human brain, we are moving from designing biological logic to training biological matter. We develop foundational principles and platforms to engineer systems that can learn, adapt, and reprogramme themselves in response to their environment.

Our research aims to answer fundamental questions at the intersection of computer science, physics, and biology. Could we build a computer that grows, heals, and is truly alive? Can we harness the power of evolution to create on-demand, personalised therapeutics that overcome antibiotic resistance?

By creating novel genetic memory systems and developing technologies for accelerated evolution, we are laying the groundwork for the next generation of intelligent, living technologies.

We thank our current funders:

EIC:

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CaixaResearch:

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ONRG:

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AEI:

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We are located at the Instituto de Biología Integrativa de Sistemas (I2SysBio)

Find us at the office

Instituto de Biología Integrativa de Sistemas (I2SysBio)Parc Científic Universitat de ValènciaC/ Catedrático Agustín Escardino, 946980 Paterna (Valencia). Spain

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