Conventional and time-resolved cryo-electron microscopy reveal how NTSR1 dynamically engages and releases different G proteins, capturing over 20 intermediates and uncovering key mechanistic steps in GDP- and GTP-driven activation, subtype selectivity and distinct dissociation pathways.

A 4D imaging architecture using a large-scale, coherent LiDAR focal plane array comprising more than 0.6 million photonic components and associated electronics integrated on-chip can obtain coherent images at high frame rates over useful distances.

The acquisition of a parasitic anti-phage mobile genetic element, PLE11, showing potent anti-phage activity against cocirculating ICP1, and the subsequent evolution of ICP1 to escape this defense, are captured, revealing the molecular basis of the natural selection of a globally notable pathogen and its virus.

Individual supratentorial ependymoma tumour subgroups have two distinct progenitor-like cell states—neuroepithelial-like and embryonic-like—that are reminiscent of early human brain development and diverge in the extent of their neuronal or ependymal differentiation.

Marburgvirus glycoprotein binds to the endosomal receptor NPC1 in a distinct orientation with higher affinity compared with Ebola virus glycoprotein, accompanied by fusion-relevant rearrangements, enabling more efficient viral entry.