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Item type: Item , Access status: Open Access , Knowledge mobilization planning guides: a pragmatic synthesis and content analysis(2026-06-11) Zaccagnini, Marco; McCutcheon, Chris; Angel, Marina; Mrklas, Kelly J.; Graham, Ian D.Abstract Background Knowledge mobilization (KMb) aims to bridge the gap between research evidence and real-world application. While researchers, practitioners, and policymakers are increasingly expected to engage in KMb, many lack formal training and rely on publicly available guides. Despite their widespread use, little is known about the quality, evidence base, or development processes of these resources. This study examined the availability, content, and construction of online KMb guides relevant to health disciplines. Methods We conducted a pragmatic synthesis simulating how individuals typically search for KMb resources, using Google Plain to identify freely accessible, English-language guides offering concrete planning steps. Inclusion was based on relevance to health-related audiences, such as researchers, clinicians, managers, and policymakers. Two reviewers screened the first 50 results per search string, with calibration exercises to ensure consistency. Data were extracted using a piloted tool and analyzed through conventional content analysis to identify themes and guide characteristics. Findings The search was conducted in two time periods (pre-2019 and 2019–2025), yielding 52 eligible guides, of which 42 were available for full extraction. Most guides originated from Canada (69%) and used “knowledge translation” as the primary term (43%). Only a third cited evidence to support their guidance (33%) or effectiveness of strategies (24%), and none included a process for future updates. Most guides clearly outlined planning steps (91%) and were visually accessible (88%). Common steps included selecting a KMb method (93%), identifying the audience (86%), and evaluating the process (81%). Few addressed plan sustainability (19%). Discussion This review found significant variability in the quality, transparency, and theoretical grounding of publicly available KMb guides. Many lacked clear development methods, cited evidence, or plans for updates, limiting their credibility and long-term usefulness. Only a minority referenced KMb theories or provided evidence to support their recommendations. We developed a meta-guide and reflective questions to support the creation and evaluation of more transparent and evidence-informed KMb resources.Item type: Item , Access status: Open Access , Managing hydraulic fracturing-induced seismicity in the Duvernay shale: Triggering mechanisms, influencing factors, and practice-oriented mitigation strategies(2026-08-17) Hui, Gang; Pi, Zhiyang; Ge, Chenqi; Li, Ye; Chen, Zhangxin; Wu, Dan; Lu, Yunli; Ni, Feng; Yang, Xing; Zhang, Yujie; Gu, FeiAbstract This review provides a Duvernay-focused synthesis of hydraulic fracturing (HF)-induced seismicity, integrating geological datasets, case studies of significant events, coupled poroelastic simulations, and machine-learning-based factor ranking. While the three underlying triggering mechanisms—pore pressure increase, poroelastic stress perturbation, and aseismic slip—are well established, their relative contributions and quantitative thresholds have not been systematically constrained for the Duvernay. It is worth noting that: (1) aseismic slip is a frequent precursor to moderate-sized events in this basin; (2) poroelastic stress changes often dominate over direct pore pressure diffusion at distances > 1 km from the injection well; and (3) using a normalized seismic moment release per unit injected volume, the induced-seismicity potential correlates most strongly with distance to the Precambrian basement (< 250 m) and formation overpressure (> 15 kPa m⁻1). A comparative analysis reveals that Duvernay events occur predominantly within sedimentary cover, are spatially linked to Devonian reef margins, and exhibit lower maximum magnitudes for a given injected volume. To bridge the gap between academic modeling and industrial practice, we propose a tiered mitigation framework: (1) pre-drill geological screening using high-resolution fault and basement mapping; (2) operational constraints (e.g., limiting single-stage injection volume to < 15,000 m3 in high-risk zones); (3) a predictive traffic-light system that integrates real-time Coulomb stress calculations; and (4) field-ready decision tools (nomograms, risk scoring cards). These findings underscore that proactive, data-driven, regionally tailored risk management is essential for sustainable unconventional resource development in seismically susceptible basins like the Duvernay.Item type: Item , Access status: Open Access , Bilateral vs unilateral chronic rhinosinusitis in HIV: distinct clinical and inflammatory characteristics from a surgical cohort(2026-06-12) Shao, Shan; Guo, Xinwei; Zhang, Miao; Dong, Xuejin; Wang, Xiangdong; Bao, Shiping; Xu, YuanAbstract Background The European Position Paper on Rhinosinusitis and Nasal Polyps (EPOS) 2020 classification for chronic rhinosinusitis (CRS) hasn’t been extensively characterized in people living with HIV (PLWH), a population with a high burden of sinonasal disease. This study aimed to characterize the clinical features of surgical HIV-associated CRS and compare bilateral versus unilateral disease. Methods This single-center, retrospective surgical cohort study included 60 consecutive patients with HIV-associated CRS requiring endoscopic sinus surgery between January 2020 and June 2025 at Beijing You’ an Hospital, a national designated center where a large proportion of HIV-associated CRS surgical cases have been managed in China. Demographic, clinical, laboratory (including eosinophil/neutrophil counts), and radiological (Lund-Mackay score, E/M ratio) factors were analyzed. Univariate comparisons were performed using the Mann–Whitney U test for continuous variables and χ2 test (or Fisher’s exact test) for categorical variables to identify factors associated with bilateral CRS. Results The cohort comprised 60 PLWH (median age 36.0 years; 95.0% male), with bilateral CRS being predominant (78.3%). The most common sinonasal symptoms were nasal blockage (96.7%), purulent rhinorrhea (48.3%), and hyposmia (40.0%). Patients with bilateral CRS had a significantly higher prevalence of nasal blockage and sleep disturbance compared to those with unilateral disease (p = 0.04 and p = 0.03, respectively). Univariate analysis revealed significant differences between bilateral and unilateral CRS in eosinophil parameters (both count and percentage: p < 0.001), neutrophil percentage (p = 0.02), Lund-Mackay CT scores (p = 0.007), and the ethmoid-to-maxillary sinus ratio (p = 0.04). Conclusions In PLWH with CRS requiring surgery, bilateral disease was the predominant presentation and was associated with greater radiographic severity and a higher peripheral eosinophil count. These findings suggest potential clinical relevance of the EPOS 2020 anatomic classification in this population, but this requires prospective validation.Item type: Item , Access status: Open Access , The role of AI-assisted drug repurposing in neurological disorders: a systematic review of validation strategies, challenges and opportunities(2026-07-10) Chen, Fengshou; Wang, Limei; Liu, Hao; Khan, Qasim; Tang, Bing; Bao, NarenAbstract Neurological disorders refer to a diverse group of conditions that affect the brain, peripheral nerves, and spinal cord and impair socioemotional, cognitive, motor, and sensory functions. Alzheimer’s disease (AD), Multiple Sclerosis (MS), Parkinson’s disease (PD), Huntington’s disease (HD), and Amyotrophic Lateral Sclerosis (ALS) are some of the well-known neurodegenerative diseases that affect millions of people worldwide. Despite the advanced technologies and nano-drug delivery systems, the success rate of developing drugs for neurological disorders is significantly low. Among several constraints, including gastrointestinal irritation, rapid metabolism, and low stability, the blood-brain barrier (BBB) emerges as one of the key challenges in the development and application of drugs against neurological disorders. These challenges necessitate innovative approaches to develop cost-effective therapeutic strategies. Drug repurposing, the discovery of new therapeutic benefits of existing drugs, is a promising drug discovery approach for discovering potential treatment options for complex neurological disorders. This review aims to explore the advanced and significant progress in drug repurposing for major neurological disorders, including MS, AD, PD, ALS, HD, stroke, and neuropsychiatric conditions. It places an explicit emphasis on discussing the potential role of artificial intelligence (AI)-assisted drug repurposing and understanding of the biological mechanisms in discovering new drugs for these neurological conditions. This also examines current challenges in drug repurposing and provides a critical review of the available opportunities and limitations in AI-assisted drug repurposing. Graphical abstractItem type: Item , Access status: Open Access , Grounded, Governed and Graced: Foundational Practices for Hospital Visitation Volunteers Serving with the United Church of Canada A Dissertation Submitted to the Committee for Advanced Pastoral Studies in Candidacy for the Degree of Doctor of Ministry(2023-05) Simmins, GeoffreyABSTRACT Grounded, Governed and Graced: Foundational Practices for Hospital Visitation Volunteers Serving with the United Church of Canada Geoffrey Simmins Three questions undergird the structure of this dissertation project, which has as its goal to develop a facilitation program for religious community hospital volunteers. How can we equip hospital volunteers so that they feel confident and ready to undertake their roles? How do we make information provided to them not only palatable but memorable, so that it can continue to inform and inspire the volunteers? How can adult learning theory and practices be employed to heighten a sense of empowerment and inspiration in the volunteer’s ongoing work, so that the materials and techniques become a dynamic tool that can be applied in many different circumstances? The dissertation adds new elements to an existing literature on training and sustaining hospital visitation volunteers by organizing a facilitation program with a three- part structure—Grounded, Governed and Graced, described here as the Three-G model. These consist of being Grounded in self-knowledge and an awareness of the Holy; Governed by church and hospital regulations; and Graced by the reciprocal gifts of visiting. The Three-G model informs engagements with case-studies focusing on role- playing and practices of extemporaneous prayer and enable volunteers to gain fluency and confidence for diverse visitation scenarios. Despite the project’s focus on the United Church of Canada, its outlook is ecumenical.
