I assume your $n\times n$ matrix, $M$, is sufficiently large -- in particular $n\geq 7$. You can directly calculate the determinant of $M$ when $n\leq 6$.
$\Sigma:=\begin{bmatrix}
B & \mathbf 0 & \mathbf 0 \\
\mathbf 0 & I_{n-6} & \mathbf 0 \\
\mathbf 0 & \mathbf 0 & C
\end{bmatrix}$
with
$B:=\begin{bmatrix}
1 & 0 & 0 \\
0 & \frac{1}{3} & 0 \\
0 & 0 & \frac{1}{3} \\
\end{bmatrix}$ and $C:=\begin{bmatrix}
\frac{1}{3} & 0 & 0 \\
0 & \frac{1}{3} & 0 \\
0 & 0 & 1 \\
\end{bmatrix}$
$\implies \frac{1}{3^{4}}\cdot \det\big(M\big)=\det\big(M\Sigma\big)\neq 0$
where the right hand side holds by Taussky's refinement of Gerschgorin Discs since $(M\Sigma)$ is irreducible, weakly diagonally dominant and the dominance is strict in at least one row [row 4]. I gave a proof of Taussky's refinement under "Optional Second" here: Prove that this block matrix is positive definite
addendum: a different argument (assuming $n\geq 5$):
$M= H+S= \frac{1}{2}\big(M+M^T\big) +\frac{1}{2}\big(M-M^T\big)$
noting that the (i.) the Skew matrix is extremely sparse with its 1st column linearly independent amongst all other columns & the same holds for its nth column and (ii.) the Hermitian matrix is diagonally dominant with positive diagonals so $H\succeq \mathbf 0$-- i.e. for $\lambda \lt 0$ you have $(H-\lambda I)=(H+\vert \lambda\vert I)$ is strictly diagonally dominant so invertible and apply spectral theorem. (You could deduce irreducible $H\succ \mathbf 0$ by Taussky's refinement at this stage which then implies $\dim \ker M =0$ but I'll give a different approach.)
suppose that $\mathbf 0\neq \mathbf x \in \ker M$
$\implies \mathbf x^T H\mathbf x =0\implies \max\big(\vert x_1\vert, \vert x_n\vert\big)\gt 0 \text{ & }\mathbf x \in \ker H $ $\implies M\mathbf x = H\mathbf x +S\mathbf x =S\mathbf x \neq \mathbf 0 \text{ (contradiction)}$
the 1st implication holds since $\mathbf x^T H\mathbf x = \mathbf x^T M\mathbf x= 0$; the 2nd implication holds since the $n-2\times n-2$ middle principal submatrix of $H$ is strictly diagonally dominant with positive diagonals (i.e. is positive definite) & $H\succeq \mathbf 0$; finally $S\mathbf x \neq \mathbf 0$ by (i.) since the first and/or last component of $\mathbf x$ is not zero