A platform for tracking the changes in gene expression and chromatin accessibility that follow interference with specific genes has been developed. The platform, called PerturbFate, was applied to skin-cancer cells and showed that different genetic perturbations associated with tumour resistance push cells into a shared dedifferentiated state.

A type of activity in the brain’s cortex, called high gamma, is widely used in studies of brain function, but its origin has long been debated. An experiment using a brain–machine interface now shows that high-gamma activity is generated mainly by synchronized neuronal inputs, rather than outputs, which has implications for the interpretation of neuroscientific studies.

A system of protein binders directs energy-generating organelles to targeted cells, potentially improving ways to treat mitochondrial dysfunction.

A large language model that is trained using AI outputs can inherit undesirable behaviours, even if they are not directly referenced in the training data.