ROCKET improves experimental structure elucidation by integrating implicit structural knowledge from OpenFold, a trainable reimplementation of AlphaFold2, with X-ray crystallographic and cryo-electron microscopy experiments.

CREsted is an efficient and user-friendly toolbox for analysis, modeling and design of cell-type-specific enhancers across diverse species.

We demystify the appeals process at Nature Methods.

A nascent group of researchers sees planetary health as an urgent reason to bridge the molecular and planetary scales. This is shaping their strategies, methods, collaborations and outlook about their fields.

sm-PORE-cupine combines SHAPE-based chemical probing with nanopore-based direct RNA sequencing to identify RNA structural ensembles in the SARS-CoV-2 genome and the Candida albicans transcriptome.

PinkyCaMP is a red genetically encoded calcium indicator with improved brightness and photostability. Derived from mScarlet, it does not exhibit photoswitching upon blue light illumination and is therefore compatible with green sensors as well as blue-light-sensitive optogenetic tools.

Multi-Embed is an interpretable framework that enables integrated analyses of histological images and multilayer molecular profiles.

A collection of antigen-stabilizable fluorescent nanobodies becomes fluorescent upon binding to their intracellular targets and enables background-free multicolor imaging and biosensing in living systems, revealing protein dynamics, metabolites and signaling across cellular and in vivo models, including the zebrafish embryo and mouse brain.

NirFAP680 is a near-infrared fluorogen-activating protein that has an order of magnitude greater cellular brightness and superior photostability compared to currently available NIR FAPs and fluorescent proteins in both single- and two-photon excitation and allows robust imaging of proteins in live cells and in vivo.

Orthrus is an RNA foundation model pretrained via contrastive learning based on splicing isoforms and orthologous transcripts. This pretraining strategy leads to its strong performances in various tasks about RNA properties and functions, distinguishing Orthrus from other genomic foundation models.

Researchers often have to move — within their country or across the world. Packing up and moving an established lab is a logistic and emotional challenge.