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Publications
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Pregnane X receptor antagonist MI-891 reduces hepatic triglycerides in PXR-CAR-CYP3A4/3A7-humanized mice
Biomedicine & Pharmacotherapy 197: 119168 (2026)
Hepatic steatosis is a major metabolic concern associated with activation of the pregnane X receptor (PXR), a nuclear receptor known to promote lipogenesis and lipid accumulation in the liver. While the lipogenic effects of PXR agonists are well documented, there is no comprehensive data on the metabolic consequences of PXR inhibition. Here, we evaluated the impact of MI-891, a novel human PXR antagonist and inverse agonist, on hepatic lipid metabolism in high-fat diet (HFD)-fed PXR-CAR-CYP3A4/3A7-humanized female mice. Lipidomic analysis revealed a significant reduction in hepatic triglyceride levels and a shift in their saturation profile after MI-891 treatment. In parallel, RT-qPCR analysis showed a down-regulation of lipogenic genes (Scd1, Thrsp, Acaca) and lipid-droplet-associated genes (Plin2, Hsd17b13), suggesting suppressed fatty acid and triglyceride synthesis and diminished lipid droplet storage. The primary PXR target gene CYP3A4 was downregulated at both the mRNA and…
Machine-Learned Extrapolation of Quantum Mechanical Energies in Implicit Solvent from Short to Long Oligopeptides
Journal of Chemical Information and Modeling 2026: Early View
Triptycene-grafted helicenes: modular synthesis and key properties
Chemical Communications 2026: Early View
Targeting the Membrane-Embedded Rhomboid Protease GlpG: A Multimodal Strategy for Inhibitor Discovery and Mechanistic Insight
Angewandte Chemie International Edition 65 (10): e14067 (2026)
Adsorption-Driven Symmetry Lowering in Single Molecules Revealed by Ångstrom-Scale Tip-Enhanced Raman Imaging
Journal of the American Chemical Society 148 (9): 9375–9381 (2026)
