Lucas Arnoldt

About

I'm a PhD student in Fabian Theis' lab at Helmholtz Munich, supported by the German National Scholarship Foundation. My work sits at the intersection of deep learning and genomics, where I am building models that are not only accurate but interpretable. I previously trained with Roland Eils at the Digital Health Center (BIH & Charité, Berlin), and spent six months in David Baker's lab at the Institute for Protein Design (University of Washington), where I worked on generative protein design.

I'm always happy to chat about research, collaborations, or ideas. Feel free to reach out.

Research Interests

Publications

^# denotes equal / co-first contribution

• Preprint

  An Interpretable Omnigenic Neural Network Architecture for the Human Genome

  Upmeier zu Belzen J., Arnoldt L., Hollmann N., Herrmann L., Nguyen K.M., …, Theis F.J., …, Eils R.

  medRxiv (2026) · doi: 10.64898/2026.07.28.26359187

• Preprint

  The Human Pancreas Cell Atlas Defines a Healthy Reference Framework for Disease Contextualization and Translational Benchmarking

  Parikh S.^#, Strobl D.C.^#, Jimenez S., Beckmann J.L., Arnoldt L., …, Theis F.J.

  bioRxiv (2026) · doi: 10.64898/2026.06.22.733853

• Preprint

  annbatch unlocks terabyte-scale training of biological data in anndata

  Gold I.^#, Fischer F.^#, Arnoldt L., Wolf F.A., Theis F.J.

  arXiv (2026) · doi: 10.48550/arXiv.2604.01949

• Published · Lancet Digital Health

  A Predictive Atlas of Disease Onset from Retinal Fundus Photographs

  Buergel T.^#, Loock L.^#, Steinfeldt J.^#, …, Arnoldt L., …, Wild B., Eils R.

  Lancet Digital Health (2026) · doi: 10.1016/j.landig.2025.100962

• Preprint

  Biologically Informed Variational Inference Enables Interpretable Cell Phenotyping and Discovery

  Arnoldt L., Upmeier zu Belzen J., Herrmann L., Nguyen K., Ishaque N., Theis F.J., Wild B., Eils R.

  bioRxiv (2025) · doi: 10.1101/2025.06.10.657924

• Published · Nature Biotechnology

  Multistate and Functional Protein Design Using RoseTTAFold Sequence Space Diffusion

  Lisanza S.L.^#, Gershon J.M.^#, Tipps S.W.K.^#, Sims J.N.^#, Arnoldt L.^#, Hendel S.J., … Baker D.

  Nature Biotechnology (2024) · doi: 10.1038/s41587-024-02395-w

Software