Wojtek Treyde

@WTreyde

PhD student in computational chemistry at the University of Oxford

Joined October 2024

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Wojtek Treyde
@WTreyde
Jun 16
New paper out! We show that SARS-CoV-2 PLpro can be inhibited in a substrate-selective manner, preferentially blocking deISGylation over viral polyprotein processing. Computational modelling suggests a mechanism for the observed substrate selectivity.
Substrate‐Selective Inhibition of the SARS‐CoV‐2 Papain‐Like Protease: Inhibition of Hydrolysis of...
From chemistry-europe.onlinelibrary.wiley.com
Wojtek Treyde
@WTreyde
Jun 5
Excited to share our work on cephalosporin derivatives as potent SARS-CoV-2 Mpro inhibitors! doi.org/10.1016/j.ejme… I contributed the computational modelling to help explain how subtle changes to the cephalosporin scaffold affect potency and mechanism. @IneosOxford
Wojtek Treyde
@WTreyde
Apr 10
Excited to share our @CellPressNews paper on “computational motifs” (doi.org/10.1016/j.patt…)! We show how computational challenges cut across fields, present prototypes to tackle them, and offer recommendations for the community Big thanks to @ARIA_research & everyone involved
Wojtek Treyde
@WTreyde
Nov 8, 2025
Thrilled to see our work on β-lactams and SARS-CoV-2 Mpro published! It’s been a pleasure contributing the computational modelling to this collaboration, which highlights how subtle chemical modifications can shift inhibition mechanisms: doi.org/10.1039/D5MD00…
Wojtek Treyde
@WTreyde
Jun 10, 2025
💻🧪CompMotifs: Hack the Sciences (lu.ma/apsqlxlj) is wrapped! 70+ hackers, 12 projects, £1.5k worth of prizes, 5 great speakers (incl. @PetarV_93!) and epic ideas. Powered by @ARIA_research and friends. 👉compmotifs.com and lu.ma/compmotifs.