Luke O'Connor

@Luke0connor

Human genetics and applied mathematics - genetic architecture and genealogical algorithms - Assistant Professor @HarvardDBMI

Cambridge, MA

Pinned
Luke O'Connor
@Luke0connor
Aug 17
Now published @CellGenomics cell.com/cell-genomics/…
Luke O'Connor
@Luke0connor
Aug 7, 2025
New preprint on a surprising question - with a pangenome reference, *what is a genetic variant?* biorxiv.org/content/10.110… With Pouria Salehi Nowbandani, Shenghan Zhang, Haoyang Hu, and Heng Li @lh3lh3
Luke O'Connor
@Luke0connor
Aug 31
Excited to share our preprint: what is the penetrance spectrum of coding mutations in autism?
Ajay Nadig
@NadigAjay
Aug 31
How often is autism caused by de novo changes to the genome? What is the spectrum of penetrance across autism-associated genes? What can we expect from future autism gene discovery? I'm pleased to share a new preprint where we develop new statistical methods to answer these Qs.
Luke O'Connor
@Luke0connor
Jul 1
Very excited to share a powerful new method, graphREML, for common-variant heritability partitioning and enrichment from GWAS sumstats, now published in @NatureGenet Led by 1st author Hui Li, co-supervised with @XihongLin
1
Luke O'Connor
@Luke0connor
May 8
Now published @AJHGNews cell.com/ajhg/abstract/…
Luke O'Connor
@Luke0connor
Jul 16, 2025
New preprint with Guy Sella on the question: what is polygenicity? biorxiv.org/content/10.110…
So excited to share our latest preprint, introducing a powerful genealogical compression algorithm for biobank-scale genetic data With Amber Shen, Xinran Wang, and Nick Mancuso @nmancuso_ biorxiv.org/content/10.648…