2026 HOTLIST
For introductions to these startups or to request the password to access startup pitch decks, please contact:
Christina Drake
[email protected] 734-997-8661
Additional data is available in the master Hotlist database via Airtable:
This group of startups is curated from hundreds of recommendations made by Renaissance partners (universities, incubators, accelerators, angel networks, and venture funds). To be considered for the Hotlist, startups participate in Renaissance’s annual event, UnDemo Day. The list is refreshed after each UnDemo event.
Current Hotlist companies are shown below, sortable by sector and with embedded links where their pitch decks may be viewed if available.
| Company Name | Primary Sector | Description |
|---|---|---|
| Adrenaline Interactive | Marketing / Advertising / Sales |
Adrenaline helps advertisers like Reebok reskin Roblox and Fortnite via our award winning Virtual Product Placement software.
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| AG3 Labs, Inc. | Automotive / Mobility |
AG3 Labs builds low-cost autonomous drone swarms, bringing back American-made innovation for defense and industrial sensing. Our CHAOS stack enables scalable, AI-driven mission execution.
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| Alisio | FinTech |
Alisio is a vertical AI agent platform helping manufacturers across the U.S. and LatAm get paid faster, qualify for more contracts, and grow cross-border.
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| Arbor Battery Innovations | Energy / Energy Efficiency |
Arbor Battery Innovations is scaling advanced lithium-ion battery technologies. Our patented process integrates seamlessly with existing manufacturing lines and enables 10 min fast charging.
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| Arbor Halides | Energy / Energy Efficiency |
Arbor Halides is focused on manufacturing complex salt products for advanced energy applications. These include advanced nuclear reactors, concentrated solar, thermal energy storage, and defense tech.
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| ArtiMed Inc. | Healthcare - Services or Health IT |
ArtiMed's AI-enabled end-to-end solution helps uninsured/underinsured individuals with disabilities receive Medicaid or Medicare + income.
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| Atterx Biotherapeutics | Healthcare - Biotech/Pharma |
Specialty pharmaceutical company developing innovative products for the prevention and treatment of multi-drug resistant bacterial infections. Current focus is on prevention of CAUTIs.
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| Authsnap, Inc. | Healthcare - Services or Health IT |
Authsnap automates clinical appeals for denied medical claims using a proprietary AI engine that blends EHR data with payer policy, helping health systems (and patients) recover lost revenue.
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| Beye.ai | Information Technology (IOT, Enterprise, Internet) |
Beye is an AI-native generative BI platform for mid-market companies that harmonizes data into an AI-ready source of truth and delivers natural-language answers in seconds, accelerating workflows.
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| Block Harbor Cybersecurity | Information Technology (IOT, Enterprise, Internet) |
Block Harbor delivers an AI-powered platform that automates the entire cybersecurity lifecycle for the "moving world" of connected vehicles and soon -- all forms of physical AI robots.
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| Bloom | Advanced Manufacturing / Materials |
Bloom is a B2B marketplace platform that connects hardware brands with vetted supply chain and service partners across the build, deliver, and service lifecycle.
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| BRCĒ | Advanced Manufacturing / Materials |
BRCĒ uses patented material-tech to develop a range of performance & safety gear, with data-backed product designs in strategic alliances with Under Armour & DEWALT, mentorship from Nike & Techstars.
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| Brief | Information Technology (IOT, Enterprise, Internet) |
Brief transforms documents into a living network that thinks and works like you do.
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| ChemCom | Advanced Manufacturing / Materials |
ChemCom builds advanced control systems and cloud-based data services (SaaS) designed to automate and optimize chemical process management — modernizing traditionally manual practices.
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| ChurchSpace | Consumer Products |
ChurchSpace helps churches generate extra streams of income by transforming underutilized church real estate into high-impact, hyper-local commercial space.
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| Citrimer | Advanced Manufacturing / Materials |
Citrimer is a chemicals company developing carbon-negative chemicals and materials from agricultural waste without a green premium.
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| ConStrat AI | FinTech |
ConStrat AI unifies banking, accounting & construction data to track costs, predict overruns, and guide decisions with AI modeling and a proprietary credit score for SMB contractors.
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| Coordinista | Healthcare - Services or Health IT |
Nurse designed, intelligent, field care delivery platform for decentralized teams
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| CSIsim | Education Tech |
CSIsim builds safe, intelligent AI. Our ConstrainedAI® powers avatars, tutors & tools—trained only on trusted, domain-specific data.
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| CytoHub Inc. | Healthcare - Biotech/Pharma |
CytoHub is a frontier biotech company building an AI-driven platform to cure heart disease using stem cell-derived human mini-hearts mimicking native heart physiology with 96% fidelity.
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| Decimal Code | Healthcare - Services or Health IT |
Decimal Code is an automated medical coding spinout from Michigan Medicine, focused on the perioperative space.
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| DriveEase | Automotive / Mobility |
DriveEase is an EV rental service solving range anxiety and charging delays for long-distance travel. We offer unlimited, instant vehicle swaps, making intercity EV journeys seamless and stress-free.
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| Echelor | FinTech |
Echelor is the AI-powered Agentic CFO for small and medium-sized businesses (SMBs), delivering real-time financial strategy, execution, and clarity.
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| Elite Care Technologies | Healthcare - Services or Health IT |
Elite Care uses intelligent automation to streamline care management workflows-reducing administrative burden, improving patient outcomes, and unlocking untapped revenue for clients.
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| Elroi | Information Technology (IOT, Enterprise, Internet) |
Elroi is a privacy-first data exchange platform that empowers consumers to control and monetize their data, while enabling enterprises to access consented insights in compliance with global regulation
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| Enspired Solutions | Advanced Manufacturing / Materials |
Enspired Solutions is solving the global issue of PFAS contamination in water. A patented and EPA award-winning approach offers superior cost/performance value by completely destroying PFAS molecules.
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| Equinox Biologics | Healthcare - Biotech/Pharma |
Equinox Biologics is an early stage biotechnology company developing myeloid cell engagers designed for the treatment of mild to severe autoimmune diseases.
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| Extrinsic Immunity Therapeutics | Healthcare - Biotech/Pharma |
Extrinsic Immunity Therapeutics is a preclinical-stage biotech company developing immunotherapies that target NETs in the tumor microenvironment, with its lead program NETrolyze focused on TNBC.
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| Fortis Management LLC | Advanced Manufacturing / Materials |
Start-up with potential to solve the affordable housing crisis throughout the entire Midwest and beyond. Access to patented, revolutionary SIP technology that will change housing construction forever.
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| Fourth State Technologies Inc. | Energy / Energy Efficiency |
Fourth State is developing a scalable water treatment system to decompose a range of contaminants including PFAS.
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| FreightRoll Inc. | Information Technology (IOT, Enterprise, Internet) |
FreightRoll's Intelligent YardOS transforms your yards into self-service hubs for truck drivers, resulting in better throughput, better labor utilization, less paper usage and happier drivers
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| GEKOT Robotics Inc. | Automotive / Mobility |
Active safety technology for vehicles such as bikes, scooters, and golf carts. Think collision avoidance as found in modern cars but tailored to these vulnerable light vehicles.
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| General Orbit | Advanced Manufacturing / Materials |
General Orbit builds next-generation satellite systems with advanced software and hardware. We're simplifying satellite production and reducing costs, helping to power the industrialization of space.
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| Genomenon, Inc. | Healthcare - Services or Health IT |
Genomenon is an AI-driven genomic data company at the forefront of transforming genetic data and Real World Evidence into actionable insights for clinical diagnostics & precision medicine development.
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| HAPPE Spine | Healthcare - Medical Device |
HAPPE Spine is an early stage company commercializing a proprietary biomaterial and manufacturing process platform for creating bone-integrating implants that actively participate in healing.
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| Hawk Technologies | Automotive / Mobility |
Hawk Technologies provides engineered solutions through innovative product and process development, blending engineering with software and manufacturing for defense and commercial industry.
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| Health Exam | Healthcare - Services or Health IT |
Health Exam uses AI to help outpatient clinics access key patient data, improve documentation, reduce denials, and boost revenue—making care safer, faster, and more accurate.
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| Iconavize, LLC | Automotive / Mobility |
Iconavize is redefining the driving experience with AI that turns car confusion into clarity. Just snap a photo of any vehicle button or symbol, and get instant, easy-to-understand answers.
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| Intermode | Automotive / Mobility |
Intermode building autonomous mobile ground robots for defense, agriculture, and last mile delivery. We are cheaper than chinese products while being built like true commerical grade products.
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| Kall Morris Inc (KMI) | Automotive / Mobility |
KMI: an in-space logistics company providing innovative relocation services via an optimized-mobility spacecraft fleet to extend & enhance vital missions for civilian, commercial, & national security.
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| Keryx Inc. | Healthcare - Biotech/Pharma |
Keryx is developing an RNA therapeutic that restores failing insulin cells to prevent type-2 diabetes entirely. Led by an RNA biologist, we've built a lab and generated proof-of-concept data.
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| M3D, Inc | Healthcare - Medical Device |
Real-time radiation devices for healthcare applications
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| Machine AI Solutions | Information Technology (IOT, Enterprise, Internet) |
Machine AI Solutions is a SaaS company helping small to mid-scale manufacturers shift from manual operations to smart, data-driven operations with real-time insights & AI analytics
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| Marel Power Solutions | Energy / Energy Efficiency |
Marel’s compact power stacks make power conversion faster, cheaper, and easier – dramatically reducing size, weight, and semiconductor use across mobility, grid, datacenter, and defense.
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| MediCool Technologies, Inc | Healthcare - Medical Device |
MediCool is developing a novel painless therapy for dangerous cardiac arrhythmias including Post-operative A-Fib, a common, expensive and potentially morbid complication following cardiac surgery.
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| Mentavi Health | Healthcare - Biotech/Pharma |
Mentavi provides online mental health diagnostics and treatment with a modern care model. Mentavi completed a major clinical trial validating the telehealth-based diagnostic approach to ADHD.
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| Michigan Space Technologies | Advanced Manufacturing / Materials |
Michigan Space Technologies is an advanced aerospace and defense company focused on the development of next-generation propulsion systems, AI-enabled command platforms, and rapid-launch infrastructure
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| Modal Motors Inc. | Automotive / Mobility |
Modal Motors, Inc. exists to manufacture our patent-pending non-rare-earth magnet advanced technology electric motors and inverters in Michigan that substantially outperform competitive Chinese motors
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| MoiiAI Inc. | Information Technology (IOT, Enterprise, Internet) |
Moii AI-powered video analytics transform security cameras into intelligent vision assets—optimizing operations, mitigating risks and delivering real-time actionable insights.
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| Motmot, Inc | Automotive / Mobility |
Motmot is a Water and GovTech Engineering company that addresses the challenge of limited infrastructure visibility in underground water pipe networks by deploying an Autonomous Underwater Robot.
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| Myconaut | Information Technology (IOT, Enterprise, Internet) |
Myconaut is a regenerative technology company based in Marquette, Michigan, pioneering bio-based solutions for environmental remediation through fungi, microbes, and carbon-smart materials. By integra
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| Neferdata | Information Technology (IOT, Enterprise, Internet) |
Neferdata: The Shopify of SMB AI. We deliver a comprehensive ecosystem and robust platform, empowering a new wave of AI entrepreneurs to effortlessly launch market-ready solutions.
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| Neumo | Automotive / Mobility |
Neumo delivers real-time driver insights from a headrest sensor that detects fatigue, distraction, and impairment - what cameras miss - to help carmakers and fleets build safer vehicles.
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| NeuroAIgent Inc | Information Technology (IOT, Enterprise, Internet) |
NeuroAIgent delivers secure, on-prem Agentic AI agents that can be trained without LLMs and require no technical expertise. Our platform automates repetitive business tasks through self-learning agent
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| Noble Gas Systems Inc. | Energy / Energy Efficiency |
Noble Gas is a developer and producer of efficient, safe, and cost-effective high-pressure gas storage vessels for mobility, industrial, and energy sectors.
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| Ollivate Inc. | Healthcare - Services or Health IT |
Ollivate is the Duolingo of healthcare education, delivering gamified, on‑the‑go learning for healthcare students to prep for board exams and and for providers to earn continuing education credits.
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| OneSix Energy Inc. | Energy / Energy Efficiency |
OneSix Energy produces low-cost, clean hydrogen and valuable carbon black. We're working to decarbonize heavy industry & mobility with a modular, low CapEx, low OpEx system.
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| Onlay AI | Healthcare - Services or Health IT |
Onlay is the first and only full end-to-end automation platform for dental front desks, handling insurance,claims, and payments in one seamless system. Already in dental practices, built by dentists
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| Pachira | FinTech |
Pachira is the high tech solution to the trillion dollar gift card industry- fully customizable, multi brand cards perfectly blending personalization and convenience.
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| Plain Sight | Marketing / Advertising / Sales |
Plain Sight is transforming the $100B corporate events industry by streamlining the way brand sponsors do business with event creators at scale.
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| ProbeTruth, Inc. | Information Technology (IOT, Enterprise, Internet) |
AI deepfake detection for videos, audios and images using reasoning and learning.
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| RIVET Work | Information Technology (IOT, Enterprise, Internet) |
Labor planning software for construction specialty contracting businesses.
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| Robobuoy Inc. | Media / Entertainment / Sports |
Robobuoy is a robotics company disrupting the marine industry. Our Bots have served as racecourse marks, golf targets, special event boundaries and military drones.
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| RoboWorkX Inc | Automotive / Mobility |
World's first and only of all-electric autonomous multi-utility robots for commercial outdoor maintenance.
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| SampleServe, Inc. | Information Technology (IOT, Enterprise, Internet) |
Software for digital chain-of-custody of environmental samples and crime scene evidence collection/lab submittal. Used in environmental/municipal projects and crime scene evidence management.
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| Sequestro, Inc. | Advanced Manufacturing / Materials |
Sequestro, Inc. is an advanced materials manufacturer revolutionizing the water purification market with its innovative, bio-based PFAS adsorbents based on patented wood-fiber functionalization.
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| Shifty | Education Tech |
Shifty is a mobile-first training and scheduling platform that helps restaurants train better, engage employees, and reduce turnover, built by 35+ year veteran operator.
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| SignetRisk Analytics, Inc. | Information Technology (IOT, Enterprise, Internet) |
SignetRisk Analytics is focused on bringing next generation cyber risk data and analytics to the cyber security and risk management industry.
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| Strut Motors, Imc. | Automotive / Mobility |
Strut Motors builds electric Light Utility Vehicles (LUVs) — right-sized, modular, autonomy-ready vehicles optimized for daily local trips under 10 miles, starting at $10K.Our mission is to democratiz
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| SWEPT AI | Information Technology (IOT, Enterprise, Internet) |
Swept is a supervision platform for AI agents and agentic workflows, helping teams catch errors, prevent drift, and stay in control of autonomous systems. It acts like observability for AI, offering d
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| Tansy AI, Inc. | Healthcare - Services or Health IT |
Tansy AI helps self-insured employers cut costs by guiding employees to schedule care, navigate benefits, and engage in preventive health—across platforms and for the whole family.
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| The Led Lion | Advanced Manufacturing / Materials |
Led Lion Co LLC is a construction innovation firm advancing 3D concrete printing to build infrastructure faster, safer, and more cost-effectively.
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| Traxen Inc | Automotive / Mobility |
Traxen develops intelligent technologies for commercial vehicles, including advanced driver assistance systems and AI-powered cruise control, to improve fuel efficiency, safety, and automation.
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| VITIA | Healthcare - Services or Health IT |
VITIA empowers patients with chronic conditions through an AI-driven platform that simplifies care management, by integrating education, access, and motivation with with loyalty-based incentives
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| Voltaic Marine, Inc. | Automotive / Mobility |
Voltaic Marine builds high-performance electric boat platforms with modular design and robotic manufacturing for recreational, commercial, and defense markets.
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| Waldo Solutions Inc. | Information Technology (IOT, Enterprise, Internet) |
Waldo is a cloud-based forestry operations platform that digitizes and streamlines the timber supply chain—from harvest to mill—to enhance efficiency, accuracy, and regulatory compliance.
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