Are gallbladder neuroendocrine tumors really aggressive?
A new study in Endocrine Pathology suggests most GB-NETs are small, low-grade, and indolent, with tumor size and grade emerging as key predictors of metastatic risk.
How does adrenocortical carcinoma become metastatic?
New research suggests that widespread chromosomal alterations occur early and are retained throughout tumor evolution, identifying chromosomal instability as a key driver!
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Is it time to move beyond the typical/atypical carcinoid classification? Using data from >700 pulmonary NETs, researchers developed a reproducible grading system (Ki-67 and mitotic count) that outperformed traditional histology in predicting outcome.
New molecular insights into GEPNET G3: Multi-omic profiling shows these tumors are biologically distinct from neuroendocrine carcinomas, retain features of well-differentiated NETs and harbor potentially actionable alterations in 25% of cases.