Patrick Bryant

@Patrick18287926

Dedicated scientist.

Stockholm, Sweden

patrickbryantlab.github.io

Joined November 2020

200 Following

1,825 Followers

Replies Reposts Media

Patrick Bryant
@Patrick18287926
Nov 3
su.se/english/divisi…
Patrick Bryant
@Patrick18287926
Oct 28
The Structural History of Eukarya (SHE): The first proteome-scale phylogeny constructed entirely from 3D structure. We computed 300 trillion alignments across 1,542 species to map the tree of life. Now published!!! science.org/doi/10.1126/sc…
Patrick Bryant
@Patrick18287926
Oct 28
The Structural History of Eukarya (SHE): The first proteome-scale phylogeny constructed entirely from 3D structure. We computed 300 trillion alignments across 1,542 species to map the tree of life. Now published!!! science.org/doi/10.1126/sc…
2
Patrick Bryant
@Patrick18287926
Oct 20
Looks great! Can't wait to try it - congrats @FrankNoeBerlin !!! Super cool with the peptide binding
Frank Noe
@FrankNoeBerlin
Oct 20
Public preview of BioEmu2! @MSFTResearch AI for Science’s new foundation model for biomolecular structure, dynamics and function. Open weights, MIT license. github.com/microsoft/bioe… Movie: BioEmu2-simulated binding of intrinsically disordered peptide PUMA to MCL-1 receptor. 🧵⬇️
Patrick Bryant
@Patrick18287926
Aug 23
Can molecular glues be designed rather than discovered by chance? We built EvoBind-multimer to design small (6-10 AAs) cyclic peptide glues directly from protein sequences. We validate de novo VHL-KRAS and VHL-BRD4 glues in cells and patient-derived tumoroids.
GIF
3
Patrick Bryant
@Patrick18287926
Jun 24
This is spot on. Going from specifying input sequenced to gene names is useless
Josie Zayner
@josiezayner
Jun 24
No scientist ever said, "you know what I need? An AI agent to do molecular docking and protein structure prediction." Why are we pretending this is progress?
Quote
NVIDIA Healthcare
@NVIDIAHealth
Jun 23
Science is entering a new era - one where AI agents can do scientific work. 🧬 Today NVIDIA is launching the BioNeMo Agent Toolkit - an open, agent-ready toolkit that gives any AI agent callable tools for protein structure prediction, molecular docking, generative chemistry,
3

Patrick Bryant

Patrick Bryant’s posts