In a brief independent assessment, we find that Kimi K3.1 Pro, the latest model from Moonshot AI, is second among open-weight models on our Bio Capabilities Index (BCI) and 19th overall. Its score of 149 places it just behind Kimi K3 (150) and well behind the highest-scoring
A lack of “tacit knowledge” is often treated as the barrier that stops biological misuse. But we think that assumption is doing more work than the evidence supports. Drawing on ~60 years of collective lab experience, we unpack what “tacit knowledge” means and how much of a
Thread & blog posts from UK AISI on our recent collaborative efforts:
1) ReproBAIT, a new benchmark to assess general purpose AI model capabilities at reproducing published biological AI tools, and
2) research on the strengths and limitations of pre-training data filtering on
Study 1: Can AI coding agents rebuild a biological AI tool from just its paper?
With @SecureBio, we built ReproBAIT to test leading coding agents. For two of three tools, agents reproduced a key function on a single GPU - often for $4–$20.
In our brief independent assessment, Gemini 4 Argon is the second-highest scoring model on SecureBio's Bio Capabilities Index: 169, behind only Claude Opus 5 (176). On BioTIER, Argon refuses 87.8% of hazardous prompts, up from 62.8% for Gemini 3.1 Pro. Read the full model note