Welcome to the SATB2 Gene Foundation, Inc.

The SATB2 Gene Foundation, Inc. was established to enrich the lives of individuals with SATB2-associated syndrome, including those diagnosed with the condition and their families, through support, research and education.  Our mission will be met by raising awareness about the characteristics of SATB2-associated syndrome, providing support to families, and supporting research in a wide range of issues related to SATB2-associated syndrome.

What is SATB2-Associated Syndrome?

SATB2-associated syndrome (aka Glass Syndrome) is caused by problems in the SATB2 gene located on chromosome 2q33.1, which is a neurodevelopmental disorder. SAS affects the individuals through global developmental delays.  Most significant is the absence of speech, or significantly delayed/affected speech.  We often see palate abnormalities – including cleft palate or high arched palate.  Other key characteristics of SAS are dental issues – missing adult teeth and/or oversized front teeth; low bone density, and behavioral issues.  We are seeing a growing number of our patients with seizures and sleep difficulties.