Millions Are Living Without Answers. We’re Changing That.
People with ME/CFS and Long Covid often go without answers or treatment. We fund and accelerate the research and advocacy to make these diseases better understood, diagnosable, and treatable
How We Accelerate Progress
Solve M.E. takes a holistic approach to research and advocacy, catalyzing efforts through our various programs to make ME/CFS, Long Covid, and other “long haul” diseases better understood, diagnosable, and treatable.
We are the largest U.S. peer-reviewed provider of private competitive research funding exclusively for ME/CFS, and the partner of choice for strategic, collaborative relationships with patients, researchers, government officials, and other disease organizations across the globe.
Fund Breakthrough Research
Support scientists uncovering causes, treatments and cures.
Turn Patient Data into Discovery
Turn lived experience into insights that drive research forward.
Making Impact
From research to collaboration, we are accelerating breakthroughs in ME/CFS and Long Covid.
research studies funded, advancing science breakthroughs
About ME/CFS & Long Covid
Myalgic encephalomyelitis (ME), formerly known as chronic fatigue syndrome (CFS), is a chronic neuroimmune disease that profoundly limits daily life and is often triggered by an infection.
Long Covid describes a collection of lingering symptoms following COVID-19.
Common Symptoms
Crippling fatigue, post-exertional malaise (PEM), cognitive dysfunction, sleep disruption, and pain that can significantly impact daily life.
Do I Have ME/CFS or Long Covid?
Take our short quiz to learn if your symptoms may be consistent with ME/CFS or Long Covid.
Advancing Research with Dr. Akiko Iwasaki
Dr. Iwasaki of Yale School of Medicine, our first Catalyst Award recipient, is uncovering the biological drivers of Long Covid and related conditions.

Simmaron Research Receives Catalyst Award
This study explores low-dose rapamycin as a potential treatment for ME/CFS, Long Covid, and related conditions.

New Catalyst Awards Drive Breakthrough research
Solve M.E. is funding two new studies to advance urgently needed treatments and diagnostics for ME/CFS and Long Covid.

Understanding the Latest Research
Our Science Spotlight breaks down the latest ME/CFS and Long Covid research into clear, easy-to-understand insights.

Help Turn Research Into Reality
Donations from people like you allow Solve M.E. to fund the most promising research and initiatives without delay.
Who We Are
Solve M.E. is nonprofit advancing research into ME/CFS, Long Covid, and related chronic conditions. We collaborate with researchers, clinicians, policymakers, and patient communities to accelerate diagnosis, treatment, and breakthroughs that can improve millions of lives.