Translational Pulmonary
& Immunology Research Center

Where Big Data Meets Big Medicine

As an independent research institute, TPIRC stays focused on one goal: Improving patient outcomes through science and data.

AREAS OF FOCUS

Infant & Lung Development: Bronchopulmonary Dysplasia (BPD)

Rare Lung Diseases: Cystic Fibrosis | Bronchiectasis | Airway Disorders

Exercise & Lung Longevity: Sports Lab | Lung Capacity | Performance Optimization

Food Molecules & Gut Health: Food Allergies, GI Conditions, Nutrition-Linked Disorders

Immune System Health: Primary & Secondary Immunodeficiencies

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Infant & Lung Development

Advancing early lung and neurodevelopment in infants with BPD through early risk identification, data-driven care, and research.

Rare Lung Diseases

Improving outcomes for rare and complex lung diseases through personalized diagnostics, real-world data, and targeted research.

Exercise & Lung Longevity

Studying lung performance under physical stress to optimize lung capacity, recovery, and long-term respiratory health.

Food Molecules & Gut Health

Exploring how food molecules affect the gut and immune system to advance personalized treatments for food allergies and related conditions.

Immune System Health

Advancing understanding of immune system disorders to improve diagnosis, treatment, and patient outcomes.

TPIRC

a rare disease institute

How It All Connects

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At TPIRC, every part of our work is connected. Diagnostics provide detailed patient insights, which feed into Data Science & AI to uncover patterns that guide Clinical Care. Research builds on these outcomes to drive Discovery, creating new tools and treatments. Unlike traditional models, these discoveries loop back to improve diagnostics, care, and data, continuously enhancing patient outcomes.

How it all connects

powered by Data, AI and Discovery

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At TPIRC, every part of our work is connected. Diagnostics provide detailed patient insights, which feed into Data Science & AI to uncover patterns that guide Clinical Care. Research builds on these outcomes to drive Discovery, creating new tools and treatments. Unlike traditional models, these discoveries loop back to improve diagnostics, care, and data, continuously enhancing patient outcomes.

How Research Becomes Impact

Clinical translation

We translate research into real-world clinical action through Lung & Allergy Health Associates (LAHA), ensuring scientific insights directly improve diagnosis, treatment, and outcomes.

Novel Diagnostics

Applying tools like Impulse Oscillometry (IOS) and Exercise CPET to assess lung health earlier and more precisely.

Clinical Programs

Secondary Immune Deficiency and Reproductive Immunology.

Credentials

Delivering evidence-based care backed by Joint Commission Disease-Specific Certification in Pediatric Asthma.

discovery science

Our discovery science investigates the biological mechanisms that drive lung, immune, and food-related disease, generating the evidence that fuels innovation across TPIRC.

Molecular & Cellular Research

Studying immune signaling, inflammation, and tissue development to understand disease at its root.

Integrated Research Programs

Advancing parallel investigations across lung biology and immune-mediated responses to accelerate insight.

Biobank-Driven Discovery

Leveraging patient-derived samples to identify biomarkers and mechanisms linked to long-term health outcomes.

Applied math & AI

We use advanced mathematics and artificial intelligence to connect data across diagnostics, care, and research, enabling prediction, precision, and safer personalization.

Systems Modeling & Forecasting

Applying AI/ML to model biological systems and disease progression.

Precision Medicine Frameworks

Developing mathematical methods that move beyond population averages toward individualized care.

Regulatory & Safety Implications

Supporting responsible innovation through data-driven insights that enhance patient safety and clinical decision-making.

Discovery Science

Foundational research uncovering the mechanisms that drive lung, immune, and food-related disease.

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Lung Biology & Pediatric Pulmonary Disease

Investigating lung development, inflammation, and injury at the molecular and cellular level.

BPD Macrophage Characterization

Studying immune responses in developing lungs during non-invasive ventilation.

BPD CPAP Model

Evaluating CPAP’s role in reducing lung injury in premature
infants.

Cystic Fibrosis Research

Quantifying neutrophil infiltration and inflammatory pathways driving disease progression.

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Food Protein & Immune
Biology

Understanding how immune and food protein interactions influence tolerance, allergy, and disease outcomes.

Mechanistic Immune Studies

Examining antibody class switching and B cell behavior using Biobank samples.

Plant Biology Research

Characterizing allergenic proteins in almond and walnut to understand prevalence and risk.

Psychosocial Impact

Studying how anxiety and behavioral factors affect treatment response.

The TPIRC Biobank

Patient participation enables the discovery of biomarkers and mechanisms linked to long-term immune tolerance and disease outcomes.

Through our integrated research infrastructure, each contribution becomes part of a dynamic data ecosystem that connects clinical outcomes with underlying immune patterns. This approach allows our team to translate individual patient data into broader insights that inform precision therapies, disease modeling, and future standards of care across immune-mediated conditions.

Every Breakthrough Starts With a Story

Fuel groundbreaking
medical research!

At TPIRC, transformative care starts with a simple act of giving. Your support helps us deliver cutting-edge solutions to families who have nowhere else to turn.

Our partnerships