#omicron is spreading 2-5-times faster only among vaccinated and boosted population, but not among unvaccinated.
Basically, omicron completely cancels out any effect vaccine+booster had on #deltavariant transmission among #vaccinated.
#COVID19
medrxiv.org/content/10.110โฆ
David Usharauli
17.1K posts
Immunologist & Biotech Co-Founder @Tregeutix on a mission to harness the power of Tregs & microbiota | Calling on visionary investors to join our journey ๐
- When the hospitalization rate is 70% of the pre-vaccine period in a time when 85% of eligible people are fully vaccinated, people should look around and ask some tough questions. #COVID19 #vaccine #VE bloomberg.com/news/articles/โฆ via @business
- The rate of loss of neutralizing Ab after the 3rd dose is even faster than after the 2nd dose (in NHPs). #mRNA #vaccine #boosterdose #COVID19 Protection against SARS-CoV-2 beta variant in mRNA-1273 vaccineโboosted nonhuman primates science.org/doi/10.1126/scโฆ
- "Our results suggest that once hospitalised the risk of death among #vaccinated and #unvaccinated patients in #Norway is similar." We still have no clear understanding of what determines #vaccine efficacy. Data are all over the place. #mRNA
- A Treg-centered model of self-nonself discrimination. 1/ A few days ago, Science published a major study on Foxp3+ Tregs. Here's my analysis & conceptual takedown of its implications. ๐งต๐ #immunology #tolerance #Foxp3 #Tregs
- Genome-wide CRISPR screen in human T cells reveals regulators of FOXP3 Shimon Sakaguchi, et al. #immunology #Foxp3 #Tregs
- Prior #SARSCoV2 infection provides protection against both symptomatic and severe #DeltaVariant and #Omicron reinfections equivalent to 2-3 dose vax. It's time to acknowledge the equivalency of prior infection and 2-3 dose vaccination. #COVID19 medrxiv.org/content/10.110โฆ
- Replying to @HelenBranswellit is unlikely they put hold because one individual showed adverse reaction to vaccine when they may have already vaccinated 100s if not 1000s. They must be more than that.
- 'Surprisingly, CD8+ T cells with identical T cell receptors exhibit wide variation in avidities, suggesting an additional level of regulation of T cell activity.' This indicates that we cannot predict a priori which T cells are most protective against tumors. #immunology
- a must read for anyone who are into immunology. MHC-II neoantigens shape tumour immunity and response to immunotherapy | Nature nature.com/articles/s4158โฆ
- Finally, a true immunology-oriented paper about #COVID19 that provides some scientific answers beyond technical data collection. @VirusesImmunity Adaptive immune determinants of viral clearance and protection in mouse models of SARS-CoV-2 science.org/doi/10.1126/scโฆ
- 1/ Another rollercoaster of a paper on Foxp3+ Tregs, this time from Rudenskyโs lab. It took over two years to get published, and I wouldnโt be surprised if some well-placed "connections" helped push it through. #immunology #science #Foxp3 #Tregs nature.com/articles/s4159โฆ
- Very nice review about Foxp3+ Tregs. some highlights: "We also revisit some tenets, maintained by the echo chambers of Reviews" "that rest on uncertain foundations or are a subject of debate." #immunology #Foxp3 #Tregs nature.com/articles/s4157โฆ






