David Usharauli (@3DiMMUNE) / X

David Usharauli

17.1K posts

David Usharauli

@3DiMMUNE

Immunologist & Biotech Co-Founder @Tregeutix on a mission to harness the power of Tregs & microbiota | Calling on visionary investors to join our journey 🚀

USA

Joined December 2014

David Usharauli
@3DiMMUNE
Dec 30, 2021
#omicron is spreading 2-5-times faster only among vaccinated and boosted population, but not among unvaccinated. Basically, omicron completely cancels out any effect vaccine+booster had on #deltavariant transmission among #vaccinated. #COVID19 medrxiv.org/content/10.110…
David Usharauli
@3DiMMUNE
Sep 8, 2021
When the hospitalization rate is 70% of the pre-vaccine period in a time when 85% of eligible people are fully vaccinated, people should look around and ask some tough questions. #COVID19 #vaccine #VE bloomberg.com/news/articles/… via @business
David Usharauli
@3DiMMUNE
Oct 21, 2021
The rate of loss of neutralizing Ab after the 3rd dose is even faster than after the 2nd dose (in NHPs). #mRNA #vaccine #boosterdose #COVID19 Protection against SARS-CoV-2 beta variant in mRNA-1273 vaccine–boosted nonhuman primates science.org/doi/10.1126/sc…
David Usharauli
@3DiMMUNE
Nov 12, 2021
"Our results suggest that once hospitalised the risk of death among #vaccinated and #unvaccinated patients in #Norway is similar." We still have no clear understanding of what determines #vaccine efficacy. Data are all over the place. #mRNA
medrxiv.org
Patient trajectories among hospitalised COVID-19 patients vaccinated with an mRNA vaccine in...
Objectives With most of the Norwegian population vaccinated against COVID-19, an increasing number and proportion of COVID-19 related hospitalisations are occurring among vaccinated patients. To...
David Usharauli
@3DiMMUNE
Mar 3, 2025
A Treg-centered model of self-nonself discrimination. 1/ A few days ago, Science published a major study on Foxp3+ Tregs. Here's my analysis & conceptual takedown of its implications. 🧵👇 #immunology #tolerance #Foxp3 #Tregs
science.org
Regulatory T cells constrain T cells of shared specificity to enforce tolerance during infection
During infections, CD4+ Foxp3+ regulatory T (Treg) cells must control autoreactive CD4+ conventional T (Tconv) cell responses against self-peptide antigens while permitting those against pathogen-d...
20K
David Usharauli
@3DiMMUNE
Mar 26, 2025
Genome-wide CRISPR screen in human T cells reveals regulators of FOXP3 Shimon Sakaguchi, et al. #immunology #Foxp3 #Tregs
Genome-wide CRISPR screen in human T cells reveals regulators of FOXP3
From nature.com
8.3K
David Usharauli
@3DiMMUNE
Jan 9, 2022
Prior #SARSCoV2 infection provides protection against both symptomatic and severe #DeltaVariant and #Omicron reinfections equivalent to 2-3 dose vax. It's time to acknowledge the equivalency of prior infection and 2-3 dose vaccination. #COVID19 medrxiv.org/content/10.110…
David Usharauli
@3DiMMUNE
Sep 8, 2020
Replying to @HelenBranswell
it is unlikely they put hold because one individual showed adverse reaction to vaccine when they may have already vaccinated 100s if not 1000s. They must be more than that.
David Usharauli
@3DiMMUNE
Jan 9, 2025
'Surprisingly, CD8+ T cells with identical T cell receptors exhibit wide variation in avidities, suggesting an additional level of regulation of T cell activity.' This indicates that we cannot predict a priori which T cells are most protective against tumors. #immunology
16K
David Usharauli
@3DiMMUNE
Oct 23, 2019
a must read for anyone who are into immunology. MHC-II neoantigens shape tumour immunity and response to immunotherapy | Nature nature.com/articles/s4158…
David Usharauli
@3DiMMUNE
Sep 2, 2021
Finally, a true immunology-oriented paper about #COVID19 that provides some scientific answers beyond technical data collection. @VirusesImmunity Adaptive immune determinants of viral clearance and protection in mouse models of SARS-CoV-2 science.org/doi/10.1126/sc…
David Usharauli
@3DiMMUNE
Feb 7, 2025
1/ Another rollercoaster of a paper on Foxp3+ Tregs, this time from Rudensky’s lab. It took over two years to get published, and I wouldn’t be surprised if some well-placed "connections" helped push it through. #immunology #science #Foxp3 #Tregs nature.com/articles/s4159…
19K
David Usharauli
@3DiMMUNE
Jul 19, 2023
Very nice review about Foxp3+ Tregs. some highlights: "We also revisit some tenets, maintained by the echo chambers of Reviews" "that rest on uncertain foundations or are a subject of debate." #immunology #Foxp3 #Tregs nature.com/articles/s4157…
10K
David Usharauli
@3DiMMUNE
Jul 15, 2021
this is very strange and scary. 1. The same number of new #COVID19 cases in both vaccinated/non-vaccinated groups [not good] 2. more hospitalization in vaccinated group only [really not good]. This is exactly opposite from what we supposed to observe if #vaccine worked.