NonsparseOncologist (@5

NonsparseOncologist

32.5K posts

NonsparseOncologist

@5_utr

Joined February 2021

Pinned
NonsparseOncologist
@5_utr
Dec 30, 2025
❣️I think this plot is at the top of the list for the most important plot of 2025. This notion of identifying and targeting with drugs sparse “drivers” of cancer is not consistent with actual pan-cancer gene expression multivariable analysis reality at all!
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NonsparseOncologist
@5_utr
Dec 23, 2024
Replying to @theliamnissan and @ksorbs
Dollar Store Thor looking rough
6.5K
NonsparseOncologist
@5_utr
Feb 11, 2024
Oh god another “data science influencer” claiming p-values are a measure of strength of the evidence against a null hypothesis, shoot me now 🙄
Matt Dancho (Business Science)
@mdancho84
Feb 10, 2024
Understanding P-Values is essential for improving regression models. In 2 minutes, learn what took me 2 years to figure out. 1. The p-value: A p-value, in statistics, is a measure used to assess the strength of the evidence against a null hypothesis. 2. Null Hypothesis (H0):
163K
NonsparseOncologist
@5_utr
Oct 16, 2025
Replying to @factpostnews
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NonsparseOncologist
@5_utr
Nov 26, 2024
‼️ EUROPA interim Ph3 RCT 70+ y/o low risk breast cancer -> BCS -> adjuvant endocrine only vs adjuvant APBI only APBI has better HRQoL than endocrine tx, adj mean difference 6.39 (0.14-12.65) 0 IBTR, LRR, or DM events!! 🤩 #SABCS24
32K
NonsparseOncologist
@5_utr
Dec 23, 2023
Replying to @JessicaTarlov and @MeidasTouch
Insane. George Carlin was right, they’re not pro-life, they’re ANTI-WOMAN
5.2K
NonsparseOncologist
@5_utr
Sep 26, 2023
Prophylactic RT Versus SOC for High-Risk Asymptomatic Bone Metastases Multicenter, Randomized Phase II Clinical Trial N=78, 122 high risk asymptomatic bone mets 1:1 SOC vs SOC + RT ⬇️ SRE ⬇️ admissions ⬆️ OS HR 0.49 (0.27 to 0.89) P = .018 🤩
ascopubs.org
Prophylactic Radiation Therapy Versus Standard of Care for Patients With High-Risk Asymptomatic...
In a multicenter RCT (n = 78), radiation to high-risk asymptomatic bone metastases ⬇ skeletal-related events and prolonged OS.PURPOSEExternal-beam radiation therapy (RT) is standard of care (SOC) for...
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NonsparseOncologist
@5_utr
Jan 22, 2025
❗️ Phase 2 FLOT x 3 -> PET -> 41.4 Gy + carbo/taxol -> surgery -> adjuvant nivo for non-pCR Interim: 2-yr OS 73%
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NonsparseOncologist
@5_utr
May 30, 2024
Rarely have I seen an article miss the mark this badly 🤯 Misguided calls for more “real world” observational evidence should be replaced by calls for more efficient RCTs; patients and society deserve inference based on RCTs, nothing less
17K
NonsparseOncologist
@5_utr
Jun 20, 2022
TRENDY: RCT of TACE vs. SBRT for HCC 👉 HCC, Child-Pugh grade A, one to three tumors, cumulative diameter ≤ 6cm, and ≥ 18 years old. 2 year LC 2x better with SBRT 🤩 😮 #radonc h/t @loladelamata
NonsparseOncologist
@5_utr
Feb 1, 2025
Oncology drug exclusion principle: the more targeted the drug, the faster evolutionary escape makes failure a certainty; the less targeted are bounded by nonspecific cytotoxic chemo, which faces less escape, but cure is limited by exposure to rest of the body to high deg toxicity
15K
NonsparseOncologist
@5_utr
Sep 29, 2024
FASTRACK II 100% LC and 100% CSS An excellent option for many patients with RCC
7.5K
NonsparseOncologist
@5_utr
Sep 9, 2023
‼️ Whole Breast Irradiation in Comparison to Endocrine Therapy in Early Stage Breast Cancer-A Direct and Network Meta-Analysis of Published Randomized Trials Local recurrence in BCS + WBI vs. BCS + ET group (HR = 0.62; CI-95%: 0.42-0.92; p = 0.019) 1/n
Whole Breast Irradiation in Comparison to Endocrine Therapy in Early Stage Breast Cancer-A Direct...
From pubmed.ncbi.nlm.nih.gov
17K
NonsparseOncologist
@5_utr
Sep 24, 2023
❗️ SBRT vs conventional palliative RT for bone Mets, meta-analysis of RCTs SBRT associated with >3 odds of being pain free at 3 months and 6 months 🤩 NCCN guidelines need to be revised to reflect this #radonc
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