Gregg W. Stone MD (@GreggWStone) / X

Gregg W. Stone MD

5,322 posts

Gregg W. Stone MD

@GreggWStone

Interventional cardiologist, trialist, innovator, educator, husband, father, loyal friend

New York and the world

Joined December 2016

Gregg W. Stone MD
@GreggWStone
Feb 27, 2025
2025 US guidelines for the management of ACS (STEMI and NSTE-ACS) just released. Insertion of a microaxial flow pump (Impella) to prevent death in in cardiogenic shock has received a class IIa LOE B-R recommendation. IABP and VA-ECMO are class III for rourine use.
70K
Gregg W. Stone MD
@GreggWStone
Sep 24, 2022
Our perspective on the vulnerable plaque and vulnerable patient just published in Nature Reviews Cardiology. Please DM me a request with your email address and I would be pleased to send you a journal-approved copy.
Gregg W. Stone MD
@GreggWStone
Mar 2, 2020
Published today in EHJ: Meta-analysis of all left main DES vs. CABG RCTs. 5 trials, 4612 pts, mean 5.6 year follow-up (including all long-term data from EXCEL, NOBLE and SYNTAX). Similar all-cause rates of death with PCI and CABG - RR 1.03, 95% CI 0.81–1.32; P = 0.78.
Gregg W. Stone MD
@GreggWStone
Dec 13, 2019
#EXCEL investigators detailed response to the false narrative that has been promulgated. tctmd.com/slide/official… Please read and move beyond sensationalism, back to science and patient care. Note: We will not further debate this in the press or on Twitter.
tctmd.com
Official Response from EXCEL Leadership
Gregg W. Stone MD
@GreggWStone
Mar 14, 2019
MitraClip approved by FDA today for Rx of severe secondary MR in pts with heart failure who remain symptomatic despite GDMT. Great day for suffering pts in whom this therapy offers potential for improved survival, reduced hospitalizations and enhanced quality-of-life.
Gregg W. Stone MD
@GreggWStone
Aug 28, 2021
MASTER DAPT trial. Important because this is the first trial in a high bleeding risk population adequately sized to convincingly demonstrate non-inferiority for ischemia. The new standard of care.
Gregg W. Stone MD
@GreggWStone
Dec 25, 2019
ISCHEMIA cost $100M of taxpayer money. Some are complaining that’s outrageous. Is it? There are 140,000,000 US taxpayers. ISCHEMIA took 7 years. That’s 10 cents per taxpayer per year. Worth it? I think so!! We should fund more major trials like this addressing essential issues.
Gregg W. Stone MD
@GreggWStone
Feb 27, 2025
NEW! 2025 US guidelines for the management of ACS (STEMI and NSTE-ACS) just released. Intravascular imaging guidance with OCT or IVUS during PCI in ACS is now recommended for left main or complex lesions with a class IA recommendation.
27K
Gregg W. Stone MD
@GreggWStone
Apr 18, 2020
At the Mount Sinai Hospital system, we’ve been running ~2000 COVID-19 in-pts per day, with ~500 in ICUs. Finally starting to see a downturn in these numbers. More than 2800 patients have been discharged. Amazing effort by everyone on the front line as well as hospital leadership.
Prof. Dr. Benhur Lee, MD 🦠🧬🔬
@VirusWhisperer
Apr 17, 2020
#COVID19 #COVID19nyc 3 days make a trend? After the incredible bravery & sacrifices of @MountSinaiNYC staff, we finally see 3 consecutive days of fewer #Covid_19 cases @MountSinaiNYC. Lockdowns work. @IcahnMountSinai
Gregg W. Stone MD
@GreggWStone
Mar 17, 2019
Both PARTNER 3 and EVOLUT low risk trials show reduced composite death/stroke/rehosp in low risk AS pts. Much faster recovery and early QOL. Some diffs between the trials in PPM, PV leaks, valve hemodynamics, but results both overwhelmingly positive. A new era has begun.
Gregg W. Stone MD
@GreggWStone
May 2, 2019
FDA has approved the pivotal randomized trial of Impella in 668 pts with anterior STEMI designed to demonstrate that LV unloading starting pre-PCI will safely reduce Infarct size. Hugely important study.
Gregg W. Stone MD
@GreggWStone
Aug 18, 2020
IVUS used in only 5.6% of nearly 2 million Medicare PCI pts - but strongly associated with reduced death, MI and reintervention (JACC CV Int publ today). Similar results to 10 RCTs. So why isn't IVUS (or OCT) used more frequently? Poll to follow.
Gregg W. Stone MD
@GreggWStone
Mar 12, 2020
Amazing case in JACC Int of a 58 yo asymptomatic man who developed a STEMI from plaque rupture 2 hrs after a routine CT with 0 calcium. It's the plaque morphology and inflammation, not the calcium that predicts risk! Calcium is a marker useful in some but (obviously) not all pts.
Gregg W. Stone MD
@GreggWStone
May 7, 2020
The EXCEL, NOBLE, SYNTAX and PRECOMBAT investigators have agreed to pool the data from their trials for an independently led individual patient data pooled analysis. Hopefully the data analysis will be completed and reported later this year.