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John Kastelein
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John Kastelein
@JohnKastelein
Professor of Medicine , Lipidologist , Trialist in Cardiometabolic Medicine , Entrepreneur in Biotech , Amsterdam , the Netherlands Husband and Father
Joined September 2021
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    John Kastelein
    @JohnKastelein
    Jun 26, 2023
    Replying to @drpablocorral @RFRedberg and 3 others
    I doubt statin therapy has cost trillions , after they became generic their costs were reduced to cents … but , more importantly living longer is not the issue , living the last two decades of your life without heart disease should be the prime motivation in my opinion
    49K
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    John Kastelein
    @JohnKastelein
    Mar 20, 2024
    sdLDL particles are more likely to get trapped in the arterial wall, leading to atherosclerosis. In @NewAmsPharma's ROSE2 clinical trial, patients receiving a combination of obicetrapib & ezetimibe achieved a >95% median reduction in small LDL-P levels. bit.ly/4coT5tt
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    5.8K
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    John Kastelein
    @JohnKastelein
    Aug 25, 2023
    Prof Erin Michos delivering her keynote on CETP inhibition at ESC
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    4.5K
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    John Kastelein
    @JohnKastelein
    Jun 18, 2023
    Replying to @BudoffMd
    He Matt , why would any physician on earth take a 66 year old man off his statin because he has a negative nuclear ?? Makes really no sense at all , even without the results of the nuclear …
    6.6K
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    John Kastelein
    @JohnKastelein
    May 29, 2024
    Could this be part of the explanation as to why FH patients can have a different clinical course wile rxposed to the same LDL-C levels ?
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    22K
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    John Kastelein
    @JohnKastelein
    May 28, 2024
    #EAS congress2024 ; sharing a table with our fabulous President , Prof Kosh Ray !
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    1.3K
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    John Kastelein
    @JohnKastelein
    Sep 17, 2022
    Nothing as important as constructing a family tree and find new patients that can be treated in the best possible way 😊. We showed this for the first time in 2001 in Lancet and now in 2022 the ticker indicates at least 35.000 heFH patients 🇳🇱
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    John Kastelein
    @JohnKastelein
    Oct 2, 2022
    This is my daily routine , my home gym in the old horse stable that came with this 1917 home ..💪
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    John Kastelein
    @JohnKastelein
    Mar 5, 2024
    I'd argue that LDL-C is a quality-of-life metric given its impact on cardiovascular risk--whether it's formally recognized or not. Well said, @CBallantyneMD.
    user avatar
    NewAmsterdam Pharma Corporation
    @NewAmsPharma
    Mar 5, 2024
    @JACCJournals Advances reports only ~30% of Medicare beneficiaries had their LDL-C measured within 90 days of treatment for a heart attack. @CBallantyneMD shares how reinstating LDL-C as a quality metric could not only reduce CVD burden but also help reduce healthcare inequities.
    3.4K
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    John Kastelein
    @JohnKastelein
    Sep 15, 2022
    Replying to @Drlipid
    There is only one true causal risk factor for ASCVD ; an apoB containing lipoprotein … all the rest are permissive or bystanders but never conditional ….that does not detract from the fact we combat the latter without mercy , but it helps to understand where to strike first 🤛
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    John Kastelein
    @JohnKastelein
    Dec 4, 2023
    Replying to @NewAmsPharma and @WUSTLmed
    More and more evidence is emerging that accumulation of cholesterol and its esters in brain cells are an early phenomenon of apoE4 carriers , the most important risk factor for Alzheimer’s … so , toxic sterols>inflammation> neurodegeneration is a pathway we now can research
    1.3K
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    John Kastelein
    @JohnKastelein
    Apr 7, 2024
    In @NewAmsPharma's ROSE2 trial, we observed a median 63.4% reduction in LDL-C among participants taking a combination of our #CETP inhibitor, obicetrapib, and ezetimibe. Our Phase 3 TANDEM study will examine the two in a fixed-dose combination.
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    John Kastelein
    @JohnKastelein
    May 10, 2024
    As with all medical matters, you’re your own best advocate. If it’s been a while since your last lipid panel, ask your doctor if it’s time to check your levels. Lower LDL-C for longer is better. #NationalLipidDay
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    NewAmsterdam Pharma Corporation
    @NewAmsPharma
    May 10, 2024
    Healthy adults should have their cholesterol checked at least once every 5 years. This #NationalLipidDay, learn how to read your lipid panel with help from @foundationofnla: bit.ly/3JOG8fJ
    A report showing the results of a cholesterol test. Text reads: National Lipid Day, May 10
    1.7K
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    John Kastelein
    @JohnKastelein
    Jun 26, 2023
    Replying to @Drlipid
    I always say ; kids with heFH basically have no side-effects on statins ; they do not read inserts or anti-cholesterol books nor do they see misery on the internet ..,
    1.4K

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