Sam Tsimikas, MD (@Lpa

Sam Tsimikas, MD

4,722 posts

Sam Tsimikas, MD

@Lpa_Doc

Educational forum on Lp(a) and related areas. Professor UC San Diego.

San Diego, CA

Joined October 2016

Following

14.9K

Followers

Pinned
Sam Tsimikas, MD
@Lpa_Doc
Feb 26, 2022
For those interested in the Saturday Morning Lp(a) Class, the course is now linked to my bio and is open access. Big thanks to @TheBhupiThakur for organizing the twittorials. It is ~500 tweets in 24 classes. Syllabus enclosed. I wish to all the joy of learning.
Bhupi | HYROX & Running Coach
@TheBhupiThakur
Feb 25, 2022
All Sat morning classes by @Lpa_Doc is now linked to this updated thread. Enjoy
Sam Tsimikas, MD
@Lpa_Doc
Apr 5, 2025
Now that people are checking Lp(a), it is becoming more obvious and accepted. When we published our paper on this, we had a lot of negative reactions because it was not clear if this was clinically relevant or would make people stop taking statins. Bottom line is statins treat
Lala
@shimmer2372
Apr 4, 2025
Replying to @Lpa_Doc
Had a huge LPa increase when I doubled my Crestor to 40mg. Added repatha and lowered my Crestor to 20mg - my LPA dropped 300 points. Now trying 5mg Crestor (with repatha). Could statins affects on LPA be different for everyone? My Dr. has never seen statin affect LPA this much.
41K
Sam Tsimikas, MD
@Lpa_Doc
Nov 4, 2024
An large (n=26,658 participants) came out today from our group, led by @hsbhatia, showing the independence of Lp(a) and LDL-C in CVD risk, and that low LDL-C does not necessarily offset Lp(a)-mediated risk. We are anxiously waiting Lp(a) HORIZON results. @PeterWilleit
30K
Sam Tsimikas, MD
@Lpa_Doc
Aug 8, 2020
Replying to @Lpa_Doc
Today's topic will be "Lp(a) and the “real” LDL-C". If at least 1 person is interested in this I will continue it, if no interest, the show will be over. 6/6
Sam Tsimikas, MD
@Lpa_Doc
Jul 20, 2022
BIG news: Lp(a) HORIZON is fully recruited (8325 pts)- a 20 yr journey for so many people to get here. The "Lp(a) Hypothesis" gets tested: in pts with optimally treated risk factors, does ⏬⏬ Lp(a) lead to clinical benefit? Will know in 2.5 yrs. $IONS prn.to/3zd4v11
Sam Tsimikas, MD
@Lpa_Doc
Jan 15, 2024
Two new articles came out in @JACCJournals today: Each suggested Lp(a) is ~6x more atherogenic than LDL-C when evaluated per apoB. Vera Bittner and I provide commentary how to put this in clinical context with atherogenicity vs # of particles. jacc.org/doi/10.1016/j.…
20K
Sam Tsimikas, MD
@Lpa_Doc
Aug 9, 2025
The issue of statins and Lp(a) increases has raised quite a bit of discussion. I think its instructive to see the context how I and my colleagues @UCSDCardiology got interested in this issue as it has several interesting aspects, including what is taken as medical dogma, how
18K
Sam Tsimikas, MD
@Lpa_Doc
Nov 21, 2024
Yes-ncbi.nlm.nih.gov/pubmed/29147686
You’re unable to view this Post because this account owner limits who can view their Posts. Learn more
39K
Sam Tsimikas, MD
@Lpa_Doc
May 26, 2025
We have a new Lp(a) paper, led by @derlinge from PROSPECT 2 using IVUS/NIRS. It shows high Lp(a) associates most with vulnerable plaque characteristics, whereas LDL-C with plaque burden. Lp(a) was measured by our @UCSDCardiology assay, the only Lp(a) assay I am aware of that is
12K
Sam Tsimikas, MD
@Lpa_Doc
Apr 2, 2025
A BIG moment just dropped: The design of the Lp(a)HORIZON trial is now published. sciencedirect.com/science/articl… Brief summary: 1- 8,323 patients 2- median Lp(a) level of 108 mg/dL and 236 nmol/L - higher than likely anticipated 3- 79% of patients were ≥90 mg/dL - higher than
12K
Sam Tsimikas, MD
@Lpa_Doc
Apr 10, 2021
In trying to understand the purely carnivorous diet of the Inuit/Eskimo and Lp(a), I have moved on from Vil S onto a new book: remarkably, the reputable investigators claim Inuit in the wild in 1908 could eat up to 14 pounds!! of seal meat in 24 hr- there goes your diet.....
Sam Tsimikas, MD
@Lpa_Doc
Jan 24, 2025
This is an artificial system of dietary manipulation to get LDL-C very high at baseline. Does not apply to >99.99% of people. If you started with LDL-C of 150, the chances are 100% statin would win out. The general public should not assume eating oreos will lower your LDL-C. It
Nicholas Fabiano, MD
@NTFabiano
Jan 24, 2025
Daily Oreos lowered LDL cholesterol more than high-intensity statin therapy. 🧵1/12
38K
Sam Tsimikas, MD
@Lpa_Doc
Jul 18, 2024
Nice paper today in @JAMACardio led by @BenoitArsenault - higher Lp(a) predicts faster progression in AS. Clinical pearl: if you measure Lp(a) in your pts with pre-existing AS, you can predict who needs more close f/u and testing, and look very smart to your referring MDs!
11K
Sam Tsimikas, MD
@Lpa_Doc
Sep 2, 2019
New EU Lipid guidelines are out. Kudos to EU for recommending everyone get an Lp(a) level once: "A one-off measurement of Lp(a) may help to identify people with very high inherited Lp(a) levels who may have a substantial lifetime risk of cardiovascular disease,"