Log inSign up
Sam Tsimikas, MD
4,722 posts
Image
user avatar
Sam Tsimikas, MD
@Lpa_Doc
Educational forum on Lp(a) and related areas. Professor UC San Diego.
San Diego, CA
Joined October 2016
92
Following
14.9K
Followers
  • Pinned
    user avatar
    Sam Tsimikas, MD
    @Lpa_Doc
    Feb 26, 2022
    For those interested in the Saturday Morning Lp(a) Class, the course is now linked to my bio and is open access. Big thanks to @TheBhupiThakur for organizing the twittorials. It is ~500 tweets in 24 classes. Syllabus enclosed. I wish to all the joy of learning.
    Image
    user avatar
    Bhupi | HYROX & Running Coach
    @TheBhupiThakur
    Feb 25, 2022
    All Sat morning classes by @Lpa_Doc is now linked to this updated thread. Enjoy
  • user avatar
    Sam Tsimikas, MD
    @Lpa_Doc
    Apr 5, 2025
    Now that people are checking Lp(a), it is becoming more obvious and accepted. When we published our paper on this, we had a lot of negative reactions because it was not clear if this was clinically relevant or would make people stop taking statins. Bottom line is statins treat
    Image
    user avatar
    Lala
    @shimmer2372
    Apr 4, 2025
    Replying to @Lpa_Doc
    Had a huge LPa increase when I doubled my Crestor to 40mg. Added repatha and lowered my Crestor to 20mg - my LPA dropped 300 points. Now trying 5mg Crestor (with repatha). Could statins affects on LPA be different for everyone? My Dr. has never seen statin affect LPA this much.
    41K
  • user avatar
    Sam Tsimikas, MD
    @Lpa_Doc
    Nov 4, 2024
    An large (n=26,658 participants) came out today from our group, led by @hsbhatia, showing the independence of Lp(a) and LDL-C in CVD risk, and that low LDL-C does not necessarily offset Lp(a)-mediated risk. We are anxiously waiting Lp(a) HORIZON results. @PeterWilleit
    Image
    30K
  • user avatar
    Sam Tsimikas, MD
    @Lpa_Doc
    Aug 8, 2020
    Replying to @Lpa_Doc
    Today's topic will be "Lp(a) and the โ€œrealโ€ LDL-C". If at least 1 person is interested in this I will continue it, if no interest, the show will be over. 6/6
  • user avatar
    Sam Tsimikas, MD
    @Lpa_Doc
    Jul 20, 2022
    BIG news: Lp(a) HORIZON is fully recruited (8325 pts)- a 20 yr journey for so many people to get here. The "Lp(a) Hypothesis" gets tested: in pts with optimally treated risk factors, does โฌโฌ Lp(a) lead to clinical benefit? Will know in 2.5 yrs. $IONS prn.to/3zd4v11
  • user avatar
    Sam Tsimikas, MD
    @Lpa_Doc
    Jan 15, 2024
    Two new articles came out in @JACCJournals today: Each suggested Lp(a) is ~6x more atherogenic than LDL-C when evaluated per apoB. Vera Bittner and I provide commentary how to put this in clinical context with atherogenicity vs # of particles. jacc.org/doi/10.1016/j.โ€ฆ
    Image
    20K
  • user avatar
    Sam Tsimikas, MD
    @Lpa_Doc
    Aug 9, 2025
    The issue of statins and Lp(a) increases has raised quite a bit of discussion. I think its instructive to see the context how I and my colleagues @UCSDCardiology got interested in this issue as it has several interesting aspects, including what is taken as medical dogma, how
    Image
    18K
  • user avatar
    Sam Tsimikas, MD
    @Lpa_Doc
    Nov 21, 2024
    Yes-ncbi.nlm.nih.gov/pubmed/29147686
    Image
    Youโ€™re unable to view this Post because this account owner limits who can view their Posts. Learn more
    39K
  • user avatar
    Sam Tsimikas, MD
    @Lpa_Doc
    May 26, 2025
    We have a new Lp(a) paper, led by @derlinge from PROSPECT 2 using IVUS/NIRS. It shows high Lp(a) associates most with vulnerable plaque characteristics, whereas LDL-C with plaque burden. Lp(a) was measured by our @UCSDCardiology assay, the only Lp(a) assay I am aware of that is
    Image
    12K
  • user avatar
    Sam Tsimikas, MD
    @Lpa_Doc
    Apr 2, 2025
    A BIG moment just dropped: The design of the Lp(a)HORIZON trial is now published. sciencedirect.com/science/articlโ€ฆ Brief summary: 1- 8,323 patients 2- median Lp(a) level of 108 mg/dL and 236 nmol/L - higher than likely anticipated 3- 79% of patients were โ‰ฅ90 mg/dL - higher than
    Image
    12K
  • user avatar
    Sam Tsimikas, MD
    @Lpa_Doc
    Apr 10, 2021
    In trying to understand the purely carnivorous diet of the Inuit/Eskimo and Lp(a), I have moved on from Vil S onto a new book: remarkably, the reputable investigators claim Inuit in the wild in 1908 could eat up to 14 pounds!! of seal meat in 24 hr- there goes your diet.....
    Image
  • user avatar
    Sam Tsimikas, MD
    @Lpa_Doc
    Jan 24, 2025
    This is an artificial system of dietary manipulation to get LDL-C very high at baseline. Does not apply to >99.99% of people. If you started with LDL-C of 150, the chances are 100% statin would win out. The general public should not assume eating oreos will lower your LDL-C. It
    user avatar
    Nicholas Fabiano, MD
    @NTFabiano
    Jan 24, 2025
    Daily Oreos lowered LDL cholesterol more than high-intensity statin therapy. ๐Ÿงต1/12
    Image
    38K
  • user avatar
    Sam Tsimikas, MD
    @Lpa_Doc
    Jul 18, 2024
    Nice paper today in @JAMACardio led by @BenoitArsenault - higher Lp(a) predicts faster progression in AS. Clinical pearl: if you measure Lp(a) in your pts with pre-existing AS, you can predict who needs more close f/u and testing, and look very smart to your referring MDs!
    Image
    11K
  • user avatar
    Sam Tsimikas, MD
    @Lpa_Doc
    Sep 2, 2019
    New EU Lipid guidelines are out. Kudos to EU for recommending everyone get an Lp(a) level once: "A one-off measurement of Lp(a) may help to identify people with very high inherited Lp(a) levels who may have a substantial lifetime risk of cardiovascular disease,"

New to X?

Sign up now to get your own personalized timeline!

Create account

By signing up, you agree to the Terms of Service and Privacy Policy, including Cookie Use.

Terms of Service|Privacy Policy|Cookie Policy|Accessibility|Ads info|ยฉ 2026 X Corp.
Don't miss what's happening
People on X are the first to know.
Log inSign up
Advertisement
Advertisement