Profluent (@ProfluentBio) / X

Profluent

170 posts

Profluent

@ProfluentBio

Grounded in nature, authored by AI

Emeryville, CA

profluent.bio

Joined September 2022

Pinned
Profluent
@ProfluentBio
Nov 19, 2025
Today we’re announcing $106M in new funding led by Altimeter Capital and Bezos Expeditions. This brings our total to $150M to scale our frontier AI models which make biology programmable. Our frontier models have generated functional proteins (Nature Biotech, 2023), created the
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Profluent
@ProfluentBio
Jul 30, 2025
We’re excited to share new data published in @Nature detailing the impressive activity, specificity, and low immunogenicity of our AI-designed CRISPR-Cas proteins, including OpenCRISPR-1. The future of gene editing is here and we’re scaling our capabilities to tackle the
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Profluent
@ProfluentBio
Nov 13, 2025
Protein language models just got an upgrade. Meet Profluent-E1: a free, flexible, frontier protein sequence encoder. E1 is built with retrieval augmentation to learn from multiple sequences. Models trained over 4T tokens with only 150M-600M params, E1 is SOTA for zero-shot
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Profluent
@ProfluentBio
Apr 22, 2024
We are thrilled to announce the first ever successful precision editing of the human genome with a gene editor designed from scratch with AI. businesswire.com/news/home/2024…
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Profluent
@ProfluentBio
Apr 16, 2025
What if the same AI advancements that have transformed ChatGPT could be replicated in biology? Enter ProGen3, our latest foundation model suite for protein generation.
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Profluent
@ProfluentBio
Apr 30, 2024
Check out @EwenCallaway's article in @nature about how we’re using protein language design to create highly performant #CRISPR gene editors, and what this could mean for medical applications 👉
‘ChatGPT for CRISPR’ creates new gene-editing tools
From nature.com
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Profluent
@ProfluentBio
Mar 6, 2025
At Profluent, we’re turning new possibilities into reality, one protein at a time. Our foundation models push the frontier of protein design beyond the limitations of random discovery.
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Profluent
@ProfluentBio
Mar 21, 2024
We’re excited to announce $35M in additional funding led by @sparkcapital to bring the total raised to $44M from investors including @insightpartners, @airstreet, @aixventureshq, @convergencevc, and a syndicate of angel investors across AI & biotech. businesswire.com/news/home/2024…
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Profluent
@ProfluentBio
Jan 7, 2025
1/ Today we announced new research in the ability of AI models to precisely modulate protein-DNA interactions without iterative lab screening. 🧵
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Profluent
@ProfluentBio
Aug 5, 2024
Proteins don't operate in a vacuum. So we built #proseLM, a functional protein design model that layers additional biological context on sequence data to design proteins more successfully. Learn more: profluent.bio/blog/generatin…
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Profluent
@ProfluentBio
Apr 21, 2025
ICYMI: Our platform enables generation of unique Cas-like systems that are less than 1/2-1/3 the size of legacy Cas9 proteins, with demonstrated functionality in the wet lab. These molecules (and more) are ready for licensing. Find out more below 👇
GIF
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Profluent
@ProfluentBio
Sep 27, 2024
1/ Reagent drop 🎤 After debuting OpenCRISPR-1, the world’s first AI-created and open-source gene editor, we’re thrilled to share that the tools detailed in our bioRxiv preprint have been added to the AddGene repository. 🧬Access the plasmids here: addgene.org/browse/article…
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Profluent
@ProfluentBio
Apr 23, 2024
Our CEO @thisismadani spoke with @CadeMetz at @nytimes about our landmark achievement in editing the human genome, the launch of OpenCRISPR-1 and what its open-source release could mean for the future of #CRISPR medicines. Read the full piece👇
Generative A.I. Arrives in the Gene Editing World of CRISPR (Published 2024)
From nytimes.com
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Profluent
@ProfluentBio
Nov 13, 2025
Replying to @ProfluentBio
Oh, and one more thing, we are open sourcing E1 for free research and commercial use. We built it to tackle hard protein design problems at Profluent; so if it is useful for us, it will be useful for you. Paper: storage.googleapis.com/e1-paper-a26c3… Blog: profluent.bio/showcase/e1 Repo:
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