We’re excited to see our latest @Nature paper online today! In collaboration with the Clardy lab, we identify a lipid from the Akkermansia muciniphila cell membrane that functions in homeostatic immunity nature.com/articles/s4158… 1/3
Xavier Lab
562 posts
Xavier Lab
@TheXavierLab
Genes to functions. Microbiome in health & disease. Computational biology. Chemical biology. Innate & adaptive immunity. broadinstitute.org/xavier-lab
- Exciting collab with @Honda1Kenya’s lab, out today in @Nature: A set of microbial strains taken from a human faecal donor can decolonize multidrug-resistant Enterobacteriaceae in the gut, including species associated with #IBD. (1/3)
- New in @NatImmunol! We identify pH sensor GPR65 as a controller of tissue inflammation in vivo and reveal functions of the I231L #IBD risk variant in multiple immune cell populations using newly-generated knock-in mice. 1/3 nature.com/articles/s4159…
- Out now @ImmunityCP! Our comprehensive #singlecell atlas of >720k intestinal cells from #crohnsdisease patients uncovers transcriptional heterogeneity across tissues/inflammation states & identifies potential regulators of fibrosis. bit.ly/3Jp85M0 @MGH_RI @broadinstitute
- Out in @CellCellPress! We expand our understanding of maternal influences on the infant gut microbiome, with potentially profound implications for immune and neurodevelopment early in life @tvatanen @DamianPlichta @MoranYassour @MGH_RI @broadinstitute cell.com/cell/fulltext/…
- Check out our study in @NatureMicrobiol describing how oral microbe #Veillonella parvula switches its metabolism to utilize inflammatory nitrate & colonize the gut. nature.com/articles/s4156…
- New in @ImmunityCP, we investigate microbiome antigens that engage the immune system & discover a universally recognized Bacteroidales epitope, w/T cell responses shifting from tolerance to inflammation in IBD 👏.
- Excited to share our latest study uncovering gut microbes and microbial metabolites linked to cardiovascular health! We show that Oscillibacter is associated w/decreased cholesterol in human subjects & that these bacteria take up &metabolize cholesterol.
- ICYMI: Great study in @Nature from @DevlinLab and Jun Huh’s lab at @harvardmed identifying gut bacteria and enzymes that produce two anti-inflammatory bile acid metabolites, 3-oxoLCA and isoLCA. (1/3)
- 1/3 Thrilled to share exciting new work in @Nature by @TouficMayassi, @li_chenhao, Åsa Segerstolpe, et al. Spatial profiling of mouse intestine reveals a landscape robust to perturbations in homeostatic drivers & adaptable in a spatially-restricted manner bit.ly/48ZzJKc
- New in @nature, work with Kenya Honda’s lab identifying trypsin-degrading Paraprevotella strains that affect gut IgA levels and host pathogen sensitivity. go.nature.com/3AXnxsO
- Excited to share our latest @cellhostmicrobe study, led by @schirmer_lab & @mstrazar07, integrating #metagenomics, #metabolomics, & #culturomics to establish microbe-metabolite connections associated w/pediatric #UC disease severity bit.ly/3TWD6fr @MGH_RI @broadinstitute
- How does a single genetic variant impact multiple disease pathologies? Now online @PNASNews, we identify a link between Crohn’s disease (CD) risk allele SLC39A8 A391T & dietary Manganese to uncover a mechanism based on impaired intestinal barrier integrity pnas.org/content/early/…
- Celebrating the establishment of The Gene Lay Institute of Immunology and Inflammation of Brigham and Women’s Hospital, Massachusetts General Hospital, and Harvard Medical School with institute directors—Dr. Vijay Kuchroo, Dr. Arlene Sharpe, and Dr. Ramnik Xavier.
