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Vamsi Mootha
@VamsiMootha
physician-scientist studying mitochondria, oxygen, bioenergetics Tweets = my own
Cambridge, MA
mootha.med.harvard.edu/index.html
Joined July 2016
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    Vamsi Mootha
    @VamsiMootha
    Feb 12
    If you love the organelles that power life, come to @GordonConf Mito & Chloroplasts July 19-24, Maine. Please RT. This conference (rich tradition!) will span the evolution, metabolism, and synthetic biology of these organelles. Many oral/poster slots: tinyurl.com/5n6upfxr
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    Vamsi Mootha
    @VamsiMootha
    Apr 9, 2021
    Happy 40th birthday to the human mtDNA genome sequence, reported in this classic @Nature paper in 1981, by Fred Sanger and co-authors (listed alphabetically, including pioneers in computer biology). The 16,569 bp mtDNA sequence has aged so gracefully. nature.com/articles/29045…
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    Vamsi Mootha
    @VamsiMootha
    Jul 8, 2020
    Breakthrough for mtDNA biology: precise editing via a bacterial dsDNA deaminase engineered it to operate within mitochondria. Led by inter-microbial warfare expert Joseph Mougous @UW and DNA base editor-in-chief @davidrliu @broadinstitute @HHMINEWS disq.us/t/3q82a3w
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    Vamsi Mootha
    @VamsiMootha
    May 10, 2020
    Where would any of us be without our mtDNA? With special gratitude to all of the amazing moms out there. #HappyMothersDay
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    Vamsi Mootha
    @VamsiMootha
    Nov 11, 2020
    Introducing MitoCarta3.0, an updated inventory of mito proteins, now w/ MitoPathway annotations and sub-compartment localization, freely available at: tinyurl.com/y2q2vznz
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    Vamsi Mootha
    @VamsiMootha
    Oct 9, 2024
    Clearly, we’re now in the golden age of biology: physiology/medicine Nobel to tiny RNAs; physics Nobel to neural networks; chemistry Nobel to protein structure prediction.
    31K
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    Vamsi Mootha
    @VamsiMootha
    May 28, 2021
    Such good news for our country -- the senate unanimously confirms @eric_lander as the first ever cabinet-level science advisor. Congrats Eric, and congrats @POTUS for having the vision to elevate this position to cabinet level. Go science!
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    Vamsi Mootha
    @VamsiMootha
    Oct 13, 2022
    Today, we and ⁦⁦@ganetzky1⁩ report ⁦@NEJM⁩ a remarkable case of twin boys with euthyroid hyper-metabolism (low body weight despite high caloric intake), due to a de novo mutation in mito CV that uncouples respiration from ATP synthesis.
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    nejm.org
    Congenital Hypermetabolism and Uncoupled Oxidative Phosphorylation | NEJM
    We describe the case of identical twin boys who presented with low body weight despite excessive caloric intake. An evaluation of their fibroblasts showed elevated oxygen consumption and decreased ...
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    Vamsi Mootha
    @VamsiMootha
    Jul 17, 2021
    Fascinating paper showing that anti-oxidant vitamins (GSH, NAC) *accelerate* aging in worms, mechanistically by suppressing the endogenous anti-oxidant stress response. Reminder of the value of randomized trials even for agents we assume “do no harm”
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    Dietary thiols accelerate aging of C. elegans
    From nature.com
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    Vamsi Mootha
    @VamsiMootha
    Aug 10, 2023
    Feel very honored to receive this distinction - I’m so grateful to my many mentors and past and current lab members that have joined me on this quest to study mitochondria.
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    HHMI
    @hhmi_science
    Aug 10, 2023
    Congratulations to HHMI Investigator Vamsi Mootha (@VamsiMootha) of @HarvardMed and Navdeep Chandel of @NUFeinbergMed on being named recipients of the 2023 Lurie Prize in Biomedical Sciences by @FNIH_Org! fnih.org/news/the-fnih-…
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    Vamsi Mootha
    @VamsiMootha
    Nov 15, 2019
    Can two wrongs make a right? When it comes to mitochondrial dysfunction, the answer can be yes. See our new CRISPR compendium with @broadinstitute @ScottVafai @SchreiberStuart @JohnDoench. cell.com/cell/fulltext/…
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    Vamsi Mootha
    @VamsiMootha
    Sep 18, 2020
    These images are gorgeous, how can you NOT want to study mitochondria?!
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    Christoph Spahn
    @miCHRIScopy
    Sep 18, 2020
    Here's our contribution to the #mitoawarenessweek! #Superresolution imaging of cellular membranes (preferentially mitos) in U2OS cells using lipophilic dyes. Reveals #mitochondria morphology and #cristae. We hope that this is useful to study mitochondria in health and disease
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    Vamsi Mootha
    @VamsiMootha
    Aug 16, 2023
    Today we report @Nature a biobank-scale analysis of #mitonuclear interactions, showing how our nuclear genotype impacts mtDNA copy number and even heteroplasmy! Led by @rahulg603 collab w/ @bmneale @broadinstitute @MassGeneralNews @harvardmed @HHMINEWS disq.us/t/4ibyjjo
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    Vamsi Mootha
    @VamsiMootha
    Oct 10, 2022
    Delighted to introduce SNORCL, a genetic tool for on-demand generation of localized oxygen inside living cells. We harness the power of genetics to express a xporter (NIS) and enzyme (Cld) that together yield SupplemeNtal Oxygen Released from ChLorite. tinyurl.com/54wre8nx