Xiao Wang (@WangXiaoLab) / X

Xiao Wang

138 posts

Xiao Wang

@WangXiaoLab

Associate Professor at MIT Chemistry and Core Member at Broad Institute of MIT and Harvard

Boston

Joined June 2018

Pinned
Xiao Wang
@WangXiaoLab
Sep 23, 2024
Chapter 2 of branched RNA: chemically modified branched cap for multi-capped mRNA and capped circular RNA (QRNA)--the cellular translation machinery is surprisingly tolerant of unnatural structures! Beyond enhanced performance, the mechanism is intriguing: rdcu.be/dUQKX
Hongyu Chen
@HongyuChenChem
Sep 23, 2024
Synthesizing RNA can be as fun as LEGO puzzles! This work is co-led by my incredible colleagues @LDangliang and @AbhiAditham . Huge thanks to my supervisor @WangXiaoLab for such amazing ideas. We are also grateful for the editor, reviewers, and all collaborators along the way.
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Xiao Wang
@WangXiaoLab
Mar 22, 2024
Why can RNA only be linear or circular? It can be branched! We made multi-tailed mRNA, and we had fun! Here is our story led by brilliant graduate student @HongyuChenChem: rdcu.be/dB7ck and his cartoon illustration👇@ChemistryMIT @broadinstitute
Hongyu Chen
@HongyuChenChem
Mar 22, 2024
Thrilled to see our work on chemically and topologically engineered mRNA online! Using a chemo-enzymatic approach, we introduced multiple end-modified polyA tails on a single mRNA to boost its stability and translatability overtime. nature.com/articles/s4158…
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Xiao Wang
@WangXiaoLab
Jun 29, 2023
RIBOmap for spatially resolved single-cell translatomics is published today! Congrats to the whole team and thanks so much for the constructive feedback and great suggestion from the editor, reviewers, colleagues, and friends!
science.org
Spatially resolved single-cell translatomics at molecular resolution
RIBOmap enables single-cell in situ profiling of mRNA translation in 3D for thousands of genes in intact cells and tissues.
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Xiao Wang
@WangXiaoLab
Oct 2, 2022
Thrilled to share RIBOmap, a 3D in situ profiling method to detect mRNA translation for thousands of genes simultaneously in the context of subcellular architecture, cell types, and tissue anatomy led by @huzengHZ @jiahaoh511 @JingyiRen
biorxiv.org
Spatially Resolved Single-cell Translatomics at Molecular Resolution
The precise control of mRNA translation is a crucial step in post-transcriptional gene regulation of cellular physiology. However, it remains a major challenge to systematically study mRNA translat...
Xiao Wang
@WangXiaoLab
Jan 9, 2022
Excited to share our new work on next-gen mRNA therapeutics led by talented @AbhiAditham and @HailingShi. We developed mRNA-oligonucleotide conjugated RNA (mocRNA) to stabilize RNA and boost protein expression in mammalian cells.
MIT Chemistry
@ChemistryMIT
Jan 7, 2022
Researchers from @WangXiaoLab have developed next-gen mRNA therapeutics with higher stability and efficiency through ligation. Paper published today in ACS Chemical Biology. Congratulations! Read more here: chemistry.mit.edu/chemistry-news…
Chemically Modified mocRNAs for Highly Efficient Protein Expression in Mammalian Cells
From pubs.acs.org
Xiao Wang
@WangXiaoLab
Oct 2, 2022
Excited to share TEMPOmap, our new spatiotemporal transcriptomics method that integrates metabolic labeling with 3D in situ sequencing to simultaneously profile the age and location of individual RNA molecules led by @JingyiRen Haowen Zhou and @huzengHZ
biorxiv.org
Spatiotemporally resolved transcriptomics reveals subcellular RNA kinetic landscape
Spatiotemporal regulation of the cellular transcriptome is crucial for proper protein expression and cellular function[1][1]. However, the intricate subcellular dynamics of RNA synthesis, decay,...
Xiao Wang
@WangXiaoLab
Oct 2, 2022
Happy to share our spatial atlas of the mouse central nervous system at molecular resolution using STARmap PLUS method and ClusterMap (rdcu.be/cWLg4) pipeline led by @HailingShi, @yiyiyihe, @Yiming_Zhou_PhD in collaboration with @ganoopyliujia. biorxiv.org/content/10.110…
Xiao Wang
@WangXiaoLab
Sep 28, 2023
Huge congrats to Hailing and the whole team, and thanks so much for the suggestions and help from the editor, reviewers, and colleagues through the long journey! Spatial atlas of the mouse central nervous system at molecular resolution: rdcu.be/dnaYu
Hailing Shi
@HailingShi
Sep 27, 2023
Thrilled to see our work finally online! We utilized in situ spatial transcriptomic method STARmap PLUS to map 1.09 million cells in the adult mouse central nervous system at molecular resolution and identified previously unknown tissue architectures. nature.com/articles/s4158…
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Xiao Wang
@WangXiaoLab
Feb 4, 2023
Excited to share the collaboration with Prof. Morgan Sheng's lab and Genetech about using STARmap PLUS to dissect AD-associated gene programs and cell types with single-cell and spatial resolutions. Thanks to all the co-workers, editors, and reviewers! rdcu.be/c4SQr
Nature Neuroscience
@NatureNeuro
Feb 2, 2023
STARmap PLUS, combining high-res spatial transcriptomics with protein detection in the same tissue section, reveals a cellular map of disease progression in an #Alzheimer's mouse model New from @huzengHZ @jiahaoh511 @PixelDream_cn @WangXiaoLab et al. nature.com/articles/s4159…
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Xiao Wang
@WangXiaoLab
Sep 23, 2024
Happy to share CAST as the "BLAST" tool for spatial omics, searching and aligning similar patterns across datasets while revealing their differences with prototype demo of querying new data against reference spatial atlas and comparative spatial studies👇rdcu.be/dULBj
Shuchen Luo
@nemo08061
Sep 20, 2024
CAST enables physical alignment of spatial omics data across replicates, techs, modalities at single-cell resolution. Such accurate alignment enables spatial atlas searching, unbiased DEG identification, and reconstruction of spatial multi-omics. DM for questions and collabs!
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Xiao Wang
@WangXiaoLab
Apr 10, 2023
Congrats to @JingyiRen, @hzhou99, and the great team! With TEMPOmap, we can snapshot RNA life cycle from birth to death for thousands of genes with single-cell and subcellular resolutions, revealing that RNA kinetics, fast and slow, serves gene functions. nature.com/articles/s4159…
Rena Ren
@JingyiRen
Apr 10, 2023
Thrilled to share the publication of TEMPOmap in its final version! It has been a challenging and rewarding journey for the team. Our new method resolves spatiotemporal transcriptomics at subcellular resolution. Check it out if you are interested! nature.com/articles/s4159…
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Xiao Wang
@WangXiaoLab
Sep 28, 2023
Thanks so much! Our molecular tissue region analysis was greatly inspired by your earlier work and the concept of unsupervised (non-expert, data-driven), molecular redefinition of neuroanatomy
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Xiao Wang
@WangXiaoLab
May 25, 2019
Thank you very much! I'm really looking forward to joining the community in the fall!
Laura Kiessling
@ChemicalBiology
May 24, 2019
Fortunate to have the talented Xiao Wang joining ⁦@ChemistryMIT⁩ and ⁦@broadinstitute⁩ this fall. Looking forward to her studies imaging #RNA images.app.goo.gl/UoSUxBs3ngaZV9…
Xiao Wang
@WangXiaoLab
Jun 29, 2023
Replying to @WangXiaoLab
Thanks Dr. Rong Fan's perspectives on how RIBOmap and the profiling of whole RNA life cycle can serve in the context of spatial multi-omics to bridge the gap between (epi-)genotype to phenotype @RongFan8. BTW, the image illustration is just so cute science.org/doi/10.1126/sc…
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