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Cofactors are a crucial part of the gene activation process. Yet, we still don't have a comprehensive understanding of how and why they are used by different genes. Proud to present our attempt to address this key question, now published
Charlie Bell
406 posts
Charlie Bell
@charles_bell92
Post-doc in the Faulkner lab and Dawson lab alumni
ARC DECRA Fellow
Interested in how gene regulatory mechanisms contribute to biological complexity
Joined May 2016
- I am looking for a motivated PhD student who is interested in understanding the fundamentals of gene regulation. They will be working directly with me on a DECRA funded project (scholarship guaranteed for domestic students). DM me if you know of anyone interested, including you
- Proud to present my latest work with @MAF_Dawson investigating how transcription factors and core promoters influence the mechanisms of transcription biorxiv.org/content/10.110… Results described below 👇🧵
- two awesome papers out today in Nature designing synthetic cell-type specific enhancers - a major achievement, made possible through deep learning and use of massive ATAC-seq datasets. Expanding on the approach first pioneered in yeast in one of my favourite papers. Links below:
- Our review about non genetic resistance in cancer is now online. We set out to define the key variables and potential mechanisms that drive non genetic evolution.
- Super excited to announce I have been awarded the ARC-DECRA @arc_gov_au to explore how transcription factors activate gene expression. Thanks to all my amazing supervisors of the years - Andrew Perkins, @MAF_Dawson and @Faulkner_Lab #DECRA #DE25
- cell.com/molecular-cell… Transcriptional noise is just that. RIP pervasive functionality
- "Evolution is a progression of form and function, but it is not purposeful. The important lesson here is that only mathematics is the art of the perfect. Physics is the art of the optimal, but biology is the art of the satisfactory" RIP Sydney Brenner
- Redistribution of cofactors is finally being realised as a major component of cell type specific gene expression programs, and as a result a major component of cell date decisions
- so glad that our endless discussions about the nitty gritty of CRISPR screens resulted in this awesome paper - congrats @gilan_omer and everyone in @TheDawsonLab nature.com/articles/s4159…
- beautiful paper, looks even better in its final form science.org/doi/epdf/10.11…
- Replying to @charles_bell92Original approach in yeast - a must read
- Interesting structural observations about how the Mediator Kinase module is involved in Pol2 initiation and post initiation events. I have been trying to think about how this fits with the variable dependence of different TFs and genes on the kinase module...You’re unable to view this Post because this account owner limits who can view their Posts. Learn more
