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Dr. David Ludwig
@davidludwigmd
Endocrinologist, Nutrition Researcher, Public Health Advocate. #1 NYT bestselling author of Always Hungry? and cookbook Always Delicious.
Brookline, MA
drdavidludwig.com
Joined August 2014
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    Dr. David Ludwig
    @davidludwigmd
    May 1
    Are Trials of ULTRA-PROCESSED FOOD Reliable? “as good a clinical trial as you can get” “most important study ever done to explain weight gain” “worse than worthless” 👉These quotes by nutrition experts refer to the same study. Who's right? Open access tandfonline.com/doi/full/10.10…
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    Dr. David Ludwig
    @davidludwigmd
    Nov 14, 2018
    Are all calories alike to the body? Our new feeding study – among the largest ever done – suggests not. A low-carbohydrate diet sped up metabolism by ≈ 250 calories a day. This effect could help weight loss maintenance. Free access to study linked here:
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    The Case for a Low-Carb Diet Is Stronger Than Ever
    From elemental.medium.com
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    Dr. David Ludwig
    @davidludwigmd
    Jan 4, 2021
    Insulin was discovered in 1921. Previously, a low-carb diet was the mainstay of treatment for all types of diabetes. Afterwards, high-carb diets became popular, but not because of evidence of superiority 👉Time to rediscover centuries-old wisdom on diet jci.org/articles/view/…
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    Dr. David Ludwig
    @davidludwigmd
    Dec 11, 2019
    Said about a ketogenic diet: 1979: Such high fat intake will make you fat 1999: You might not get fat but you'll get heart disease 2019: You might not get heart disease, but it has severe side-effects 👉My new review of the science (full free access): academic.oup.com/jn/advance-art…
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    Dr. David Ludwig
    @davidludwigmd
    Nov 7, 2019
    Nearing the 100th anniversary of insulin's discovery: 👉Original rights sold for $1. "Insulin...belongs to the world" 👉Yet Americans pay $100s/mo for this lifesaving drug 👉$300 insulin in US costs $20 in Canada @NEJM calls for solution to this crisis
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    nejm.org
    The U.S. Insulin Crisis — Rationing a Lifesaving Medication Discovered in the 1920s | NEJM
    The members of the team that discovered insulin sold the patent to the University of Toronto for $1 each because they felt that the drug belonged to the public. Nearly 100 years later, insulin is i...
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    Dr. David Ludwig
    @davidludwigmd
    Dec 18, 2018
    In a major new review, traditional hunter-gatherers seen free of obesity/diabetes, even though many lived to old-age. EXPLANATION? >Not calorie expenditure >Not meat vs plants >Not fat vs carbs 👉No processed, fast-digesting carbs (except honey)
    Members of the Hadza tribe in Tanzania on a zebra hunt.
    Is There an Optimal Diet for Humans? (Published 2018)
    From nytimes.com
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    Dr. David Ludwig
    @davidludwigmd
    Dec 29, 2018
    Are all calories alike to the body? Or are fast-digesting carbs including refined grains and sugar uniquely fattening? Our review of the Carbohydrate-Insulin Model of obesity selected Top Article of 2018 in @JAMAInternalMed. Full free access available here jamanetwork.com/journals/jamai…
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    Dr. David Ludwig
    @davidludwigmd
    Jan 2, 2018
    A new genetic study from our Boston team supports a key tenet of the Carbohydrate-Insulin Model. High insulin secretion throughout life predicts weight gain, not the other way around. See my nontechnical summary with links to the full article and editorial medium.com/@davidludwigmd…
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    Dr. David Ludwig
    @davidludwigmd
    Apr 14, 2021
    How do carbs affect the brain? In one of the biggest feeding studies of this Q, a low-carb (20% cals) diet ⬇️ brain activity in: 👉 Nucleus accumbens ("addiction center") 👉 Hypothalamus (controls hunger & metabolism) 👉 Effects related to ins secretion academic.oup.com/jn/advance-art…
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    Dr. David Ludwig
    @davidludwigmd
    Feb 17, 2022
    A meta-analysis found that high carb diets slow metabolism: pubmed.ncbi.nlm.nih.gov/33274750/ How might this happen? 👉In a new study, mitochondrial respiration in fat tissue was suppressed on a 60% carb diet (vs 20 or 40% carb) Findings preliminary. Open access:nature.com/articles/s4143…
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    Do Lower-Carbohydrate Diets Increase Total Energy Expenditure? An Updated and Reanalyzed Meta-Ana...
    From pubmed.ncbi.nlm.nih.gov
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    Dr. David Ludwig
    @davidludwigmd
    Mar 9, 2018
    In preparation for gastric bypass, a 4-week ketogenic diet produced "highly significant" decreases in: > Body fat (15-18%) > Glucose > LDL cholesterol > Triglycerides > Liver size Diet had high acceptability SO WHY NOT STAY ON THE DIET AND SKIP THE BYPASS? link.springer.com/epdf/10.1007/s…
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    Dr. David Ludwig
    @davidludwigmd
    Jun 8, 2019
    Intermittent fasting for type 1 diabetes? Goes against everything I was taught to teach my patients. But this approach, and low carb diets, hold promise for a new era of diabetes control (types 1 & 2). NEEDED: clinical trials of novel diets, not just drugs
     
    Intermittent Fasting Made My Life Easier, and Happier (Published 2019)
    From nytimes.com
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    Dr. David Ludwig
    @davidludwigmd
    Sep 13, 2021
    To paraphrase Mark Twain: Reports of the death of the Carbohydrate-Insulin Model have been exaggerated. 👉17-author review @AJCNutrition 👉Deep dive on obesity mechanisms 👉Numerous hypotheses to guide constructive debate Free text👉 doi.org/10.1093/ajcn/n… Thread (0/12)👇
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    Dr. David Ludwig
    @davidludwigmd
    Mar 2, 2019
    Breakfast in the classroom INCREASED obesity rates among grade school children. Perhaps the problem isn't breakfast, but the poor quality (processed carbs) typical of school food? 👉"intervention schools ... offered only cold items (eg, cereal, muffins)."
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    Effect of Breakfast in the Classroom on Childhood Obesity
    From jamanetwork.com