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Debora Marks
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Debora Marks
@deboramarks
Mission: design of biological interventions for environment and human health (to save the world)
boston
marks.hms.harvard.edu
Joined September 2008
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    Debora Marks
    @deboramarks
    Mar 23
    Meet evedesign: a new open-source ML framework that makes protein design accessible and interoperable. 📢 See our post: deboramarkslab.substack.com/p/evedesign-bi… Protein design models are powerful, but combining them shouldn’t require custom glue code. ✅Combine models for multi-objective
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    16K
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    Debora Marks
    @deboramarks
    Apr 27, 2021
    Our new paper uses WaveNet-type method for “Protein Design and Variant Prediction” no alignments needed ! trains on only natural sequences with a generative autoregressive model on a dilated-CNN - collab with McMahon, Kruse and @AashishManglik nature.com/articles/s4146… 1/7
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    Debora Marks
    @deboramarks
    Oct 27, 2021
    Fab collaboration with @OATML_Oxford - our paper out today
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    Disease variant prediction with deep generative models of evolutionary data
    From nature.com
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    Debora Marks
    @deboramarks
    Aug 4, 2020
    Do we need new ways to analyze biological sequences? Will it make a difference? Yes -
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    biorxiv.org
    Generative probabilistic biological sequence models that account for mutational variability
    Large-scale sequencing has revealed extraordinary diversity among biological sequences, produced over the course of evolution and within the lifetime of individual organisms. Existing methods for...
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    Debora Marks
    @deboramarks
    Jul 29, 2022
    Following the 200 million structures from #AlphaFold today - the Marks lab *may* release 200 BILLION structures of sequences only one mutation away from natural proteins
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    Debora Marks
    @deboramarks
    Nov 30, 2021
    Did you know you can publish in Nature before you even submit the paper?
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    Debora Marks
    @deboramarks
    Aug 14, 2020
    Very proud LMRL lmrl.org was accepted for a second year at NeurIPS neurips.cc. Can ML accelerate biomedical discovery? From medicines for people, to protein designs that eat plastics, to forecasting viral evolution, to human genetic variation. Come!
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    Debora Marks
    @deboramarks
    Oct 6, 2020
    Great to be awarded a NIH Director's Transformative Research Award with amazing team @chang_c_liu and Andrew Kruse commonfund.nih.gov/TRA/recipients
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    Debora Marks
    @deboramarks
    Feb 16, 2024
    How can we use #GenerativeAI for #ProteinDesign? - check out work from our labs @deboramarks and @yaringal
    nature.com
    Machine learning for functional protein design
    Nature Biotechnology - Notin, Rollins and colleagues discuss advances in computational protein design with a focus on redesign of existing proteins.
    9.7K
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    Debora Marks
    @deboramarks
    Aug 18, 2021
    Machine learning for synthetic immunology ..and new antimicrobial discovery : hiring !
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    deboramarkslab.com
    Debbie Marks Lab
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    Debora Marks
    @deboramarks
    Oct 10, 2024
    Replying to @ATinyGreenCell
    I suppose my lab deboramarkslab.com - ha ha Might also look back at our protein structure from sequence too - umm 2011?
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    deboramarkslab.com
    Debbie Marks Lab
    19K
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    Debora Marks
    @deboramarks
    Jun 16, 2020
    NEW #SARS_CoV_2 resource from Marks & Sander labs! What effects will mutations have? How are SARS-CoV-2 proteins folded? What interactions are important? We're using ML to help accelerate #COVID research/therapies. Our results so far are LIVE at marks.hms.harvard.edu/sars-cov-2/
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    Debora Marks
    @deboramarks
    Mar 30, 2021
    Woohoo - Postdoc positions in the new Schmidt Center @ the Broad - in ML and biomedicine - choose any lab; come work in mine! broadinstitute.wd1.myworkdayjobs.com/en-US/broad_in
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    Debora Marks
    @deboramarks
    Jun 17, 2020
    Will this turn the gene regulation world around ? Great work by Barkai lab cell.com/molecular-cell…

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