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LipoFan
@lipo_fan
EAS Member Just a mechanical engineer with expertise in piping, with a passion for lipids The selection of any quote is always biased. Please, read the papers
Joined January 2022
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    LipoFan
    @lipo_fan
    Aug 25, 2025
    Why does this happen in the KETO-CTA study? Is it inexplicable❓ The claim repeated by many critics about lack of contraste of exposure seems clearly incorrect, but then why❓ The science is not settled..., do the current new data add value to the debate❓ MY THOUGHTS
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    LipoFan
    @lipo_fan
    Jul 14, 2023
    "Atherosclerosis regressed in patients with the greatest reduction in CRP levels, but not in those with the greatest reduction in LDL cholesterol levels".
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    LipoFan
    @lipo_fan
    Mar 22, 2025
    🥴"LDL but not statins is the direct cause of intracerebral hemorrhage" 😞"Statins raise intracerebral hemorrhage risk mainly through their LDL-C-lowering effects" ✍️"414,253 participants, during a median follow-up of 14.01 years, drug-target Mendelian Randomization analysis"
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    LipoFan
    @lipo_fan
    Nov 5, 2024
    ☹️"We describe two patients with elevated Lp(a) who despite having reduction of CORRECTED LDL TO ZERO presented with ACS. 👀In our cases, RAPID DISEASE PROGRESSION may be explained by residual elevated LP(A) AND POSSIBLE INFLAMMATION"
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    LipoFan
    @lipo_fan
    Nov 24, 2023
    "We estimate that the atherogenicity of LP(A) IS AROUND 6-FOLD GREATER THAN THAT OF LDL ON A PER PARTICLE BASIS. We conclude that the atherogenicity of Lp(a) (per unit increase in particle number) is substantially greater than that of LDL"
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    LipoFan
    @lipo_fan
    Feb 2, 2025
    💚"Our understanding of ASCVD has evolved beyond the SIMPLISTIC NOTION OF LIPID ACCUMULATION, embracing the intricate interplay of DYSREGULATED cellular METABOLISM" ❤️"Before the appearance of foam cells and the formation of fatty streaks, disturbed FSS drives EC activation"
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    LipoFan
    @lipo_fan
    Sep 29, 2023
    "In the present study, we found that the amount of LDL-C lowering does not predict the clinical outcomes of ASCVD. The BENEFITS of ASCVD risk REDUCTION after statin therapy MAY NOT RELATED to LDL-C LOWERING or LDL-C goal based treatment"
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    LipoFan
    @lipo_fan
    Nov 15, 2024
    👀"HYPERCHOLESTEROLEMIA (mostly LDLC) WITHOUT INSULIN RESISTANCE, visceral obesity or other dyslipidemia-related changes 😎Interestingly,NO ATHEROSCLEROTIC PLAQUES developed 😏In vivo evidence fatty streaks do not advance to plaque formation in the absence of insulin resitance"
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    LipoFan
    @lipo_fan
    Sep 5, 2023
    "We conclude that acute starvation in healthy, nonobese human subjects increases serum total cholesterol, LDL cholesterol and apo B concentrations"
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    LipoFan
    @lipo_fan
    Oct 27, 2023
    Essential knowledge: 1️⃣Prolonged exposure to supranormal arterial pressure of strenuous exercise ➡️mechanical damage 2️⃣Evidence STRONGLY SUPPORTS that atherosclerosis begins with ENDOTHELIAL DAMAGE 3️⃣Conditions of hyperlipidemia, ENDOTHELIAL DYSFUNCTION induces transcytosis
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    LipoFan
    @lipo_fan
    Nov 18, 2022
    "Plaque burden, not stenosis per se, is the main predictor of risk for CVD events and death. Thus, patients with a comparable calcified atherosclerosis burden generally carry a similar risk for CVD events regardless of whether they have nonobstructive or obstructive CAD."
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    LipoFan
    @lipo_fan
    Sep 9, 2023
    "PCSK9 is a risk factor for adverse cardiovascular events in AF patients independent of their lipid profile. PCSK9-mediated platelet activation might represent a novel mechanism responsible for the increased cardiovascular risk in this population"
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    LipoFan
    @lipo_fan
    Oct 16, 2022
    If you find people who are sincerely re-evaluating their opinion, you have a treasure close by. Usually you only see people who just want to reassert themselves. Ego rules
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    LipoFan
    @lipo_fan
    Nov 25, 2023
    ARE REMNANTS MORE ATHEROGENIC THAN LDLS? 🟢 TRL/remnant-C was a STRONG predictor of CHD RISK INDEPENDENT of apoB and LDL-C. ➡️ Results support remnants being more atherogenic 🤔 How much more atherogenic?
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