Mikhail Shapiro (same on bsky) (@mikhailshapiro) / X

Mikhail Shapiro (same on bsky)

1,264 posts

Mikhail Shapiro (same on bsky)

@mikhailshapiro

Bio-Acousto-Magneto-Neuro-Chemical Engineer Max Delbrück Professor @Caltech Investigator @HHMI_science Co-founder @Merge Labs Opinions are my own.

Pasadena, CA

shapirolab.caltech.edu

Joined June 2009

Mikhail Shapiro (same on bsky)
@mikhailshapiro
Jul 13, 2020
24 yrs ago, Roger Tsien et al introduced the first fluorescent biosensors based on #GFP. Today, we introduce the first acoustic biosensors based on #gasvesicles. Now it's possible to image the action of specific molecules (enzymes) in the body w/ultrasound nature.com/articles/s4158…
After 5 years, my @Caltech colleagues finally realized that I am unhelpful, and voted to drop the word "Assistant" from my title! ;-). Honored to be part of this amazing group of faculty, students and staff. #tenure #Caltech4ever
Mikhail Shapiro (same on bsky)
@mikhailshapiro
Sep 23, 2021
Thank you @HHMINEWS for supporting our lab! Amazing honor to join the HHMI family alongside researchers I deeply admire. Thanks to everyone in our lab @Caltech who made this possible and is working hard to build the future of biomolecular ultrasound.
Mikhail Shapiro Named HHMI Investigator
From caltech.edu
Mikhail Shapiro (same on bsky)
@mikhailshapiro
Sep 27, 2021
Can cells be engineered to infiltrate a tumor and blow it up from the inside? Yes, when they express #gasvesicles as seeds for ultrasound-triggered bubble cavitation! Congrats to star postdoc @bar_zion and team on this publication!
Acoustically triggered mechanotherapy using genetically encoded gas vesicles
From nature.com
Mikhail Shapiro (same on bsky)
@mikhailshapiro
Sep 27, 2024
Can we map gut inflammation with ultrasound? Yes, using probiotic biosensors! 🔊 Imagine drinking a "diagnostic yogurt" and getting an ultrasound instead of endoscopy or colonoscopy 😁. Congrats to @MarjorieBuss and collaborators on this advance. doi.org/10.1101/2024.0…
GIF
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Mikhail Shapiro (same on bsky)
@mikhailshapiro
Nov 7, 2024
Can we make Acoustic Proteins with different "colors" the way the developers of GFP made BFP, YFP, etc?🌈 Yes, via #directedevolution of #gasvesicles! Congrats to @nivinnystrom et al on the first GVs multiplexed based on nonlinear response to ultrasound. biorxiv.org/content/10.110…
57K
Mikhail Shapiro (same on bsky)
@mikhailshapiro
Jan 25, 2022
How do cortical neurons respond to focused ultrasound? By opening mechanosensitive ion channels, accumulating Ca2+ and spiking. Congrats to Sangjin Yoo and colleagues @Caltech on the official publication of this detailed biophysical study. nature.com/articles/s4146…
Can ultrasound detect gene expression in single cells? Yes, with a new ultrasensitive imaging method called BURST and acoustic reporter genes based on #gasvesicles. Congrats to @dannypsawyer & team, who describe this approach in today's @naturemethods. nature.com/articles/s4159…
Mikhail Shapiro (same on bsky)
@mikhailshapiro
Mar 22, 2021
Is there a happy medium between @neuralink’s invasive electrodes and @kernelco’s low resolution? Yes! Thrilled to share the first step toward minimally invasive ultrasonic brain-machine interfaces, out today in @NeuroCellPress. cell.com/neuron/fulltex…
Can we image intracellular calcium with ultrasound? Yes, w/ultrasonic reporters of calcium - URoCs! Congrats to @ZhiyangJin and co-authors on creating the first genetically encoded acoustic biosensors of this universal cell signal based on #gasvesicles. biorxiv.org/content/10.110…
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Mikhail Shapiro (same on bsky)
@mikhailshapiro
May 27, 2023
Can you express multiple genes from a single mRNA at programmable ratios without long intervening sequences or peptide overhangs? 🤔 Yes, with SEMPER! 😉 Congrats @mtduan, @ishaanjdev and coauthors on this new tech for mammalian synbio & gene therapy. biorxiv.org/content/10.110…
58K
Mikhail Shapiro (same on bsky)
@mikhailshapiro
Feb 23, 2023
Can we use ultrasound to remote-control the location and motion of specific cells? Yes! Excited to publish our work on genetically selective acoustic manipulation using #gasvesicles as acoustic actuators. science.org/doi/10.1126/sc… Congrats @di_wu_ and team on this breakthrough!
science.org
Biomolecular actuators for genetically selective acoustic manipulation of cells
Genetically encoded gas-filled nanostructures enable ultrasound to apply force to cells in a selective way.
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Mikhail Shapiro (same on bsky)
@mikhailshapiro
Mar 19, 2019
Congratulations to @farhadi_arash and colleagues in our lab on this feat of synthetic biology, and a leap in non-invasive cellular imaging many years in the making: Ultrasound Imaging of Gene Expression in Mammalian Cells biorxiv.org/content/10.110…
Mikhail Shapiro (same on bsky)
@mikhailshapiro
Oct 4, 2018
Our lab website went down yesterday. Turns out it was an elaborate DDOS attack perpetrated by @francesarnold. Her strategy: host her lab website on the same server in our department, then win the #NobelPrize. (our site is back up now at shapirolab.caltech.edu)