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Patrick Hsu
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Patrick Hsu
@pdhsu
@ArcInstitute co-founder, @Stanford professor, @ThriveCapital investor | biology and ML research | 🇨🇦 prev @harvard @broadinstitute, Fast Grants
patrickhsu.com
Joined March 2009
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  • Pinned
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    Patrick Hsu
    @pdhsu
    Sep 25, 2025
    Today in @ScienceMagazine, we report a new DNA editing technology to seamlessly write massive changes into the right place in the human genome. The reason gene editing hasn't transformed human health is that current gene editing technologies like CRISPR are very limited. The
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    01:32
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    Patrick Hsu
    @pdhsu
    Jun 26, 2024
    What if we could universally recombine, insert, delete, or invert any two pieces of DNA? In back-to-back @Nature papers, we report the discovery of bridge RNAs and 3 atomic structures of the first natural RNA-guided recombinase - a new mechanism for programmable genome design
    694K
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    Patrick Hsu
    @pdhsu
    Jan 16, 2023
    imagine a ChatGPT browser extension that reads the Terms and Conditions agreement and flags anything that is non-standard
    4M
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    Patrick Hsu
    @pdhsu
    Apr 20, 2025
    The tighter my sleep hygiene, the harsher the penalty of a single late night out. Has anyone figured out how to preserve cognitive edge without becoming socially brittle?
    908K
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    Patrick Hsu
    @pdhsu
    Nov 11, 2024
    Terry Tao is the ultimate shape rotator
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    755K
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    Patrick Hsu
    @pdhsu
    Jun 26, 2024
    What if we could universally recombine, insert, delete, or invert any two pieces of DNA? In back-to-back @Nature papers, we report the discovery of bridge RNAs and 3 atomic structures of the first natural RNA-guided recombinase - a new mechanism for programmable genome design
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    00:00
    1.8M
  • user avatar
    Patrick Hsu
    @pdhsu
    Dec 5, 2023
    I was homeschooled until college. To show I was academically prepared in my apps, I took 8 AP exams—the max I could schedule and register for. Went to the bookstore and bought 2 prep books per exam, read all 16 cover to cover over 2 months. That was my American high school
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    Chrisman
    @chrisman
    Dec 5, 2023
    When friends start homeschooling they are invariably shocked at how little time is needed for academics. School just fills the time.
    2.3M
  • user avatar
    Patrick Hsu
    @pdhsu
    Jun 13, 2021
    Assistant Professor Daniel Craig after another week of grant deadlines, re-learning the chi^2 test, and reading 40 abstracts but 0 papers. He loves his job, students, and cold brew coffee.
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    Patrick Hsu
    @pdhsu
    Aug 21, 2025
    Terry Tao almost failed out of his PhD for playing too much Civ. Happens to the best of us…literally 😂
    290K
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    Patrick Hsu
    @pdhsu
    Aug 13, 2023
    scientist after sequencing lots of single cells
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    322K
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    Patrick Hsu
    @pdhsu
    Feb 19, 2025
    AI provides a universal framework that leverages data and compute at scale to uncover higher-order patterns Today, @arcinstitute in collaboration with @nvidia releases Evo 2—a fully open source biological foundation model trained on genomes spanning the entire tree of life 🧵
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    464K
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    Patrick Hsu
    @pdhsu
    Feb 27, 2024
    Is DNA all you need? In new work, we report Evo, a genomic foundation model that learns across the fundamental languages of biology: DNA, RNA, and proteins. Evo is capable of both prediction tasks and generative design, from molecular to whole genome scale.
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    Patrick Hsu
    @pdhsu
    Sep 11, 2023
    Just got my green card and used Global Entry for the first time. 2 sec interaction after the kiosk: “Mr. Hsu, anything to declare? No? Welcome home!” I didn’t realize how much this could mean to me. And what it still feels like to be an immigrant even after so many years here
    301K
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    Patrick Hsu
    @pdhsu
    Jan 25, 2024
    Just shared at @KeystoneSymp a new @arcinstitute discovery of the bridge RNA recombinase mechanism: a new class of natural RNA-guided systems that retains the key property of programmability from RNAi and CRISPR while enabling large-scale genome design beyond RNA and DNA cuts
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    779K
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    Patrick Hsu
    @pdhsu
    Nov 14, 2024
    Today we report Evo, a generalist foundation model for biology, on the cover of @ScienceMagazine. Trained on billions of DNA nucleotides, Evo was designed to capture two key aspects of biology: the multi-modality of the central dogma and the multi-scale nature of evolution.
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    Science Magazine
    @ScienceMagazine
    Nov 14, 2024
    A new Science study presents “Evo”—a machine learning model capable of decoding and designing DNA, RNA, and protein sequences, from molecular to genome scale, with unparalleled accuracy. Evo’s ability to predict, generate, and engineer entire genomic sequences could change the
    308K

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