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Peter Koo
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Peter Koo
@pkoo562
Associate Professor @CSHL | AI x Bio and Healthcare
Cold Spring Harbor, NY
koo-lab.github.io
Joined July 2019
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    Peter Koo
    @pkoo562
    Jun 20
    Excited to share new work on interpreting and steering pathology foundation models! A fun collaboration led by @ChanwooKim_ and @suinleelab, with support from our pathologist collaborators Zhen Zhao and Deepika Savant, and Jakub Kaczmarzyk. Paper: biorxiv.org/content/10.648… 1/N
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    biorxiv.org
    Dissecting and directing pathology foundation models
    Foundation models (FMs) are central to digital pathology, encoding histology images into dense embeddings for facilitating diagnostic classification, molecular alteration prediction, and clinical...
    16K
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    Peter Koo
    @pkoo562
    Dec 5, 2023
    😜
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    30K
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    Peter Koo
    @pkoo562
    Mar 4, 2024
    Do current genomic language models (pre-trained on whole genomes) learn a foundational understanding of biology in the non-coding region of human genomes? A new evaluation led by @AmberZqt suggests not yet! 1/N paper:
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    biorxiv.org
    Evaluating the representational power of pre-trained DNA language models for regulatory genomics
    The emergence of genomic language models (gLMs) offers an unsupervised approach to learning a wide diversity of cis -regulatory patterns in the non-coding genome without requiring labels of functio...
    51K
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    Peter Koo
    @pkoo562
    Dec 5, 2022
    It's currently the wild wild west for deep learning in regulatory genomics. In this @NatMachIntell paper "Evaluating deep learning for predicting epigenomic profiles", we explore the modeling choices that drive robust predictions and interpretable models nature.com/articles/s4225…
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    Peter Koo
    @pkoo562
    Dec 21, 2019
    Interested in #DeepLearning applications in regulatory #genomics? Ever wonder how #NeuralNetwork design choices influence the extent that convolutional filters learn interpretable representations of sequence motifs? Check out our new paper: dx.plos.org/10.1371/journa…
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    Peter Koo
    @pkoo562
    May 2, 2022
    New work led by Shushan Toneyan and Ziqi (Amber) Tang (@AmberZqt) on evaluating deep learning models for predicting epigenomic profiles. #RegulatoryGenomics 1/5 biorxiv.org/content/10.110…
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    Peter Koo
    @pkoo562
    Sep 16, 2024
    Excited that CREME (Cis-Regulatory Element Model Explanations) is published in @NatureGenet! Work led by @ToneyanSh! tl;dr CREME interprets rules of gene regulation learned by genomic deep learning models using carefully designed in silico perturbations. rdcu.be/dT3kq
    16K
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    Peter Koo
    @pkoo562
    May 25, 2024
    Excited to share new work on “Designing DNA With Tunable Regulatory Activity Using Discrete Diffusion.” We extend Score Entropy Discrete Diffusion to regulatory DNA! Work led by @ani_itsme. paper: biorxiv.org/cgi/content/sh…
    30K
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    Peter Koo
    @pkoo562
    Sep 12, 2019
    I am excited to announce that I have started my new lab in the Simons Center for Quantitative Biology at Cold Spring Harbor Laboratory and we have open postdoc positions! For more info: koo-lab.github.io
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    Peter Koo
    @pkoo562
    Mar 21, 2024
    In genomic deep learning, the trends right now are to build bigger models that consider longer sequence contexts. While predictions are more powerful, their scale makes them difficult to interpret. To address this gap, we have developed CREME. Paper: biorxiv.org/content/10.110… 1/N
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    biorxiv.org
    Interpreting Cis-Regulatory Interactions from Large-Scale Deep Neural Networks for Genomics
    The rise of large-scale, sequence-based deep neural networks (DNNs) for predicting gene expression has introduced challenges in their evaluation and interpretation. Current evaluations align DNN...
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    Peter Koo
    @pkoo562
    Jun 15, 2020
    Should we trust #deeplearning predictions in regulatory genomics? Is good test performance enough? Short answer: not necessarily. Check out my lab’s first paper that shows how activation choice in CNNs can play a critical role: biorxiv.org/content/10.110… #FirstLabPaper w/ @MPloenzke
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    biorxiv.org
    Improving representations of genomic sequence motifs in convolutional networks with exponential...
    Deep convolutional neural networks (CNNs) trained on regulatory genomic sequences tend to learn distributed feature representations across many filters, making it challenging to decipher biologically...
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    Peter Koo
    @pkoo562
    Dec 23, 2024
    I'm hiring: 1. PhD-level Research associate to generate perturbation data 2. ML postdoc to build multimodal generative AI for DNA (eg diffusion and LLM) 3. Bioinformatician (any level) to harmonize functional genomics data for training foundation models DM me if interested!
    20K
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    Peter Koo
    @pkoo562
    Nov 17, 2023
    Excited to share new work on "Interpreting cis-regulatory mechanisms from genomic deep neural networks using surrogate models” led by @EESeitz, jointly advised by me and @jbkinney and in collab with @TheDMMcC Paper: biorxiv.org/content/10.110… Docs: squid-nn.readthedocs.io
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  • user avatar
    Peter Koo
    @pkoo562
    Feb 5, 2025
    [SAVE THE DATE] MLCB 2025 is happening Sep 10-11 at the NY Genome Center—NYC! Attend the premier conference at the intersection of ML & Bio, share your research and make lasting connections! Submission deadline: Jun 1 Details: mlcb.github.io Spread the word—please RT!
    13K

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