Engineering rejuvenation.
Ageing may be reversible. We are learning how.
clock.health is building the science and technology to understand, measure and ultimately rejuvenate human cells and tissues.
Engineering rejuvenation.
Ageing may be reversible. We are learning how.
clock.health is building the science and technology to understand, measure and ultimately rejuvenate human cells and tissues.
What if ageing is reversible?
Ageing is usually understood as the progressive accumulation of biological damage.
But damage is only one side of the equation.
Throughout life, cells continuously maintain and repair themselves. We are investigating whether ageing emerges when these repair programmes become insufficient to counteract accumulating damage.
If we can identify the programmes that maintain youthful biological function, understand how they change with age, and learn how to restore them, rejuvenation may become possible.
Our mission is to engineer rejuvenation.
Cells can rejuvenate.
We discovered that human induced pluripotent stem cells can be experimentally aged.
Remarkably, when the ageing pressure is removed, they can return towards a younger biological state.
The observation suggested something fundamental:
Cells retain an intrinsic capacity for rejuvenation.
We wanted to understand how.
Discover.
Finding the biology of rejuvenation.
We systematically perturb genes across the human genome and measure how each perturbation changes cellular age.
Combining genome-scale CRISPR screening with single-cell transcriptomics reveals the genes and biological programmes that regulate cellular ageing and rejuvenation.
GeneAge™ Atlas
A functional map of the biology of rejuvenation.
20,000+ genes interrogated. 151 age-modulating genes identified.
Measure.
Making cellular age measurable.
imAgeScore™ uses machine learning to detect age-associated changes in cellular morphology from microscopy images.
From a single image, we can quantify whether a cellular phenotype is shifting towards an older or younger state.
Rejuvenate.
From genetic discovery to intervention.
GeneAge™ identifies biological targets associated with ageing and rejuvenation.
We then test whether modulating the same targets pharmacologically reproduces the effects predicted by genetic perturbation.
~90% concordance
between genetic perturbation and pharmacological intervention across the targets tested.
Can we rejuvenate human tissue?
Our first focus is human skin.
We will test predicted interventions and measure their effects independently across multiple levels of biology.
A learning system for human rejuvenation.
Every human experiment makes the next prediction better.
Human data connects our molecular predictions to actual rejuvenation.
Each study teaches us which biological signals predict meaningful rejuvenation in humans, improving the interventions we test next.
One biological principle. Many tissues.
The programmes responsible for maintaining and repairing cells operate throughout the body.
By learning how to restore youthful function in human tissue, we aim to build a foundation for applying rejuvenation biology to age-related disease.
Bringing It All Together: Decoding the Rejuvenation Genome for Real-World Impact
We have built a platform unmatched in its ability to model aging in human cells, decode the rejuvenation genome to pinpoint genetic drivers of aging, and rapidly validate what can reverse it. Our geneAge Atlas provides the map of rejuvenation biology, our imAge platform is the compass to navigate and test interventions, and our clinAge platform enables fast in-human iteration.
clock.health’s approach is uniquely fast, functional, and built for translation. By combining deep biology, AI-powered measurement, and real-world validation, we are unlocking the rejuvenation genome and delivering the next generation of healthspan therapeutics.
The challenges
clock.health’s approach
Rejuvenation biology remains largely unknown
We have conducted unbiased CRISPR perturbations to uncover the rejuvenation biology of pluripotent stem cells in less than 12 months
No regulatory framework for rejuvenation/aging interventions
We focus on PoC in skin rejuvenation and nutraceuticals; both have clear regulatory pathways
Novel drugs against new targets pose unknown and potentially severe safety risks
We focus combinations of safe repurposed drugs and supplements
Unknown how many drugs compounds are able to modulate age
Assessing random libraries of approved drugs using our imAge platform indicates that ca -15% drugs are able to modulate age
Unknown whether in vitro findings translates into human clients
Skin rejuvenation is measurable and has a rapid readout; clinAge is designed for rapid iteration
Bringing It All Together: Decoding the Rejuvenation Genome for Real-World Impact
We have built a platform unmatched in its ability to model aging in human cells, decode the rejuvenation genome to pinpoint genetic drivers of aging, and rapidly validate what can reverse it. Our geneAge Atlas provides the map of rejuvenation biology, our imAge platform is the compass to navigate and test interventions, and our clinAge platform enables fast in-human iteration.
clock.health’s approach is uniquely fast, functional, and built for translation. By combining deep biology, AI-powered measurement, and real-world validation, we are unlocking the rejuvenation genome and delivering the next generation of healthspan therapeutics.
