James Olzmann

@OlzmannLab

Professor of Molecular Therapeutics and Metabolic Biology at UC Berkeley; Departments of Molecular & Cell Biology and Nutritional Sciences & Toxicology

Berkeley, California. USA.

olzmannlab.com

Replies Reposts Media

Pinned
James Olzmann
@OlzmannLab
Feb 25
1/ Thrilled to share our new paper in @Nature: “CLCC1 promotes hepatic neutral lipid flux and nuclear pore complex assembly.” From our lab together with @apsarruda, led by co–first authors @alymathiowetz and @EmilyMeymand. 🥳
CLCC1 promotes hepatic neutral lipid flux and nuclear pore complex assembly
From nature.com
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James Olzmann
@OlzmannLab
Sep 3
Excited to see our Preview led by Amalia Megarioti online in Cell, highlighting new work showing that polyamines act as endogenous buffers of labile iron to suppress ferroptosis. Congrats to Pushkal Sharma, Whitney Henry, Ankur Jain and team!👏
Metabolite buffering of labile iron governs ferroptosis
From cell.com
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James Olzmann
@OlzmannLab
Jul 27
Excited to be in Arizona for the FASEB Lipid Droplet and Phospholipid Research Conferences! Looking forward to a great week of science and catching up with colleagues! 🔥
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James Olzmann
@OlzmannLab
Jul 24
A longstanding mystery in Fragile X biology: why does loss of FMRP impair translation of long neurodevelopmental mRNAs? Very cool study identifies a potential mechanism, FMRP protects vulnerable transcripts from inappropriate P-body repression. Exciting disease implications. 🤩
Ethan Greenblatt
@vancityflyguy
Jul 24
I'm incredibly proud of my lab's work defining the mechanism by which fragile X messenger ribonucleoprotein (FMRP) supports translation of long neurodevelopmental mRNAs - a discovery we first made in fruit fly eggs which is conserved in the mammalian brain biorxiv.org/content/10.648…
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James Olzmann
@OlzmannLab
Jul 20
New preprint! We find that fatty acid double-bond geometry alters their metabolic fate and ferroptosis sensitivity. Trans fatty acids are metabolized differently from their cis counterparts, reshaping membrane phospholipids and ferroptosis sensitivity.
biorxiv.org
Double-bond geometry determines fatty acid metabolic fate and ferroptosis sensitivity
Ferroptosis is driven by the accumulation of oxidatively damaged membrane phospholipids, making membrane lipid composition a central determinant of cell death sensitivity. While fatty acid chain...